hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06245
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TNRC6A | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 3.51943927099e-05 | 1.0 | TNRC6A AGO3 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 4.69258569465e-05 | 1.0 | TNRC6A AGO3 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-8943723 | 6.03332446455e-05 | 1.0 | TNRC6A AGO3 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-8934593 | 0.000227925590883 | 1.0 | TNRC6A AGO3 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9022692 | 0.000680424925724 | 1.0 | TNRC6A AGO3 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-2559585 | 0.000831258037338 | 1.0 | TNRC6A AGO3 | Oncogene Induced Senescence |
| REAC:R-HSA-4086398 | 0.00230942253115 | 1.0 | TNRC6A AGO3 | Ca2+ pathway |
| REAC:R-HSA-8986944 | 0.00230942253115 | 1.0 | TNRC6A AGO3 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-5628897 | 0.0052959181411 | 1.0 | TNRC6A AGO3 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-5687128 | 0.00626962967274 | 1.0 | TNRC6A AGO3 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912408 | 0.00686290657842 | 1.0 | TNRC6A AGO3 | Pre-NOTCH Transcription and Translation |
| MIRNA:hsa-miR-4528 | 0.00694159421376 | 1.0 | TNRC6A AGO3 | hsa-miR-4528 |
| REAC:R-HSA-8936459 | 0.0070154156135 | 1.0 | TNRC6A AGO3 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| MIRNA:hsa-miR-382-3p | 0.00713713207894 | 1.0 | TNRC6A AGO3 | hsa-miR-382-3p |
| REAC:R-HSA-1912422 | 0.00950416195513 | 1.0 | TNRC6A AGO3 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-2559580 | 0.0123699910758 | 1.0 | TNRC6A AGO3 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-211000 | 0.0144900342557 | 1.0 | TNRC6A AGO3 | Gene Silencing by RNA |
| REAC:R-HSA-6807070 | 0.0151587277172 | 1.0 | TNRC6A AGO3 | PTEN Regulation |
| MIRNA:hsa-miR-4795-3p | 0.0154013226863 | 1.0 | TNRC6A AGO3 | hsa-miR-4795-3p |
| REAC:R-HSA-3858494 | 0.0156129029755 | 1.0 | TNRC6A AGO3 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-9018519 | 0.0165413645736 | 1.0 | TNRC6A AGO3 | Estrogen-dependent gene expression |
| MIRNA:hsa-miR-6878-3p | 0.0242005266193 | 1.0 | TNRC6A AGO3 | hsa-miR-6878-3p |
| MIRNA:hsa-miR-152-3p | 0.0291432893223 | 1.0 | TNRC6A AGO3 | hsa-miR-152-3p |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | TNRC6A AGO3 | Cellular Senescence |
| MIRNA:hsa-miR-652-3p | 0.0311665630662 | 1.0 | TNRC6A AGO3 | hsa-miR-652-3p |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | TNRC6A AGO3 | ESR-mediated signaling |
| GO:0045974 | 0.0351642260875 | 1.0 | TNRC6A AGO3 | regulation of translation, ncRNA-mediated |
| GO:0040033 | 0.0351642260875 | 1.0 | TNRC6A AGO3 | negative regulation of translation, ncRNA-mediated |
| GO:0035278 | 0.0351642260875 | 1.0 | TNRC6A AGO3 | miRNA mediated inhibition of translation |
| GO:0031332 | 0.0351642260875 | 1.0 | TNRC6A AGO3 | RNAi effector complex |
| GO:0016442 | 0.0351642260875 | 1.0 | TNRC6A AGO3 | RISC complex |
| REAC:R-HSA-8878171 | 0.0400059689703 | 1.0 | TNRC6A AGO3 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 0.0403729962086 | 1.0 | TNRC6A AGO3 | Signaling by NOTCH |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | TNRC6A AGO3 | PIP3 activates AKT signaling |
| REAC:R-HSA-5683057 | 0.0464733576116 | 1.0 | TNRC6A AGO3 | MAPK family signaling cascades |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | TNRC6A AGO3 | Signaling by Nuclear Receptors |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TNRC6A | AGO3 | 0.665 | 0.7 | hein_WMM youn (TNRC6A) bioplex_WMM youn_WMM hein (AGO3) |
Images
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Complex HuMAP2_06245 has an average edge precision of 0.7 which is ranked 1371 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TNRC6A | HuMAP2_00153 HuMAP2_00478 HuMAP2_01955 HuMAP2_06245 |
| AGO3 | HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_01955 HuMAP2_04784 HuMAP2_06154 HuMAP2_06245 |