hu.MAP 2.0: Complex View

Genename	Protein Name	Links
ICE2	Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2)	UniProt NCBI
APCDD1	Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein)	UniProt NCBI
ELANE	Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase)	UniProt NCBI
MUC5B	Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin)	UniProt NCBI
PCK2	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32)	UniProt NCBI
DMBT1	Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein)	UniProt NCBI
CTSG	Cathepsin G (CG) (EC 3.4.21.20)	UniProt NCBI
MPO	Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0042742	0.0194680313645	0.5	ELANE MPO DMBT1 CTSG	defense response to bacterium
REAC:R-HSA-1592389	0.0206530496387	0.25	ELANE CTSG	Activation of Matrix Metalloproteinases
KEGG:04970	0.0321551626916	0.25	MUC5B DMBT1	Salivary secretion
GO:0019731	0.039179823435	0.375	ELANE DMBT1 CTSG	antibacterial humoral response
CORUM:5388	0.0497224828424	0.125	ELANE	SERPINA1-ELA2 complex
CORUM:5389	0.0497224828424	0.125	CTSG	SERPINA3-CTSG complex
CORUM:5391	0.0497224828424	0.125	CTSG	SERPINA1-CTSG complex
CORUM:6825	0.0497224828424	0.125	MPO	CP-MPO complex

Protein 1	Protein 2	Score	Precision	Evidence
ICE2	MPO	0.844	0.788	bioplex (ICE2) bioplex_WMM
ICE2	CTSG	0.466	0.604	bioplex (ICE2) bioplex_WMM
MUC5B	ICE2	0.409	0.568	bioplex (ICE2) bioplex_WMM
ICE2	ELANE	0.291	0.492	bioplex (ICE2) bioplex_WMM
CTSG	APCDD1	0.033	0.253	bioplex (APCDD1) bioplex_WMM
MPO	APCDD1	0.028	0.23	bioplex (APCDD1) bioplex_WMM
PCK2	DMBT1	0.028	0.232	bioplex (PCK2) bioplex_WMM
PCK2	MUC5B	0.026	0.216	bioplex (PCK2) bioplex_WMM
MUC5B	DMBT1	0.017	0.173	bioplex_WMM WMM_only treiber_WMM
MPO	CTSG	0.01	0.12	bioplex_WMM WMM_only treiber_WMM
DMBT1	MPO	0.009	0.113	bioplex_WMM WMM_only
MUC5B	MPO	0.009	0.108	bioplex_WMM WMM_only
ELANE	CTSG	0.008	0.092	bioplex_WMM WMM_only treiber_WMM
DMBT1	CTSG	0.008	0.084	bioplex_WMM WMM_only
MPO	ELANE	0.008	0.082	bioplex_WMM WMM_only treiber_WMM
DMBT1	ELANE	0.008	0.066	bioplex_WMM WMM_only
MUC5B	CTSG	0.008	0.06	bioplex_WMM WMM_only
MUC5B	ELANE	0.008	0.06	bioplex_WMM WMM_only
PCK2	ICE2	0.007	0.001	youn_WMM WMM_only
DMBT1	ICE2	0.0	0.002	bioplex (ICE2) bioplex_WMM

Click to enlarge

Complex HuMAP2_06200 has an average edge precision of 0.217 which is ranked 5906 out of all 6965 complexes.