hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06244
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CUL9 | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | UniProt NCBI |
| TP53 | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | UniProt NCBI |
| CUL7 | Cullin-7 (CUL-7) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6577 | 7.88746938166e-09 | 1.0 | TP53 CUL9 CUL7 | 3M complex |
| WP:WP4284 | 0.0142843877495 | 0.333333333333 | TP53 | Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer |
| CORUM:2681 | 0.0249904952816 | 0.333333333333 | TP53 | p53 homotetramer complex |
| WP:WP4399 | 0.0285649389616 | 0.333333333333 | TP53 | MicroRNA network associated with chronic lymphocytic leukemia |
| WP:WP3672 | 0.0357037760272 | 0.333333333333 | TP53 | LncRNA-mediated mechanisms of therapeutic resistance |
| WP:WP2249 | 0.0428416541517 | 0.333333333333 | TP53 | Metastatic brain tumor |
| WP:WP4191 | 0.0428416541517 | 0.333333333333 | TP53 | Caloric restriction and aging |
| CORUM:2678 | 0.0499776345577 | 0.333333333333 | TP53 | FOXO3-TP53 complex, oxidative stress stimulated |
| CORUM:2679 | 0.0499776345577 | 0.333333333333 | TP53 | p53-SP1 complex |
| CORUM:2821 | 0.0499776345577 | 0.333333333333 | TP53 | hSIR2-p53 complex |
| CORUM:5811 | 0.0499776345577 | 0.333333333333 | TP53 | p53-BCL2 complex |
| CORUM:5812 | 0.0499776345577 | 0.333333333333 | TP53 | p53-BCL2 complex |
| CORUM:7180 | 0.0499776345577 | 0.333333333333 | TP53 | p53-MDM2 complex |
| CORUM:7420 | 0.0499776345577 | 0.333333333333 | TP53 | TP53-TSPY1-USP7 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TP53 | CUL9 | 0.996 | 0.925 | bioplex (TP53) bioplex_WMM |
| TP53 | CUL7 | 0.088 | 0.353 | bioplex (TP53) bioplex_WMM |
| CUL9 | CUL7 | 0.009 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06244 has an average edge precision of 0.456 which is ranked 2826 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CUL9 | HuMAP2_00320 HuMAP2_06244 |
| TP53 | HuMAP2_00320 HuMAP2_06244 |
| CUL7 | HuMAP2_06244 HuMAP2_06872 |