hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06216
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PITHD1 | PITH domain-containing protein 1 | UniProt NCBI |
| COLGALT2 | Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2) | UniProt NCBI |
| IK | Protein Red (Cytokine IK) (IK factor) (Protein RER) | UniProt NCBI |
| COLGALT1 | Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (ColGalT 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1) | UniProt NCBI |
| NAMPT | Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin) | UniProt NCBI |
| NLE1 | Notchless protein homolog 1 | UniProt NCBI |
| COL4A2 | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | UniProt NCBI |
| DOK1 | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | UniProt NCBI |
| PLOD3 | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 6.7258150276e-06 | 0.444444444444 | PLOD3 COLGALT1 COL4A2 COLGALT2 | Collagen biosynthesis and modifying enzymes |
| KEGG:00514 | 1.03287475701e-05 | 0.333333333333 | PLOD3 COLGALT2 COLGALT1 | Other types of O-glycan biosynthesis |
| REAC:R-HSA-1474290 | 2.31260502751e-05 | 0.444444444444 | PLOD3 COLGALT1 COL4A2 COLGALT2 | Collagen formation |
| GO:0050211 | 3.05058200216e-05 | 0.333333333333 | PLOD3 COLGALT2 COLGALT1 | procollagen galactosyltransferase activity |
| CORUM:6997 | 4.02261743042e-05 | 0.222222222222 | PLOD3 COLGALT1 | ADIPOQ-PLOD3-GLT25D1 complex |
| KEGG:00310 | 0.000276134574071 | 0.333333333333 | PLOD3 COLGALT2 COLGALT1 | Lysine degradation |
| GO:0035250 | 0.00217524004777 | 0.333333333333 | PLOD3 COLGALT2 COLGALT1 | UDP-galactosyltransferase activity |
| REAC:R-HSA-1474244 | 0.00236140534909 | 0.444444444444 | PLOD3 COLGALT1 COL4A2 COLGALT2 | Extracellular matrix organization |
| GO:0008378 | 0.00735659813211 | 0.333333333333 | PLOD3 COLGALT2 COLGALT1 | galactosyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLOD3 | COLGALT1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COLGALT2 | DOK1 | 0.109 | 0.373 | bioplex (COLGALT2) bioplex_WMM |
| COLGALT2 | COLGALT1 | 0.103 | 0.366 | bioplex (COLGALT2) bioplex_WMM |
| COLGALT2 | PLOD3 | 0.098 | 0.358 | bioplex (COLGALT2) bioplex_WMM |
| COL4A2 | COLGALT2 | 0.047 | 0.291 | bioplex (COLGALT2) bioplex_WMM |
| IK | COLGALT1 | 0.029 | 0.23 | bioplex_WMM youn_WMM fraction treiber_WMM |
| PITHD1 | IK | 0.027 | 0.224 | youn_WMM fraction |
| COLGALT1 | NLE1 | 0.022 | 0.208 | fraction |
| PLOD3 | NLE1 | 0.021 | 0.195 | fraction |
| NAMPT | NLE1 | 0.02 | 0.185 | fraction treiber_WMM |
| COL4A2 | COLGALT1 | 0.013 | 0.149 | bioplex_WMM WMM_only boldt_WMM |
| COL4A2 | PLOD3 | 0.012 | 0.149 | bioplex_WMM WMM_only boldt_WMM |
| COL4A2 | DOK1 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| IK | NAMPT | 0.007 | 0.006 | gupta_WMM WMM_only treiber_WMM |
| DOK1 | COLGALT1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| DOK1 | PLOD3 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| IK | NLE1 | 0.007 | 0.0 | youn_WMM WMM_only |
| COLGALT2 | NAMPT | 0.007 | 0.0 | bioplex_WMM WMM_only |
| IK | PLOD3 | 0.007 | 0.0 | gupta_WMM WMM_only treiber_WMM |
| PITHD1 | NAMPT | 0.007 | 0.003 | WMM_only |
| COL4A2 | NAMPT | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PLOD3 | NAMPT | 0.006 | 0.008 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| COLGALT1 | NAMPT | 0.005 | 0.009 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_06216 has an average edge precision of 0.162 which is ranked 6602 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PITHD1 | HuMAP2_00789 HuMAP2_01282 HuMAP2_05921 HuMAP2_06216 |
| COLGALT2 | HuMAP2_02722 HuMAP2_06216 HuMAP2_06790 |
| IK | HuMAP2_00789 HuMAP2_01282 HuMAP2_01328 HuMAP2_01654 HuMAP2_04631 HuMAP2_06216 HuMAP2_06619 |
| COLGALT1 | HuMAP2_02722 HuMAP2_06216 |
| NAMPT | HuMAP2_06079 HuMAP2_06216 |
| NLE1 | HuMAP2_06216 |
| COL4A2 | HuMAP2_02722 HuMAP2_04238 HuMAP2_05080 HuMAP2_06216 HuMAP2_06790 |
| DOK1 | HuMAP2_02722 HuMAP2_04106 HuMAP2_06216 HuMAP2_06790 |
| PLOD3 | HuMAP2_02722 HuMAP2_06216 |