hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06218

Confidence: Medium

Genename	Protein Name	Links
PNISR	Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)	UniProt NCBI
BOD1L1	Biorientation of chromosomes in cell division protein 1-like 1	UniProt NCBI
KIFC1	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET)	UniProt NCBI
NUP50	Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50)	UniProt NCBI
KPNA1	Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed]	UniProt NCBI
RNGTT	mRNA-capping enzyme (HCAP1) (HCE) [Includes: Polynucleotide 5'-triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]	UniProt NCBI
KPNA6	Importin subunit alpha-7 (Karyopherin subunit alpha-6)	UniProt NCBI
RNMT	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p)	UniProt NCBI
KPNA5	Importin subunit alpha-6 (Karyopherin subunit alpha-5)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5663205	0.000180924056233	0.555555555556	KPNA5 RNGTT KPNA1 RNMT NUP50	Infectious disease
REAC:R-HSA-162587	0.000214088994436	0.444444444444	NUP50 KPNA1 RNMT RNGTT	HIV Life Cycle
REAC:R-HSA-168276	0.000233741537372	0.333333333333	KPNA5 KPNA1 NUP50	NS1 Mediated Effects on Host Pathways
REAC:R-HSA-168253	0.000253699748551	0.333333333333	KPNA5 KPNA1 NUP50	Host Interactions with Influenza Factors
REAC:R-HSA-162906	0.00115768487299	0.444444444444	NUP50 KPNA1 RNMT RNGTT	HIV Infection
REAC:R-HSA-1169408	0.00142807644904	0.333333333333	KPNA5 KPNA1 NUP50	ISG15 antiviral mechanism
REAC:R-HSA-1169410	0.00192834856978	0.333333333333	KPNA5 KPNA1 NUP50	Antiviral mechanism by IFN-stimulated genes
KEGG:05164	0.00395604421584	0.333333333333	KPNA5 KPNA1 KPNA6	Influenza A
GO:0005643	0.00407883187879	0.444444444444	KPNA5 KPNA1 KPNA6 NUP50	nuclear pore
GO:0006607	0.00865220447533	0.333333333333	KPNA5 KPNA1 KPNA6	NLS-bearing protein import into nucleus
REAC:R-HSA-162599	0.0112001776415	0.333333333333	NUP50 RNGTT RNMT	Late Phase of HIV Life Cycle
GO:0006606	0.0112788830478	0.444444444444	KPNA5 KPNA1 KPNA6 NUP50	protein import into nucleus
GO:0008139	0.0116809984418	0.333333333333	KPNA5 KPNA1 KPNA6	nuclear localization sequence binding
REAC:R-HSA-168254	0.0153986262903	0.333333333333	KPNA5 KPNA1 NUP50	Influenza Infection
REAC:R-HSA-1643685	0.0210172589272	0.555555555556	KPNA5 RNGTT KPNA1 RNMT NUP50	Disease
REAC:R-HSA-77075	0.0225184776205	0.222222222222	RNGTT RNMT	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-167160	0.0225184776205	0.222222222222	RNGTT RNMT	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
MIRNA:hsa-miR-103a-3p	0.0226275958546	0.444444444444	NUP50 KPNA1 RNMT PNISR	hsa-miR-103a-3p
GO:0051170	0.0236641038012	0.444444444444	KPNA5 KPNA1 KPNA6 NUP50	import into nucleus
REAC:R-HSA-168271	0.0242430667307	0.222222222222	NUP50 KPNA1	Transport of Ribonucleoproteins into the Host Nucleus
REAC:R-HSA-913531	0.0249025058218	0.333333333333	KPNA5 KPNA1 NUP50	Interferon Signaling
REAC:R-HSA-72086	0.0260306873727	0.222222222222	RNGTT RNMT	mRNA Capping
REAC:R-HSA-180910	0.0278812797455	0.222222222222	NUP50 KPNA1	Vpr-mediated nuclear import of PICs
REAC:R-HSA-176033	0.0338102897868	0.222222222222	NUP50 KPNA1	Interactions of Vpr with host cellular proteins
GO:0017038	0.0494507017216	0.444444444444	KPNA5 KPNA1 KPNA6 NUP50	protein import

Edges

Protein 1	Protein 2	Score	Precision	Evidence
NUP50	KIFC1	1.0	0.949	hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KIFC1) gupta_WMM
NUP50	RNGTT	0.986	0.901	youn (RNGTT) bioplex (NUP50,RNGTT) bioplex_WMM boldt youn_WMM boldt_WMM
KPNA1	NUP50	0.894	0.82	hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM hein (KPNA1) gupta_WMM treiber_WMM
NUP50	BOD1L1	0.886	0.817	bioplex (NUP50) bioplex_WMM youn_WMM
NUP50	KPNA5	0.118	0.391	bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM
KPNA6	NUP50	0.111	0.381	hein_WMM bioplex (NUP50) bioplex_WMM youn_WMM gupta_WMM
KPNA1	RNMT	0.06	0.335	hein_WMM bioplex (RNMT) bioplex_WMM youn_WMM hein (KPNA1)
KPNA6	KPNA1	0.05	0.296	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
KPNA6	RNMT	0.033	0.252	bioplex (RNMT) bioplex_WMM youn_WMM
KIFC1	PNISR	0.031	0.238	hein_WMM youn_WMM hein (KIFC1) gupta_WMM
KPNA5	RNMT	0.023	0.21	bioplex (RNMT) bioplex_WMM youn_WMM
KPNA6	KPNA5	0.012	0.146	bioplex_WMM youn_WMM gupta_WMM WMM_only
KPNA1	KPNA5	0.012	0.144	bioplex_WMM youn_WMM gupta_WMM WMM_only
NUP50	RNMT	0.009	0.106	hein_WMM bioplex (NUP50,RNMT) bioplex_WMM youn_WMM
KIFC1	BOD1L1	0.009	0.102	bioplex_WMM youn_WMM WMM_only
RNGTT	BOD1L1	0.009	0.091	youn (RNGTT) bioplex_WMM youn_WMM boldt_WMM
KPNA6	RNGTT	0.008	0.083	youn (RNGTT) bioplex_WMM youn_WMM
KPNA1	KIFC1	0.008	0.065	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
RNGTT	RNMT	0.008	0.06	youn (RNGTT) bioplex_WMM youn_WMM
KIFC1	KPNA5	0.008	0.027	bioplex_WMM youn_WMM WMM_only
KIFC1	RNMT	0.008	0.024	bioplex_WMM youn_WMM WMM_only
RNGTT	PNISR	0.008	0.011	youn (RNGTT) youn_WMM
KPNA1	RNGTT	0.007	0.007	bioplex_WMM youn_WMM WMM_only
KPNA1	PNISR	0.007	0.006	youn_WMM gupta_WMM WMM_only
KPNA6	BOD1L1	0.007	0.007	bioplex_WMM youn_WMM WMM_only
BOD1L1	KPNA5	0.007	0.004	bioplex_WMM youn_WMM WMM_only
KPNA1	BOD1L1	0.007	0.007	bioplex_WMM youn_WMM WMM_only
KPNA6	KIFC1	0.007	0.01	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
PNISR	RNMT	0.007	0.009	youn_WMM WMM_only
BOD1L1	PNISR	0.007	0.012	youn_WMM WMM_only
KPNA6	PNISR	0.007	0.01	youn_WMM gupta_WMM WMM_only
BOD1L1	RNMT	0.007	0.005	bioplex_WMM youn_WMM WMM_only
PNISR	KPNA5	0.007	0.005	youn_WMM gupta_WMM WMM_only
NUP50	PNISR	0.007	0.008	hein_WMM youn_WMM gupta_WMM WMM_only
RNGTT	KPNA5	0.006	0.004	youn (RNGTT) bioplex_WMM youn_WMM
RNGTT	KIFC1	0.003	0.007	youn (RNGTT) bioplex_WMM youn_WMM fraction

Images

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Complex HuMAP2_06218 has an average edge precision of 0.182 which is ranked 6411 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PNISR	HuMAP2_02924 HuMAP2_06218 HuMAP2_06806
BOD1L1	HuMAP2_02172 HuMAP2_03130 HuMAP2_03873 HuMAP2_06127 HuMAP2_06218 HuMAP2_06953
KIFC1	HuMAP2_01473 HuMAP2_03236 HuMAP2_04098 HuMAP2_06117 HuMAP2_06218 HuMAP2_06750 HuMAP2_06806
NUP50	HuMAP2_01285 HuMAP2_01473 HuMAP2_03236 HuMAP2_04098 HuMAP2_05429 HuMAP2_06117 HuMAP2_06218
KPNA1	HuMAP2_01285 HuMAP2_01473 HuMAP2_04098 HuMAP2_04630 HuMAP2_05768 HuMAP2_06117 HuMAP2_06137 HuMAP2_06218
RNGTT	HuMAP2_01473 HuMAP2_03236 HuMAP2_04098 HuMAP2_05762 HuMAP2_06117 HuMAP2_06218
KPNA6	HuMAP2_00200 HuMAP2_01285 HuMAP2_02561 HuMAP2_04098 HuMAP2_04630 HuMAP2_06137 HuMAP2_06218
RNMT	HuMAP2_04098 HuMAP2_04630 HuMAP2_05584 HuMAP2_05768 HuMAP2_06137 HuMAP2_06218
KPNA5	HuMAP2_03236 HuMAP2_04098 HuMAP2_04630 HuMAP2_06137 HuMAP2_06218

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06218