hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06258
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BNIP1 | Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 1) (Transformation-related gene 8 protein) (TRG-8) | UniProt NCBI |
| USE1 | Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31) | UniProt NCBI |
| KNTC1 | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | UniProt NCBI |
| SCFD2 | Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1) | UniProt NCBI |
| STX18 | Syntaxin-18 (Cell growth-inhibiting gene 9 protein) | UniProt NCBI |
| NBAS | Neuroblastoma-amplified sequence (Neuroblastoma-amplified gene protein) | UniProt NCBI |
| RINT1 | RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) | UniProt NCBI |
| ZWILCH | Protein zwilch homolog (hZwilch) | UniProt NCBI |
| C19orf25 | UPF0449 protein C19orf25 | UniProt NCBI |
| ZW10 | Centromere/kinetochore protein zw10 homolog | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6811434 | 2.63373217189e-09 | 0.6 | RINT1 NBAS ZW10 USE1 BNIP1 STX18 | COPI-dependent Golgi-to-ER retrograde traffic |
| CORUM:7541 | 1.62176028613e-08 | 0.3 | KNTC1 ZWILCH ZW10 | KNTC1-ZW10-ZWILCH complex |
| REAC:R-HSA-8856688 | 1.68090641726e-08 | 0.6 | RINT1 NBAS ZW10 USE1 BNIP1 STX18 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-6811442 | 2.08628887551e-07 | 0.6 | RINT1 NBAS ZW10 USE1 BNIP1 STX18 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0006890 | 2.9771800713e-07 | 0.6 | RINT1 NBAS ZW10 USE1 BNIP1 STX18 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| GO:0070939 | 1.08982291228e-05 | 0.3 | RINT1 NBAS ZW10 | Dsl1/NZR complex |
| GO:1990423 | 1.08982291228e-05 | 0.3 | KNTC1 ZWILCH ZW10 | RZZ complex |
| KEGG:04130 | 5.1447142207e-05 | 0.3 | STX18 USE1 BNIP1 | SNARE interactions in vesicular transport |
| CORUM:705 | 9.0534767973e-05 | 0.2 | RINT1 ZW10 | SNARE complex (RINT1, ZW10, p31) |
| REAC:R-HSA-199991 | 0.000131991736486 | 0.6 | RINT1 NBAS ZW10 USE1 BNIP1 STX18 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00018094052648 | 0.6 | RINT1 NBAS ZW10 USE1 BNIP1 STX18 | Vesicle-mediated transport |
| GO:0048193 | 0.00112186351269 | 0.6 | RINT1 NBAS ZW10 USE1 BNIP1 STX18 | Golgi vesicle transport |
| REAC:R-HSA-141424 | 0.00554920449602 | 0.3 | KNTC1 ZWILCH ZW10 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.00554920449602 | 0.3 | KNTC1 ZWILCH ZW10 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-69618 | 0.00872437173154 | 0.3 | KNTC1 ZWILCH ZW10 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 0.012287626138 | 0.3 | KNTC1 ZWILCH ZW10 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.0166938467132 | 0.3 | KNTC1 ZWILCH ZW10 | RHO GTPases Activate Formins |
| REAC:R-HSA-2467813 | 0.0429900480963 | 0.3 | KNTC1 ZWILCH ZW10 | Separation of Sister Chromatids |
| REAC:R-HSA-68882 | 0.0487734821247 | 0.3 | KNTC1 ZWILCH ZW10 | Mitotic Anaphase |
| REAC:R-HSA-68877 | 0.0487734821247 | 0.3 | KNTC1 ZWILCH ZW10 | Mitotic Prometaphase |
| REAC:R-HSA-2555396 | 0.0495300972407 | 0.3 | KNTC1 ZWILCH ZW10 | Mitotic Metaphase and Anaphase |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RINT1 | ZW10 | 1.0 | 0.949 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM hein (ZW10) gupta_WMM |
| KNTC1 | ZW10 | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) Malo fraction boldt_WMM |
| BNIP1 | STX18 | 0.999 | 0.945 | hein_WMM bioplex (STX18) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NBAS | STX18 | 0.997 | 0.93 | hein_WMM bioplex (STX18) bioplex_WMM youn_WMM |
| STX18 | ZW10 | 0.995 | 0.924 | hein_WMM bioplex (STX18) bioplex_WMM boldt youn_WMM hein (ZW10) boldt_WMM |
| USE1 | ZW10 | 0.984 | 0.899 | hein_WMM bioplex (USE1) bioplex_WMM youn_WMM hein (ZW10) |
| USE1 | NBAS | 0.983 | 0.899 | hein_WMM bioplex (USE1) bioplex_WMM youn_WMM |
| USE1 | SCFD2 | 0.88 | 0.813 | hein_WMM bioplex (SCFD2,USE1) bioplex_WMM youn_WMM |
| SCFD2 | ZW10 | 0.849 | 0.79 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM hein (ZW10) |
| RINT1 | NBAS | 0.8 | 0.766 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM |
| SCFD2 | NBAS | 0.764 | 0.748 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM |
| C19orf25 | ZW10 | 0.7 | 0.722 | hein_WMM bioplex_WMM hein (ZW10) gupta_WMM |
| USE1 | STX18 | 0.6 | 0.67 | hein_WMM bioplex (STX18,USE1) bioplex_WMM youn_WMM gupta_WMM |
| RINT1 | C19orf25 | 0.559 | 0.65 | hein_WMM bioplex (RINT1) bioplex_WMM gupta_WMM |
| SCFD2 | RINT1 | 0.374 | 0.546 | hein_WMM bioplex (RINT1,SCFD2) bioplex_WMM youn_WMM |
| USE1 | RINT1 | 0.299 | 0.497 | hein_WMM bioplex (RINT1,USE1) bioplex_WMM youn_WMM |
| BNIP1 | ZW10 | 0.165 | 0.42 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) |
| SCFD2 | BNIP1 | 0.116 | 0.389 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM |
| NBAS | ZW10 | 0.114 | 0.384 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) |
| SCFD2 | C19orf25 | 0.08 | 0.35 | hein_WMM bioplex (SCFD2) bioplex_WMM |
| RINT1 | STX18 | 0.078 | 0.353 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM |
| SCFD2 | STX18 | 0.065 | 0.348 | hein_WMM bioplex (SCFD2) bioplex_WMM youn_WMM |
| ZW10 | ZWILCH | 0.06 | 0.335 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) |
| RINT1 | BNIP1 | 0.051 | 0.3 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM |
| USE1 | BNIP1 | 0.02 | 0.188 | hein_WMM bioplex (USE1) bioplex_WMM youn_WMM gupta_WMM |
| BNIP1 | NBAS | 0.015 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NBAS | C19orf25 | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| KNTC1 | RINT1 | 0.011 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| RINT1 | ZWILCH | 0.009 | 0.109 | hein_WMM bioplex_WMM WMM_only |
| KNTC1 | ZWILCH | 0.009 | 0.104 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| C19orf25 | ZWILCH | 0.008 | 0.09 | hein_WMM bioplex_WMM WMM_only |
| BNIP1 | ZWILCH | 0.008 | 0.083 | hein_WMM WMM_only |
| SCFD2 | ZWILCH | 0.008 | 0.083 | hein_WMM WMM_only |
| USE1 | ZWILCH | 0.008 | 0.083 | hein_WMM WMM_only |
| BNIP1 | C19orf25 | 0.008 | 0.031 | hein_WMM bioplex_WMM WMM_only |
| KNTC1 | C19orf25 | 0.008 | 0.034 | hein_WMM bioplex_WMM WMM_only |
| KNTC1 | SCFD2 | 0.008 | 0.033 | hein_WMM youn_WMM WMM_only |
| NBAS | ZWILCH | 0.008 | 0.023 | hein_WMM WMM_only |
| KNTC1 | USE1 | 0.008 | 0.023 | hein_WMM WMM_only |
| KNTC1 | BNIP1 | 0.008 | 0.023 | hein_WMM WMM_only |
| C19orf25 | STX18 | 0.008 | 0.029 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| STX18 | ZWILCH | 0.007 | 0.004 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KNTC1 | NBAS | 0.007 | 0.006 | hein_WMM WMM_only |
| KNTC1 | STX18 | 0.007 | 0.005 | hein_WMM bioplex_WMM WMM_only |
| USE1 | C19orf25 | 0.0 | 0.014 | hein_WMM bioplex (USE1) bioplex_WMM |
Images
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Complex HuMAP2_06258 has an average edge precision of 0.377 which is ranked 3560 out of all 6965 complexes.
Related Complexes