hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06269
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDZK1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3) | UniProt NCBI |
| ASNSD1 | Asparagine synthetase domain-containing protein 1 (HCV NS3-transactivated protein 1) | UniProt NCBI |
| SLC22A5 | Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2) | UniProt NCBI |
| SLC5A6 | Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) | UniProt NCBI |
| ABCC4 | Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) | UniProt NCBI |
| SLC19A3 | Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3) | UniProt NCBI |
| SH2D5 | SH2 domain-containing protein 5 | UniProt NCBI |
| SLC6A6 | Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2884 | 0.00111111767478 | 0.375 | SLC6A6 SLC5A6 ABCC4 | NRF2 pathway |
| GO:0042910 | 0.00111635111712 | 0.375 | SLC22A5 ABCC4 SLC6A6 | xenobiotic transmembrane transporter activity |
| KEGG:04977 | 0.00229500925537 | 0.25 | SLC19A3 SLC5A6 | Vitamin digestion and absorption |
| GO:0072337 | 0.0023070725905 | 0.375 | SLC22A5 SLC5A6 PDZK1 | modified amino acid transport |
| GO:0072348 | 0.0102394198288 | 0.375 | SLC6A6 SLC19A3 SLC5A6 | sulfur compound transport |
| WP:WP2882 | 0.0136528676271 | 0.375 | SLC6A6 SLC5A6 ABCC4 | Nuclear Receptors Meta-Pathway |
| REAC:R-HSA-425407 | 0.0181710734818 | 0.375 | SLC22A5 SLC5A6 SLC6A6 | SLC-mediated transmembrane transport |
| REAC:R-HSA-382551 | 0.028799368666 | 0.5 | ABCC4 SLC22A5 SLC5A6 SLC6A6 | Transport of small molecules |
| CORUM:7042 | 0.0497224828424 | 0.125 | PDZK1 | PDZK1-PLCB3- SSTR2 complex |
| CORUM:7043 | 0.0497224828424 | 0.125 | PDZK1 | PDZK1-PLCB3- SSTR3 complex |
| CORUM:7044 | 0.0497224828424 | 0.125 | PDZK1 | PDZK1-PLCB3- SSTR4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDZK1 | SH2D5 | 0.877 | 0.811 | bioplex (PDZK1) bioplex_WMM |
| PDZK1 | ABCC4 | 0.579 | 0.661 | bioplex (PDZK1) bioplex_WMM |
| PDZK1 | SLC19A3 | 0.298 | 0.498 | bioplex (PDZK1) bioplex_WMM |
| PDZK1 | ASNSD1 | 0.257 | 0.48 | bioplex (PDZK1) bioplex_WMM |
| PDZK1 | SLC6A6 | 0.163 | 0.42 | bioplex (PDZK1) bioplex_WMM |
| PDZK1 | SLC22A5 | 0.082 | 0.351 | bioplex (PDZK1) bioplex_WMM |
| PDZK1 | SLC5A6 | 0.024 | 0.214 | bioplex (PDZK1) bioplex_WMM |
| SH2D5 | SLC19A3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| SH2D5 | ABCC4 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| SH2D5 | ASNSD1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| SH2D5 | SLC22A5 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SH2D5 | SLC6A6 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| SLC19A3 | ABCC4 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SLC19A3 | ASNSD1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| SLC19A3 | SLC22A5 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ASNSD1 | ABCC4 | 0.008 | 0.058 | bioplex_WMM WMM_only |
| SLC6A6 | SLC19A3 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| SLC22A5 | ABCC4 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| SLC6A6 | SLC22A5 | 0.008 | 0.044 | bioplex_WMM gupta_WMM WMM_only |
| SLC22A5 | ASNSD1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| SLC6A6 | ABCC4 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| SLC6A6 | ASNSD1 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| SLC22A5 | SLC5A6 | 0.007 | 0.008 | bioplex_WMM gupta_WMM WMM_only |
| SH2D5 | SLC5A6 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| ABCC4 | SLC5A6 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| SLC6A6 | SLC5A6 | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| SLC19A3 | SLC5A6 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| ASNSD1 | SLC5A6 | 0.007 | 0.006 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06269 has an average edge precision of 0.157 which is ranked 6661 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDZK1 | HuMAP2_01486 HuMAP2_03516 HuMAP2_05538 HuMAP2_06269 |
| ASNSD1 | HuMAP2_01547 HuMAP2_01993 HuMAP2_03595 HuMAP2_05497 HuMAP2_06269 HuMAP2_06465 |
| SLC22A5 | HuMAP2_01486 HuMAP2_05430 HuMAP2_06269 |
| SLC5A6 | HuMAP2_06269 |
| ABCC4 | HuMAP2_05538 HuMAP2_06269 |
| SLC19A3 | HuMAP2_01486 HuMAP2_06269 |
| SH2D5 | HuMAP2_01486 HuMAP2_03516 HuMAP2_05538 HuMAP2_06269 |
| SLC6A6 | HuMAP2_01486 HuMAP2_05193 HuMAP2_06269 |