hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06263
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ALDH1B1 | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) | UniProt NCBI |
| ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) | UniProt NCBI |
| ALDH2 | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | UniProt NCBI |
| PEPD | Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) | UniProt NCBI |
| PRCP | Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) | UniProt NCBI |
| PHGDH | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | UniProt NCBI |
| ALDH1A2 | Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) | UniProt NCBI |
| GAA | Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase] | UniProt NCBI |
| OAT | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form] | UniProt NCBI |
| SHMT2 | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | UniProt NCBI |
| IGHG4 | NCBI | |
| ME2 | NAD-dependent malic enzyme, mitochondrial (NAD-ME) (EC 1.1.1.38) (Malic enzyme 2) | UniProt NCBI |
| ME1 | NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01200 | 8.2957884418e-07 | 0.416666666667 | ALDH6A1 ME1 ME2 SHMT2 PHGDH | Carbon metabolism |
| KEGG:00620 | 8.89458130017e-07 | 0.333333333333 | ME1 ME2 ALDH2 ALDH1B1 | Pyruvate metabolism |
| KEGG:01100 | 2.0155416296e-06 | 0.75 | PHGDH ALDH1B1 SHMT2 ME1 OAT ALDH1A2 ALDH6A1 ALDH2 GAA | Metabolic pathways |
| GO:0044281 | 4.67331557331e-06 | 0.916666666667 | PHGDH GAA PEPD SHMT2 ME1 ME2 OAT ALDH1A2 ALDH6A1 ALDH2 ALDH1B1 | small molecule metabolic process |
| GO:0050662 | 3.98404622434e-05 | 0.5 | ALDH1B1 SHMT2 ALDH2 OAT ALDH6A1 ME1 | coenzyme binding |
| KEGG:00410 | 7.28471539781e-05 | 0.25 | ALDH6A1 ALDH2 ALDH1B1 | beta-Alanine metabolism |
| KEGG:00280 | 0.0002887043558 | 0.25 | ALDH6A1 ALDH2 ALDH1B1 | Valine, leucine and isoleucine degradation |
| REAC:R-HSA-1430728 | 0.000292591282757 | 0.75 | PHGDH ALDH1B1 SHMT2 ME2 ME1 OAT ALDH6A1 ALDH2 GAA | Metabolism |
| KEGG:00330 | 0.000307811576824 | 0.25 | ALDH1B1 ALDH2 OAT | Arginine and proline metabolism |
| GO:0016620 | 0.000375577996617 | 0.333333333333 | ALDH6A1 ALDH1A2 ALDH2 ALDH1B1 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| GO:0048037 | 0.00103054185396 | 0.5 | ALDH1B1 SHMT2 ALDH2 OAT ALDH6A1 ME1 | cofactor binding |
| GO:0016903 | 0.0012036047613 | 0.333333333333 | ALDH6A1 ALDH1A2 ALDH2 ALDH1B1 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0019752 | 0.0016269323781 | 0.666666666667 | PHGDH ME2 SHMT2 PEPD OAT ALDH1A2 ALDH6A1 ME1 | carboxylic acid metabolic process |
| WP:WP4018 | 0.00213350484968 | 0.25 | ME1 SHMT2 PHGDH | Pathways in clear cell renal cell carcinoma |
| GO:0043436 | 0.0031189651301 | 0.666666666667 | PHGDH ME2 SHMT2 PEPD OAT ALDH1A2 ALDH6A1 ME1 | oxoacid metabolic process |
| GO:0006082 | 0.00349322087282 | 0.666666666667 | PHGDH ME2 SHMT2 PEPD OAT ALDH1A2 ALDH6A1 ME1 | organic acid metabolic process |
| GO:0016491 | 0.00361193197697 | 0.583333333333 | PHGDH ME2 ALDH2 ALDH1A2 ALDH6A1 ME1 ALDH1B1 | oxidoreductase activity |
| KEGG:00340 | 0.00459037429893 | 0.166666666667 | ALDH2 ALDH1B1 | Histidine metabolism |
| GO:0004029 | 0.0056884522543 | 0.25 | ALDH1A2 ALDH2 ALDH1B1 | aldehyde dehydrogenase (NAD) activity |
| REAC:R-HSA-71384 | 0.00644520730531 | 0.166666666667 | ALDH2 ALDH1B1 | Ethanol oxidation |
| KEGG:00053 | 0.00677945434364 | 0.166666666667 | ALDH2 ALDH1B1 | Ascorbate and aldarate metabolism |
| GO:0043648 | 0.0134822843571 | 0.333333333333 | ME1 ME2 OAT SHMT2 | dicarboxylic acid metabolic process |
| WP:WP3996 | 0.0160634011036 | 0.166666666667 | ALDH1A2 ALDH2 | Ethanol effects on histone modifications |
| GO:0005759 | 0.0166053748452 | 0.5 | ALDH1B1 ME2 SHMT2 OAT ALDH6A1 ALDH2 | mitochondrial matrix |
| WP:WP2525 | 0.0172030833908 | 0.166666666667 | SHMT2 PHGDH | Trans-sulfuration and one carbon metabolism |
| GO:0009055 | 0.0175674195014 | 0.333333333333 | ME1 ME2 ALDH2 PHGDH | electron transfer activity |
| KEGG:00380 | 0.0177348042591 | 0.166666666667 | ALDH2 ALDH1B1 | Tryptophan metabolism |
| GO:0003824 | 0.0193743542584 | 1.0 | PRCP GAA PHGDH PEPD SHMT2 ME1 ME2 OAT ALDH1A2 ALDH6A1 ALDH2 ALDH1B1 | catalytic activity |
| KEGG:00260 | 0.0197143077999 | 0.166666666667 | SHMT2 PHGDH | Glycine, serine and threonine metabolism |
| KEGG:00071 | 0.0228761648372 | 0.166666666667 | ALDH2 ALDH1B1 | Fatty acid degradation |
| KEGG:00000 | 0.0230781193683 | 0.916666666667 | PRCP GAA PHGDH SHMT2 ME2 ME1 OAT ALDH1A2 ALDH6A1 ALDH2 ALDH1B1 | KEGG root term |
| WP:WP465 | 0.0277023711436 | 0.166666666667 | ALDH1A2 ALDH2 | Tryptophan metabolism |
| KEGG:00561 | 0.0392264664521 | 0.166666666667 | ALDH2 ALDH1B1 | Glycerolipid metabolism |
| GO:0051287 | 0.040056393586 | 0.25 | ME1 ALDH2 ALDH1B1 | NAD binding |
| KEGG:00310 | 0.0482100335358 | 0.166666666667 | ALDH2 ALDH1B1 | Lysine degradation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALDH2 | ALDH6A1 | 1.0 | 0.949 | bioplex (ALDH2) bioplex_WMM fraction |
| OAT | GAA | 0.988 | 0.901 | bioplex (GAA) bioplex_WMM fraction |
| ALDH2 | GAA | 0.983 | 0.899 | bioplex_WMM fraction |
| PEPD | GAA | 0.882 | 0.816 | bioplex_WMM fraction |
| ALDH6A1 | PEPD | 0.877 | 0.811 | fraction |
| GAA | PHGDH | 0.843 | 0.788 | bioplex (GAA) bioplex_WMM fraction boldt_WMM |
| GAA | ALDH1B1 | 0.832 | 0.779 | bioplex (GAA) bioplex_WMM fraction |
| ALDH2 | ME2 | 0.816 | 0.773 | bioplex_WMM fraction |
| ALDH2 | PEPD | 0.709 | 0.728 | bioplex_WMM fraction treiber_WMM |
| OAT | SHMT2 | 0.696 | 0.718 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| GAA | ME1 | 0.59 | 0.664 | bioplex_WMM fraction |
| ALDH6A1 | ALDH1B1 | 0.572 | 0.655 | bioplex_WMM fraction |
| PRCP | OAT | 0.558 | 0.649 | bioplex_WMM fraction |
| OAT | ALDH1B1 | 0.479 | 0.613 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| ALDH2 | PHGDH | 0.473 | 0.608 | bioplex (ALDH2) bioplex_WMM gupta_WMM fraction treiber_WMM |
| ALDH2 | SHMT2 | 0.351 | 0.538 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| PEPD | ALDH1B1 | 0.331 | 0.521 | bioplex_WMM fraction treiber_WMM |
| OAT | ALDH6A1 | 0.299 | 0.498 | bioplex_WMM gupta_WMM fraction |
| ALDH2 | ALDH1A2 | 0.292 | 0.493 | bioplex (ALDH2) bioplex_WMM |
| PEPD | SHMT2 | 0.249 | 0.472 | bioplex_WMM fraction treiber_WMM |
| ALDH2 | OAT | 0.194 | 0.447 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| ALDH6A1 | PHGDH | 0.185 | 0.44 | bioplex_WMM gupta_WMM fraction |
| OAT | ME1 | 0.154 | 0.415 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| ALDH2 | ME1 | 0.146 | 0.409 | bioplex_WMM fraction |
| ME2 | GAA | 0.138 | 0.407 | bioplex_WMM fraction |
| OAT | PHGDH | 0.118 | 0.393 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| ALDH2 | IGHG4 | 0.106 | 0.374 | bioplex (ALDH2) bioplex_WMM |
| ALDH1B1 | PHGDH | 0.061 | 0.336 | bioplex (ALDH1B1) bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| ME2 | PHGDH | 0.055 | 0.311 | youn_WMM fraction |
| SHMT2 | ME1 | 0.052 | 0.3 | bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| PRCP | PEPD | 0.05 | 0.298 | bioplex_WMM fraction |
| ALDH2 | PRCP | 0.044 | 0.279 | bioplex_WMM fraction |
| GAA | SHMT2 | 0.031 | 0.242 | bioplex_WMM fraction |
| OAT | PEPD | 0.031 | 0.238 | bioplex_WMM fraction treiber_WMM |
| ALDH2 | ALDH1B1 | 0.026 | 0.219 | bioplex (ALDH1B1,ALDH2) bioplex_WMM treiber_WMM |
| ME2 | ALDH1B1 | 0.023 | 0.207 | bioplex_WMM youn_WMM fraction |
| ME2 | SHMT2 | 0.021 | 0.185 | bioplex_WMM youn_WMM fraction |
| ALDH6A1 | ME1 | 0.013 | 0.149 | fraction |
| ME2 | OAT | 0.013 | 0.152 | bioplex_WMM youn_WMM fraction |
| ALDH1A2 | ALDH6A1 | 0.009 | 0.099 | bioplex_WMM gupta_WMM WMM_only |
| IGHG4 | ALDH6A1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| ALDH1A2 | ALDH1B1 | 0.008 | 0.085 | bioplex (ALDH1B1) bioplex_WMM youn_WMM gupta_WMM |
| ME2 | PRCP | 0.008 | 0.042 | bioplex_WMM fraction |
| IGHG4 | ALDH1A2 | 0.008 | 0.034 | bioplex_WMM WMM_only |
| ALDH1A2 | PHGDH | 0.007 | 0.008 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ALDH1A2 | ME1 | 0.007 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| IGHG4 | ALDH1B1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| IGHG4 | PHGDH | 0.007 | 0.005 | boldt boldt_WMM |
| ALDH1A2 | SHMT2 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ALDH1A2 | OAT | 0.007 | 0.003 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ALDH1A2 | GAA | 0.007 | 0.002 | bioplex_WMM WMM_only |
| ALDH1A2 | PEPD | 0.007 | 0.003 | bioplex_WMM WMM_only |
| ALDH1A2 | PRCP | 0.007 | 0.0 | bioplex_WMM WMM_only |
| ALDH1B1 | ME1 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| ME2 | ME1 | 0.007 | 0.0 | youn_WMM WMM_only |
| ME2 | ALDH1A2 | 0.007 | 0.001 | bioplex_WMM youn_WMM WMM_only |
| PRCP | GAA | 0.007 | 0.003 | bioplex (GAA) bioplex_WMM fraction |
| PRCP | ALDH1B1 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| PEPD | ME1 | 0.004 | 0.012 | bioplex_WMM fraction |
| PRCP | SHMT2 | 0.004 | 0.013 | bioplex_WMM fraction |
| PHGDH | ME1 | 0.003 | 0.013 | youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| PRCP | ME1 | 0.003 | 0.005 | bioplex_WMM fraction |
| ALDH6A1 | SHMT2 | 0.0 | 0.006 | bioplex_WMM gupta_WMM fraction |
| ME2 | PEPD | 0.0 | 0.009 | bioplex_WMM fraction |
| PRCP | ALDH6A1 | 0.0 | 0.017 | fraction |
| PEPD | PHGDH | 0.0 | 0.009 | fraction treiber_WMM |
| PRCP | PHGDH | 0.0 | 0.01 | bioplex_WMM fraction |
| ALDH1B1 | SHMT2 | 0.0 | 0.003 | bioplex (ALDH1B1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| PHGDH | SHMT2 | 0.0 | 0.001 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_06263 has an average edge precision of 0.292 which is ranked 4719 out of all 6965 complexes.
Related Complexes