hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06250
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | UniProt NCBI |
| GSPT1 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog) | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0002184 | 9.08185760231e-08 | 1.0 | GSPT1 ETF1 GSPT2 | cytoplasmic translational termination |
| GO:0018444 | 9.08185760231e-08 | 1.0 | GSPT1 ETF1 GSPT2 | translation release factor complex |
| GO:0003747 | 1.81637152046e-06 | 1.0 | GSPT1 ETF1 GSPT2 | translation release factor activity |
| GO:0008079 | 1.81637152046e-06 | 1.0 | GSPT1 ETF1 GSPT2 | translation termination factor activity |
| KEGG:03015 | 3.30002227102e-06 | 1.0 | GSPT1 ETF1 GSPT2 | mRNA surveillance pathway |
| CORUM:809 | 3.35600554376e-06 | 0.666666666667 | GSPT1 ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
| CORUM:784 | 2.01342304124e-05 | 0.666666666667 | GSPT1 ETF1 | SMG-1-UPF-ERF1-ERF3 complex (SURF) |
| REAC:R-HSA-72764 | 5.64603800841e-05 | 1.0 | GSPT1 ETF1 GSPT2 | Eukaryotic Translation Termination |
| REAC:R-HSA-975956 | 6.02657683388e-05 | 1.0 | GSPT1 ETF1 GSPT2 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-975957 | 0.000105266822355 | 1.0 | GSPT1 ETF1 GSPT2 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.000105266822355 | 1.0 | GSPT1 ETF1 GSPT2 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-9010553 | 0.000348984315873 | 1.0 | GSPT1 ETF1 GSPT2 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-376176 | 0.00071395360032 | 1.0 | GSPT1 ETF1 GSPT2 | Signaling by ROBO receptors |
| WP:WP107 | 0.00117249358059 | 0.666666666667 | ETF1 GSPT2 | Translation Factors |
| REAC:R-HSA-72766 | 0.00180867442135 | 1.0 | GSPT1 ETF1 GSPT2 | Translation |
| GO:0008135 | 0.0051907357126 | 1.0 | GSPT1 ETF1 GSPT2 | translation factor activity, RNA binding |
| GO:0002181 | 0.00718184217333 | 1.0 | GSPT1 ETF1 GSPT2 | cytoplasmic translation |
| GO:0090079 | 0.00962631496557 | 1.0 | GSPT1 ETF1 GSPT2 | translation regulator activity, nucleic acid binding |
| REAC:R-HSA-422475 | 0.0100572742862 | 1.0 | GSPT1 ETF1 GSPT2 | Axon guidance |
| GO:0006415 | 0.0146853637429 | 1.0 | GSPT1 ETF1 GSPT2 | translational termination |
| GO:0045182 | 0.0196004650773 | 1.0 | GSPT1 ETF1 GSPT2 | translation regulator activity |
| REAC:R-HSA-8953854 | 0.0206735000409 | 1.0 | GSPT1 ETF1 GSPT2 | Metabolism of RNA |
| GO:0000184 | 0.0212638981157 | 1.0 | GSPT1 ETF1 GSPT2 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| GO:0006449 | 0.0378589948753 | 0.666666666667 | GSPT1 ETF1 | regulation of translational termination |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSPT2 | ETF1 | 0.783 | 0.756 | youn (ETF1) bioplex (GSPT2) bioplex_WMM youn_WMM gupta_WMM |
| GSPT2 | GSPT1 | 0.546 | 0.643 | bioplex (GSPT2) bioplex_WMM youn_WMM gupta_WMM |
| GSPT1 | ETF1 | 0.188 | 0.438 | hein_WMM youn (ETF1) bioplex_WMM youn_WMM hein (GSPT1) gupta_WMM |
Images
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Complex HuMAP2_06250 has an average edge precision of 0.612 which is ranked 1880 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ETF1 | HuMAP2_03606 HuMAP2_03670 HuMAP2_04153 HuMAP2_06250 HuMAP2_06475 |
| GSPT1 | HuMAP2_03606 HuMAP2_06250 HuMAP2_06475 |
| GSPT2 | HuMAP2_01706 HuMAP2_03606 HuMAP2_04134 HuMAP2_04153 HuMAP2_06250 HuMAP2_06475 |