hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06259
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BBOX1 | Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase) | UniProt NCBI |
| AZI2 | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (TILP) | UniProt NCBI |
| CASP2 | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | UniProt NCBI |
| TBKBP1 | TANK-binding kinase 1-binding protein 1 (TBK1-binding protein 1) | UniProt NCBI |
| CHRDL1 | Chordin-like protein 1 (Neuralin-1) (Neurogenesin-1) (Ventroptin) | UniProt NCBI |
| MTPAP | Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP) | UniProt NCBI |
| TBK1 | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) | UniProt NCBI |
| CALCOCO2 | Calcium-binding and coiled-coil domain-containing protein 2 (Antigen nuclear dot 52 kDa protein) (Nuclear domain 10 protein NDP52) (Nuclear domain 10 protein 52) (Nuclear dot protein 52) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5212 | 2.63378327565e-07 | 0.375 | TBK1 AZI2 TBKBP1 | Kinase maturation complex 2 |
| WP:WP3865 | 0.000126050290821 | 0.375 | TBK1 AZI2 TBKBP1 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:04622 | 0.000200636818548 | 0.375 | TBK1 AZI2 TBKBP1 | RIG-I-like receptor signaling pathway |
| KEGG:04137 | 0.0225849529429 | 0.25 | TBK1 CALCOCO2 | Mitophagy - animal |
| CORUM:129 | 0.0497224828424 | 0.125 | CASP2 | PIDDsome complex |
| CORUM:7405 | 0.0497224828424 | 0.125 | TBK1 | TMEM173-TBK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BBOX1 | CASP2 | 0.983 | 0.899 | bioplex (BBOX1) bioplex_WMM |
| BBOX1 | AZI2 | 0.598 | 0.668 | bioplex (BBOX1) bioplex_WMM |
| CALCOCO2 | AZI2 | 0.553 | 0.646 | bioplex (CALCOCO2) bioplex_WMM |
| BBOX1 | TBK1 | 0.453 | 0.594 | bioplex (BBOX1) bioplex_WMM |
| CALCOCO2 | MTPAP | 0.093 | 0.355 | bioplex (CALCOCO2) bioplex_WMM |
| TBK1 | TBKBP1 | 0.073 | 0.356 | youn (TBK1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CALCOCO2 | TBK1 | 0.046 | 0.293 | bioplex (CALCOCO2) bioplex_WMM |
| CALCOCO2 | TBKBP1 | 0.039 | 0.266 | bioplex (CALCOCO2) bioplex_WMM |
| CALCOCO2 | CHRDL1 | 0.021 | 0.184 | bioplex (CHRDL1) bioplex_WMM |
| AZI2 | TBK1 | 0.014 | 0.138 | youn (TBK1) bioplex_WMM youn_WMM |
| AZI2 | TBKBP1 | 0.009 | 0.098 | bioplex_WMM youn_WMM WMM_only |
| CASP2 | AZI2 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| MTPAP | TBKBP1 | 0.008 | 0.041 | bioplex_WMM youn_WMM WMM_only |
| CASP2 | TBK1 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| MTPAP | AZI2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CALCOCO2 | CASP2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| MTPAP | TBK1 | 0.007 | 0.001 | bioplex_WMM youn_WMM WMM_only |
| CALCOCO2 | BBOX1 | 0.0 | 0.003 | bioplex (BBOX1) bioplex_WMM |
Images
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Complex HuMAP2_06259 has an average edge precision of 0.26 which is ranked 5229 out of all 6965 complexes.
Related Complexes