hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06225
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NCKAP1 | Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) | UniProt NCBI |
| WASF1 | Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1) | UniProt NCBI |
| ABI1 | Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1) | UniProt NCBI |
| WASF2 | Wiskott-Aldrich syndrome protein family member 2 (WASP family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031209 | 1.70768929464e-09 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | SCAR complex |
| REAC:R-HSA-5663213 | 4.74851893082e-09 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | RHO GTPases Activate WASPs and WAVEs |
| CORUM:186 | 6.75163031135e-09 | 0.75 | NCKAP1 ABI1 WASF2 | Wave-2 complex |
| REAC:R-HSA-2029482 | 4.12752946315e-08 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 1.43433204175e-07 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-4420097 | 2.42383958954e-07 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 3.41390578662e-07 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Signaling by VEGF |
| KEGG:05130 | 7.1423156032e-07 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Pathogenic Escherichia coli infection |
| CORUM:2294 | 5.02777038712e-06 | 0.5 | ABI1 WASF2 | ABI1-WASF2 complex |
| REAC:R-HSA-195258 | 3.37844063501e-05 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | RHO GTPase Effectors |
| WP:WP51 | 8.39876098155e-05 | 0.75 | NCKAP1 WASF2 WASF1 | Regulation of Actin Cytoskeleton |
| REAC:R-HSA-9006934 | 0.00010216546718 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-194315 | 0.000127392742142 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Signaling by Rho GTPases |
| KEGG:04810 | 0.000285912023079 | 0.75 | NCKAP1 WASF2 WASF1 | Regulation of actin cytoskeleton |
| REAC:R-HSA-168249 | 0.00243001134371 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Innate Immune System |
| KEGG:05131 | 0.00401698930658 | 0.5 | WASF1 WASF2 | Shigellosis |
| KEGG:05132 | 0.00440435122993 | 0.5 | WASF1 WASF2 | Salmonella infection |
| KEGG:04520 | 0.00467243468204 | 0.5 | WASF1 WASF2 | Adherens junction |
| KEGG:05100 | 0.00523220354961 | 0.5 | WASF1 WASF2 | Bacterial invasion of epithelial cells |
| GO:0007015 | 0.00694444966719 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | actin filament organization |
| KEGG:04666 | 0.00761107721317 | 0.5 | WASF1 WASF2 | Fc gamma R-mediated phagocytosis |
| KEGG:05231 | 0.00778534503861 | 0.5 | WASF1 WASF2 | Choline metabolism in cancer |
| GO:0038094 | 0.0244411426287 | 0.75 | NCKAP1 ABI1 WASF2 | Fc-gamma receptor signaling pathway |
| GO:0002433 | 0.0244411426287 | 0.75 | NCKAP1 ABI1 WASF2 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0048010 | 0.0244411426287 | 0.75 | NCKAP1 ABI1 WASF2 | vascular endothelial growth factor receptor signaling pathway |
| GO:0038096 | 0.0244411426287 | 0.75 | NCKAP1 ABI1 WASF2 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0002431 | 0.0264744736345 | 0.75 | NCKAP1 ABI1 WASF2 | Fc receptor mediated stimulatory signaling pathway |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | NCKAP1 WASF1 ABI1 WASF2 | Immune System |
| GO:2000601 | 0.0405595771497 | 0.5 | NCKAP1 WASF1 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| CORUM:7561 | 0.0499140284799 | 0.25 | NCKAP1 | NCKAP1-WASF3 complex |
| CORUM:2297 | 0.0499140284799 | 0.25 | ABI1 | ABI1-WASL complex |
| CORUM:6504 | 0.0499140284799 | 0.25 | ABI1 | SOS1-ABI1-EPS8L3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ABI1 | NCKAP1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (ABI1) Malo gupta_WMM fraction boldt_WMM |
| ABI1 | WASF1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (ABI1) Malo fraction boldt_WMM |
| WASF2 | ABI1 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (ABI1) Malo gupta_WMM fraction boldt_WMM |
| WASF1 | NCKAP1 | 0.997 | 0.929 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| WASF2 | NCKAP1 | 0.987 | 0.902 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM |
| WASF2 | WASF1 | 0.02 | 0.188 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
Images
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Complex HuMAP2_06225 has an average edge precision of 0.811 which is ranked 910 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NCKAP1 | HuMAP2_00378 HuMAP2_03322 HuMAP2_06225 HuMAP2_06838 |
| WASF1 | HuMAP2_00378 HuMAP2_06225 HuMAP2_06838 |
| ABI1 | HuMAP2_00378 HuMAP2_03322 HuMAP2_06225 HuMAP2_06838 |
| WASF2 | HuMAP2_00378 HuMAP2_06225 HuMAP2_06838 |