hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06224

Confidence: Medium High

Genename	Protein Name	Links
PCLAF	PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)	UniProt NCBI
FEN1	Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)	UniProt NCBI
UGT3A1	UDP-glucuronosyltransferase 3A1 (UDPGT 3A1) (EC 2.4.1.17)	UniProt NCBI
PCNA	Proliferating cell nuclear antigen (PCNA) (Cyclin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1039	5.02777038712e-06	0.5	PCLAF PCNA	PCNA-PAF complex
REAC:R-HSA-174437	0.000452175281072	0.5	PCNA FEN1	Removal of the Flap Intermediate from the C-strand
REAC:R-HSA-174414	0.000552609179875	0.5	PCNA FEN1	Processive synthesis on the C-strand of the telomere
REAC:R-HSA-69166	0.000914071346391	0.5	PCNA FEN1	Removal of the Flap Intermediate
KEGG:03410	0.000991147720711	0.5	PCNA FEN1	Base excision repair
REAC:R-HSA-69183	0.00105460323216	0.5	PCNA FEN1	Processive synthesis on the lagging strand
KEGG:03030	0.00125846611038	0.5	PCNA FEN1	DNA replication
REAC:R-HSA-69186	0.0019074750117	0.5	PCNA FEN1	Lagging Strand Synthesis
REAC:R-HSA-5651801	0.00210807296175	0.5	PCNA FEN1	PCNA-Dependent Long Patch Base Excision Repair
REAC:R-HSA-174417	0.00276986547413	0.5	PCNA FEN1	Telomere C-strand (Lagging Strand) Synthesis
REAC:R-HSA-110373	0.00301045354831	0.5	PCNA FEN1	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REAC:R-HSA-180786	0.00436320194063	0.5	PCNA FEN1	Extension of Telomeres
REAC:R-HSA-5656169	0.00466369436644	0.5	PCLAF PCNA	Termination of translesion DNA synthesis
REAC:R-HSA-69190	0.00497416142364	0.5	PCNA FEN1	DNA strand elongation
WP:WP4016	0.00501103584449	0.5	PCNA FEN1	DNA IR-damage and cellular response via ATR
REAC:R-HSA-73933	0.00596538345738	0.5	PCNA FEN1	Resolution of Abasic Sites (AP sites)
REAC:R-HSA-110313	0.0070462802506	0.5	PCLAF PCNA	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
REAC:R-HSA-73894	0.00725712676591	0.75	PCLAF PCNA FEN1	DNA Repair
REAC:R-HSA-73893	0.0108262926188	0.5	PCLAF PCNA	DNA Damage Bypass
CORUM:2231	0.0249595281251	0.25	PCNA	PCNA homotrimer complex
MIRNA:hsa-miR-3156-5p	0.0281535250235	0.5	PCLAF UGT3A1	hsa-miR-3156-5p
REAC:R-HSA-157579	0.0323499619092	0.5	PCNA FEN1	Telomere Maintenance
REAC:R-HSA-73884	0.0373320991746	0.5	PCNA FEN1	Base Excision Repair
CORUM:7282	0.0499140284799	0.25	FEN1	FEN1-WRN complex
CORUM:314	0.0499140284799	0.25	PCNA	PCNA-p21 complex
CORUM:1040	0.0499140284799	0.25	PCLAF	p33ING1b-PCNA complex
CORUM:1163	0.0499140284799	0.25	PCNA	ING1-PCNA complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PCLAF	PCNA	0.997	0.933	hein_WMM bioplex (PCNA) bioplex_WMM hein (PCNA)
FEN1	PCNA	0.984	0.899	hein_WMM bioplex (FEN1) bioplex_WMM youn_WMM hein (FEN1,PCNA) gupta_WMM boldt_WMM treiber_WMM
UGT3A1	PCNA	0.049	0.295	bioplex (UGT3A1) fraction
FEN1	PCLAF	0.008	0.012	hein_WMM WMM_only

Images

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Complex HuMAP2_06224 has an average edge precision of 0.535 which is ranked 2306 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PCLAF	HuMAP2_00775 HuMAP2_04364 HuMAP2_05422 HuMAP2_05853 HuMAP2_06224
FEN1	HuMAP2_00386 HuMAP2_01543 HuMAP2_05422 HuMAP2_06224 HuMAP2_06766
UGT3A1	HuMAP2_00775 HuMAP2_02165 HuMAP2_06224
PCNA	HuMAP2_00775 HuMAP2_05422 HuMAP2_06224

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06224