hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06268
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPP6R3 | Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL) | UniProt NCBI |
| PPP6R2 | Serine/threonine-protein phosphatase 6 regulatory subunit 2 (SAPS domain family member 2) | UniProt NCBI |
| PPP6R1 | Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1) | UniProt NCBI |
| PRORP | Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) | UniProt NCBI |
| AKR1B1 | Aldo-keto reductase family 1 member B1 (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) (EC 1.1.1.21) | UniProt NCBI |
| USP10 | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | UniProt NCBI |
| PPP6C | Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed] | UniProt NCBI |
| ANKRD28 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) | UniProt NCBI |
| TIMP3 | Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) | UniProt NCBI |
| ANKRD52 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52) | UniProt NCBI |
| NOTCH2 | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | UniProt NCBI |
| ANKRD44 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) | UniProt NCBI |
| NOTCH3 | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5196 | 9.85206310772e-09 | 0.307692307692 | ANKRD28 PPP6R1 PPP6C PPP6R2 | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) |
| REAC:R-HSA-204005 | 4.23677548486e-05 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | COPII-mediated vesicle transport |
| REAC:R-HSA-199977 | 0.00133963029476 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-5083630 | 0.00168001454651 | 0.153846153846 | NOTCH3 NOTCH2 | Defective LFNG causes SCDO3 |
| REAC:R-HSA-1912399 | 0.00251878091616 | 0.153846153846 | NOTCH3 NOTCH2 | Pre-NOTCH Processing in the Endoplasmic Reticulum |
| REAC:R-HSA-948021 | 0.0025265024376 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | Transport to the Golgi and subsequent modification |
| WP:WP3971 | 0.00323904092762 | 0.153846153846 | NOTCH3 NOTCH2 | Role of Osx and miRNAs in tooth development |
| GO:0048207 | 0.00827822507569 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | vesicle targeting, rough ER to cis-Golgi |
| GO:0048208 | 0.00827822507569 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | COPII vesicle coating |
| GO:0006901 | 0.010765426249 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | vesicle coating |
| GO:0090114 | 0.0121996110402 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | COPII-coated vesicle budding |
| WP:WP3845 | 0.0134652699096 | 0.153846153846 | NOTCH3 NOTCH2 | Canonical and Non-canonical Notch signaling |
| GO:0048199 | 0.0137717183687 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | vesicle targeting, to, from or within Golgi |
| KEGG:05206 | 0.0154999924536 | 0.230769230769 | TIMP3 NOTCH2 NOTCH3 | MicroRNAs in cancer |
| GO:0048194 | 0.0183614143254 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | Golgi vesicle budding |
| REAC:R-HSA-446203 | 0.0195947027995 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-1912420 | 0.0255401751375 | 0.153846153846 | NOTCH3 NOTCH2 | Pre-NOTCH Processing in Golgi |
| GO:0006903 | 0.0323768018309 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | vesicle targeting |
| WP:WP268 | 0.035885296745 | 0.153846153846 | NOTCH3 NOTCH2 | Notch Signaling |
| KEGG:04330 | 0.0378995485294 | 0.153846153846 | NOTCH3 NOTCH2 | Notch signaling pathway |
| GO:0006900 | 0.0467039915804 | 0.307692307692 | PPP6R3 ANKRD28 PPP6C PPP6R1 | vesicle budding from membrane |
| HP:0002691 | 0.049704495568 | 0.153846153846 | NOTCH3 NOTCH2 | Platybasia |
| CORUM:3154 | 0.0499905325622 | 0.0769230769231 | NOTCH2 | Notch2(N-TM)-Notch2(N-EC)-Delta complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP6R1 | ANKRD44 | 1.0 | 0.949 | hein_WMM bioplex (ANKRD44) bioplex_WMM youn_WMM hein (PPP6R1) |
| ANKRD28 | PPP6R2 | 0.996 | 0.927 | hein_WMM bioplex (PPP6R2) bioplex_WMM youn_WMM hein (ANKRD28) gupta_WMM boldt_WMM |
| ANKRD28 | ANKRD44 | 0.982 | 0.897 | hein_WMM bioplex (ANKRD44) bioplex_WMM youn_WMM |
| PPP6C | ANKRD44 | 0.979 | 0.895 | hein_WMM bioplex (ANKRD44) bioplex_WMM youn_WMM hein (PPP6C) |
| PPP6C | PPP6R2 | 0.957 | 0.863 | hein_WMM bioplex (PPP6R2) bioplex_WMM youn_WMM hein (PPP6C) gupta_WMM boldt_WMM |
| ANKRD28 | PPP6R1 | 0.903 | 0.827 | hein_WMM bioplex_WMM boldt youn_WMM hein (ANKRD28,PPP6R1) gupta_WMM boldt_WMM |
| PPP6C | ANKRD28 | 0.897 | 0.822 | hein_WMM bioplex_WMM boldt youn_WMM hein (ANKRD28,PPP6C) gupta_WMM boldt_WMM |
| NOTCH2 | ANKRD44 | 0.873 | 0.805 | bioplex (ANKRD44) bioplex_WMM |
| PPP6C | PPP6R1 | 0.854 | 0.792 | hein_WMM bioplex_WMM boldt youn_WMM hein (PPP6C,PPP6R1) gupta_WMM boldt_WMM |
| ANKRD52 | PPP6R2 | 0.847 | 0.79 | hein_WMM bioplex (PPP6R2) bioplex_WMM youn_WMM gupta_WMM |
| PPP6R3 | PPP6C | 0.772 | 0.751 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (PPP6C) gupta_WMM fraction boldt_WMM |
| PPP6R3 | ANKRD28 | 0.686 | 0.712 | hein_WMM bioplex_WMM boldt youn_WMM hein (ANKRD28) gupta_WMM boldt_WMM |
| PPP6R2 | ANKRD44 | 0.449 | 0.593 | hein_WMM bioplex (ANKRD44,PPP6R2) bioplex_WMM youn_WMM |
| USP10 | ANKRD44 | 0.296 | 0.496 | youn (USP10) bioplex (USP10) bioplex_WMM youn_WMM |
| PPP6C | ANKRD52 | 0.235 | 0.469 | hein_WMM bioplex_WMM youn_WMM hein (PPP6C) gupta_WMM |
| ANKRD52 | PPP6R1 | 0.149 | 0.411 | hein_WMM bioplex_WMM youn_WMM hein (PPP6R1) gupta_WMM |
| ANKRD44 | NOTCH3 | 0.083 | 0.351 | bioplex (ANKRD44) bioplex_WMM |
| USP10 | ANKRD52 | 0.077 | 0.353 | youn (USP10) bioplex (USP10) bioplex_WMM youn_WMM |
| PPP6R3 | ANKRD44 | 0.058 | 0.328 | hein_WMM bioplex (ANKRD44) bioplex_WMM youn_WMM |
| ANKRD28 | ANKRD52 | 0.047 | 0.293 | hein_WMM bioplex_WMM youn_WMM hein (ANKRD28) gupta_WMM |
| PPP6C | PRORP | 0.038 | 0.263 | hein_WMM bioplex_WMM hein (PPP6C) gupta_WMM |
| ANKRD28 | USP10 | 0.037 | 0.265 | youn (USP10) bioplex (USP10) bioplex_WMM youn_WMM gupta_WMM |
| NOTCH2 | AKR1B1 | 0.036 | 0.264 | fraction |
| PPP6R3 | PPP6R2 | 0.031 | 0.24 | hein_WMM bioplex (PPP6R2) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
| PPP6R3 | PPP6R1 | 0.024 | 0.214 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| USP10 | PPP6R2 | 0.023 | 0.21 | youn (USP10) bioplex (PPP6R2,USP10) bioplex_WMM youn_WMM gupta_WMM |
| AKR1B1 | TIMP3 | 0.02 | 0.185 | fraction |
| PPP6R1 | PPP6R2 | 0.018 | 0.182 | hein_WMM bioplex (PPP6R2) bioplex_WMM youn_WMM gupta_WMM |
| USP10 | PPP6R1 | 0.015 | 0.151 | youn (USP10) bioplex (USP10) bioplex_WMM youn_WMM gupta_WMM |
| ANKRD52 | ANKRD44 | 0.013 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NOTCH2 | NOTCH3 | 0.012 | 0.149 | bioplex_WMM gupta_WMM WMM_only |
| PPP6R3 | ANKRD52 | 0.011 | 0.143 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| PPP6R3 | USP10 | 0.01 | 0.119 | youn (USP10) bioplex (USP10) bioplex_WMM youn_WMM gupta_WMM |
| PPP6C | USP10 | 0.009 | 0.112 | youn (USP10) bioplex (USP10) bioplex_WMM youn_WMM gupta_WMM |
| ANKRD44 | PRORP | 0.008 | 0.062 | hein_WMM WMM_only |
| PPP6R2 | PRORP | 0.008 | 0.043 | hein_WMM bioplex_WMM WMM_only |
| ANKRD28 | PRORP | 0.008 | 0.035 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| ANKRD52 | PRORP | 0.008 | 0.023 | hein_WMM WMM_only |
| PPP6R1 | PRORP | 0.007 | 0.006 | hein_WMM bioplex_WMM WMM_only |
| PPP6C | NOTCH2 | 0.007 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PPP6R3 | PRORP | 0.007 | 0.008 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NOTCH2 | PPP6R2 | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| USP10 | AKR1B1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| NOTCH2 | ANKRD52 | 0.007 | 0.001 | youn_WMM WMM_only |
| USP10 | PRORP | 0.007 | 0.001 | bioplex_WMM youn_WMM WMM_only |
| PPP6C | AKR1B1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| NOTCH2 | USP10 | 0.007 | 0.002 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| USP10 | NOTCH3 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| PPP6R1 | AKR1B1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| PPP6R3 | AKR1B1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| ANKRD28 | AKR1B1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| NOTCH2 | PPP6R1 | 0.007 | 0.002 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AKR1B1 | PRORP | 0.007 | 0.002 | WMM_only treiber_WMM |
| NOTCH2 | PRORP | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PPP6C | NOTCH3 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| NOTCH2 | TIMP3 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| ANKRD44 | AKR1B1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| ANKRD52 | NOTCH3 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| ANKRD28 | TIMP3 | 0.007 | 0.004 | WMM_only bioplex_WMM |
| PPP6R2 | NOTCH3 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| PPP6R2 | AKR1B1 | 0.007 | 0.006 | bioplex (PPP6R2) |
| ANKRD28 | NOTCH2 | 0.007 | 0.002 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TIMP3 | NOTCH3 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| ANKRD28 | NOTCH3 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PPP6R1 | NOTCH3 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| PPP6R3 | NOTCH2 | 0.006 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PRORP | NOTCH3 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| PPP6R3 | NOTCH3 | 0.006 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06268 has an average edge precision of 0.239 which is ranked 5549 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PPP6R3 | HuMAP2_00665 HuMAP2_02481 HuMAP2_05435 HuMAP2_06268 |
| PPP6R2 | HuMAP2_02481 HuMAP2_03382 HuMAP2_04712 HuMAP2_05435 HuMAP2_06268 |
| PPP6R1 | HuMAP2_02481 HuMAP2_03741 HuMAP2_05435 HuMAP2_06268 |
| PRORP | HuMAP2_05435 HuMAP2_06268 |
| AKR1B1 | HuMAP2_06268 HuMAP2_06781 |
| USP10 | HuMAP2_01986 HuMAP2_02481 HuMAP2_05435 HuMAP2_06046 HuMAP2_06268 |
| PPP6C | HuMAP2_00665 HuMAP2_02481 HuMAP2_05435 HuMAP2_06268 |
| ANKRD28 | HuMAP2_00665 HuMAP2_02481 HuMAP2_05435 HuMAP2_06268 |
| TIMP3 | HuMAP2_06268 |
| ANKRD52 | HuMAP2_02481 HuMAP2_03382 HuMAP2_05435 HuMAP2_06268 |
| NOTCH2 | HuMAP2_01320 HuMAP2_03741 HuMAP2_06153 HuMAP2_06268 |
| ANKRD44 | HuMAP2_02481 HuMAP2_03741 HuMAP2_05435 HuMAP2_06153 HuMAP2_06268 |
| NOTCH3 | HuMAP2_06268 HuMAP2_06521 |