hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06246
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DAZL | Deleted in azoospermia-like (DAZ homolog) (DAZ-like autosomal) (Deleted in azoospermia-like 1) (SPGY-like-autosomal) | UniProt NCBI |
| TOP3B | DNA topoisomerase 3-beta-1 (EC 5.6.2.2) (DNA topoisomerase III beta-1) | UniProt NCBI |
| FXR2 | Fragile X mental retardation syndrome-related protein 2 | UniProt NCBI |
| FMR1 | Synaptic functional regulator FMR1 (Fragile X mental retardation protein 1) (FMRP) (Protein FMR-1) | UniProt NCBI |
| FXR1 | Fragile X mental retardation syndrome-related protein 1 (hFXR1p) | UniProt NCBI |
| TDRD3 | Tudor domain-containing protein 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044326 | 1.81637152046e-06 | 0.5 | FXR1 FMR1 FXR2 | dendritic spine neck |
| GO:1902737 | 7.26438828159e-06 | 0.5 | FXR1 FMR1 FXR2 | dendritic filopodium |
| CORUM:7407 | 8.39001385941e-06 | 0.333333333333 | TDRD3 TOP3B | TOP3B-c complex |
| GO:0003730 | 0.000417891539136 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | mRNA 3'-UTR binding |
| KEGG:03013 | 0.0009622006058 | 0.5 | FXR1 FMR1 FXR2 | RNA transport |
| GO:0045727 | 0.000968898210955 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | positive regulation of translation |
| GO:0045182 | 0.00208860909913 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | translation regulator activity |
| GO:0034250 | 0.0024130539346 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | positive regulation of cellular amide metabolic process |
| GO:0043488 | 0.00922585660771 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | regulation of mRNA stability |
| GO:0043487 | 0.0101950303288 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | regulation of RNA stability |
| GO:0051489 | 0.0140408309691 | 0.5 | FXR1 FMR1 FXR2 | regulation of filopodium assembly |
| GO:0061013 | 0.0145203790873 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | regulation of mRNA catabolic process |
| GO:0033592 | 0.020283420769 | 0.333333333333 | FXR1 FMR1 | RNA strand annealing activity |
| GO:0003729 | 0.0321337430886 | 0.666666666667 | FXR1 FXR2 FMR1 DAZL | mRNA binding |
| GO:0046847 | 0.0332327932613 | 0.5 | FXR1 FMR1 FXR2 | filopodium assembly |
| GO:0003723 | 0.0386338629612 | 1.0 | FMR1 TDRD3 FXR2 TOP3B DAZL FXR1 | RNA binding |
| CORUM:5360 | 0.0499726005494 | 0.166666666667 | FXR1 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FMR1 | FXR1 | 0.976 | 0.888 | hein_WMM youn (FMR1,FXR1) bioplex (FMR1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FMR1 | FXR2 | 0.778 | 0.752 | hein_WMM youn (FMR1,FXR2) bioplex (FMR1,FXR2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FXR2 | FXR1 | 0.281 | 0.487 | hein_WMM youn (FXR1,FXR2) bioplex (FXR2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| FMR1 | TOP3B | 0.161 | 0.418 | hein_WMM youn (FMR1,TOP3B) youn_WMM treiber_WMM |
| TDRD3 | FMR1 | 0.058 | 0.325 | hein_WMM youn (FMR1,TDRD3) youn_WMM gupta_WMM fraction |
| TOP3B | FXR2 | 0.029 | 0.23 | hein_WMM youn (FXR2,TOP3B) youn_WMM gupta_WMM treiber_WMM |
| DAZL | TOP3B | 0.025 | 0.21 | youn (DAZL) |
| TDRD3 | FXR1 | 0.021 | 0.194 | hein_WMM youn (FXR1,TDRD3) youn_WMM gupta_WMM |
| TDRD3 | FXR2 | 0.009 | 0.097 | youn (FXR2,TDRD3) youn_WMM gupta_WMM |
| TDRD3 | DAZL | 0.008 | 0.083 | youn (DAZL) |
| TDRD3 | TOP3B | 0.005 | 0.007 | hein_WMM youn (TDRD3,TOP3B) Guru youn_WMM gupta_WMM fraction |
| DAZL | FXR1 | 0.005 | 0.011 | youn (DAZL) |
| FMR1 | DAZL | 0.005 | 0.012 | youn (DAZL) |
| DAZL | FXR2 | 0.005 | 0.007 | youn (DAZL) |
| TOP3B | FXR1 | 0.0 | 0.014 | hein_WMM youn (FXR1,TOP3B) youn_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_06246 has an average edge precision of 0.249 which is ranked 5390 out of all 6965 complexes.
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