hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06208
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | UniProt NCBI |
| CHMP2A | Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1) | UniProt NCBI |
| CHMP2B | Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162588 | 1.47287948045e-06 | 1.0 | CHMP2B CHMP2A VTA1 | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 2.02093811497e-06 | 1.0 | CHMP2B CHMP2A VTA1 | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:1904896 | 1.08982291228e-05 | 1.0 | CHMP2B CHMP2A VTA1 | ESCRT complex disassembly |
| GO:1904903 | 1.08982291228e-05 | 1.0 | CHMP2B CHMP2A VTA1 | ESCRT III complex disassembly |
| KEGG:04144 | 6.09806140287e-05 | 1.0 | CHMP2B CHMP2A VTA1 | Endocytosis |
| CORUM:1186 | 0.000150966163965 | 0.666666666667 | CHMP2B CHMP2A | ESCRT-III complex |
| REAC:R-HSA-162599 | 0.00017233319357 | 1.0 | CHMP2B CHMP2A VTA1 | Late Phase of HIV Life Cycle |
| GO:0046755 | 0.000208882724853 | 1.0 | CHMP2B CHMP2A VTA1 | viral budding |
| REAC:R-HSA-162587 | 0.000228431198544 | 1.0 | CHMP2B CHMP2A VTA1 | HIV Life Cycle |
| GO:0071985 | 0.000265644334868 | 1.0 | CHMP2B CHMP2A VTA1 | multivesicular body sorting pathway |
| GO:0036258 | 0.000368723418654 | 1.0 | CHMP2B CHMP2A VTA1 | multivesicular body assembly |
| GO:0036257 | 0.000408229499224 | 1.0 | CHMP2B CHMP2A VTA1 | multivesicular body organization |
| REAC:R-HSA-162906 | 0.000819826928908 | 1.0 | CHMP2B CHMP2A VTA1 | HIV Infection |
| GO:0019068 | 0.000829990966275 | 1.0 | CHMP2B CHMP2A VTA1 | virion assembly |
| REAC:R-HSA-9615710 | 0.00234745427481 | 0.666666666667 | CHMP2B CHMP2A | Microautophagy |
| REAC:R-HSA-5663205 | 0.00340936351327 | 1.0 | CHMP2B CHMP2A VTA1 | Infectious disease |
| GO:0007032 | 0.00497140885151 | 1.0 | CHMP2B CHMP2A VTA1 | endosome organization |
| KEGG:04217 | 0.00510487583083 | 0.666666666667 | CHMP2B CHMP2A | Necroptosis |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | CHMP2B CHMP2A VTA1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | CHMP2B CHMP2A VTA1 | Vesicle-mediated transport |
| REAC:R-HSA-1632852 | 0.0249521708712 | 0.666666666667 | CHMP2B CHMP2A | Macroautophagy |
| REAC:R-HSA-9612973 | 0.0350118981581 | 0.666666666667 | CHMP2B CHMP2A | Autophagy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CHMP2B | CHMP2A | 0.462 | 0.6 | hein_WMM Guru fraction |
| CHMP2A | VTA1 | 0.041 | 0.268 | hein_WMM bioplex (CHMP2A) bioplex_WMM |
| CHMP2B | VTA1 | 0.007 | 0.001 | hein_WMM WMM_only |
Images
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Complex HuMAP2_06208 has an average edge precision of 0.29 which is ranked 4756 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VTA1 | HuMAP2_00578 HuMAP2_01637 HuMAP2_06208 HuMAP2_06627 HuMAP2_06668 |
| CHMP2A | HuMAP2_00578 HuMAP2_00867 HuMAP2_01274 HuMAP2_06208 HuMAP2_06457 HuMAP2_06627 |
| CHMP2B | HuMAP2_00578 HuMAP2_00867 HuMAP2_01274 HuMAP2_05586 HuMAP2_06208 HuMAP2_06386 HuMAP2_06914 |