hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06176
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKDC | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) | UniProt NCBI |
| GCN1 | eIF-2-alpha kinase activator GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1) | UniProt NCBI |
| ECPAS | Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog) | UniProt NCBI |
| XPO1 | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) | UniProt NCBI |
| ARMC6 | Armadillo repeat-containing protein 6 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1183 | 0.00271386118461 | 0.4 | PRKDC GCN1 | CDC5L complex |
| HPA:052010_03 | 0.00980294859364 | 0.8 | PRKDC ECPAS XPO1 ARMC6 | stomach 2; glandular cells[Uncertain,High] |
| HPA:047030_02 | 0.0216345901131 | 0.8 | PRKDC ECPAS XPO1 ARMC6 | soft tissue 1; fibroblasts[Uncertain,Medium] |
| HPA:048010_01 | 0.0446716220879 | 0.8 | PRKDC ECPAS XPO1 ARMC6 | soft tissue 2; adipocytes[Uncertain,Low] |
| WP:WP3302 | 0.0497141369515 | 0.2 | XPO1 | eIF5A regulation in response to inhibition of the nuclear export system |
| CORUM:360 | 0.0499494897235 | 0.2 | PRKDC | Artemis-DNA-PK complex |
| CORUM:361 | 0.0499494897235 | 0.2 | PRKDC | Artemis-DNA-PK complex |
| CORUM:1117 | 0.0499494897235 | 0.2 | XPO1 | CRM1-Survivin mitotic complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GCN1 | XPO1 | 0.482 | 0.613 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| GCN1 | ECPAS | 0.242 | 0.468 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| ECPAS | ARMC6 | 0.059 | 0.333 | bioplex_WMM boldt fraction boldt_WMM |
| GCN1 | PRKDC | 0.059 | 0.328 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM |
| ECPAS | XPO1 | 0.02 | 0.185 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| GCN1 | ARMC6 | 0.013 | 0.143 | hein_WMM bioplex (ARMC6) bioplex_WMM boldt hein (ARMC6) boldt_WMM |
| ARMC6 | PRKDC | 0.006 | 0.008 | bioplex (ARMC6) bioplex_WMM boldt boldt_WMM |
| ECPAS | PRKDC | 0.006 | 0.007 | bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM |
| XPO1 | PRKDC | 0.003 | 0.015 | hein_WMM bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| XPO1 | ARMC6 | 0.0 | 0.01 | hein_WMM bioplex (ARMC6) bioplex_WMM boldt hein (ARMC6) boldt_WMM |
Images
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Complex HuMAP2_06176 has an average edge precision of 0.211 which is ranked 6005 out of all 6965 complexes.
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