hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06271
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ACD | Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein) | UniProt NCBI |
| TERF1 | Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) | UniProt NCBI |
| TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | UniProt NCBI |
| TERF2 | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | UniProt NCBI |
| TINF2 | TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) | UniProt NCBI |
| POT1 | Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:138 | 4.09578169876e-21 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Telomere-associated protein complex |
| CORUM:1197 | 4.09578169876e-21 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Telomere-associated protein complex |
| CORUM:1204 | 2.86704718913e-20 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Rap1 complex |
| GO:0070187 | 3.3012000492e-18 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | shelterin complex |
| CORUM:1206 | 3.65872083369e-16 | 0.833333333333 | POT1 TERF2 TERF1 TINF2 TERF2IP | TRF-Rap1 complex I, 2MD |
| GO:0000783 | 3.05030884546e-15 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | nuclear telomere cap complex |
| GO:0000782 | 3.05030884546e-15 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | telomere cap complex |
| REAC:R-HSA-171306 | 1.94927312256e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Packaging Of Telomere Ends |
| REAC:R-HSA-110330 | 2.79543076619e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-110331 | 2.79543076619e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Cleavage of the damaged purine |
| REAC:R-HSA-73927 | 2.79543076619e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Depurination |
| REAC:R-HSA-110329 | 4.3808935679e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-73928 | 4.3808935679e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Depyrimidination |
| REAC:R-HSA-110328 | 4.3808935679e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| CORUM:1198 | 4.54011687692e-13 | 0.666666666667 | POT1 TERF2 ACD TINF2 | TIN2 complex |
| CORUM:1201 | 4.54011687692e-13 | 0.666666666667 | POT1 TERF1 ACD TINF2 | TRF1-TIN2 complex |
| CORUM:1207 | 4.54011687692e-13 | 0.666666666667 | POT1 TERF2 TINF2 TERF2IP | TRF2-Rap1 complex II |
| REAC:R-HSA-73929 | 4.87684378314e-13 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Base-Excision Repair, AP Site Formation |
| GO:0070198 | 1.56813604737e-12 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | protein localization to chromosome, telomeric region |
| REAC:R-HSA-1221632 | 2.17943657825e-12 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Meiotic synapsis |
| REAC:R-HSA-2559586 | 3.00855878491e-12 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-157579 | 3.51269566238e-12 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Telomere Maintenance |
| GO:0032205 | 5.35837587186e-12 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | negative regulation of telomere maintenance |
| REAC:R-HSA-73884 | 5.46571984656e-12 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Base Excision Repair |
| GO:0042162 | 6.43005104623e-12 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | telomeric DNA binding |
| REAC:R-HSA-73886 | 2.07115579658e-11 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Chromosome Maintenance |
| REAC:R-HSA-1500620 | 2.88657593408e-11 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Meiosis |
| REAC:R-HSA-1474165 | 5.59513298759e-11 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Reproduction |
| GO:0016233 | 7.57872341055e-11 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | telomere capping |
| GO:0007004 | 3.29445556545e-10 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | telomere maintenance via telomerase |
| GO:0006278 | 3.61327384598e-10 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | RNA-dependent DNA biosynthetic process |
| REAC:R-HSA-2559583 | 6.12339884991e-10 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Cellular Senescence |
| GO:0032204 | 7.21704855484e-10 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | regulation of telomere maintenance |
| GO:0032211 | 7.61406130455e-10 | 0.833333333333 | POT1 TERF2 TERF1 ACD TINF2 | negative regulation of telomere maintenance via telomerase |
| GO:0034502 | 8.47918498051e-10 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | protein localization to chromosome |
| GO:0010833 | 8.47918498051e-10 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | telomere maintenance via telomere lengthening |
| GO:0051053 | 2.8690986626e-09 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | negative regulation of DNA metabolic process |
| GO:1904357 | 3.96312010577e-09 | 0.833333333333 | POT1 TERF2 TERF1 ACD TINF2 | negative regulation of telomere maintenance via telomere lengthening |
| GO:2000279 | 6.9945924325e-09 | 0.833333333333 | POT1 TERF2 TERF1 ACD TINF2 | negative regulation of DNA biosynthetic process |
| GO:0000784 | 1.08779320075e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | nuclear chromosome, telomeric region |
| GO:2001251 | 1.26875796745e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | negative regulation of chromosome organization |
| REAC:R-HSA-73894 | 1.56912906071e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | DNA Repair |
| GO:0032993 | 2.71308225608e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | protein-DNA complex |
| GO:0000781 | 2.96436225998e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | chromosome, telomeric region |
| GO:0071897 | 3.5253704778e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | DNA biosynthetic process |
| GO:0000723 | 4.71972594968e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | telomere maintenance |
| REAC:R-HSA-2262752 | 6.58457028064e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Cellular responses to stress |
| GO:0098505 | 7.67964804112e-08 | 0.666666666667 | POT1 TERF1 TERF2IP TERF2 | G-rich strand telomeric DNA binding |
| GO:0032200 | 7.83505474636e-08 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | telomere organization |
| CORUM:2766 | 7.88270302729e-08 | 0.5 | TERF2 TINF2 TERF2IP | TERF2-RAP1 complex |
| GO:0032210 | 1.15162717077e-07 | 0.833333333333 | POT1 TERF2 TERF1 ACD TINF2 | regulation of telomere maintenance via telomerase |
| GO:0043047 | 1.80981361376e-07 | 0.666666666667 | POT1 TERF1 TERF2IP TERF2 | single-stranded telomeric DNA binding |
| GO:0098847 | 1.80981361376e-07 | 0.666666666667 | POT1 TERF1 TERF2IP TERF2 | sequence-specific single stranded DNA binding |
| REAC:R-HSA-8953897 | 1.96860593734e-07 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Cellular responses to external stimuli |
| GO:1904356 | 2.45328000896e-07 | 0.833333333333 | POT1 TERF2 TERF1 ACD TINF2 | regulation of telomere maintenance via telomere lengthening |
| REAC:R-HSA-1640170 | 8.1733071499e-07 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | Cell Cycle |
| GO:0051052 | 1.43261571772e-06 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | regulation of DNA metabolic process |
| GO:0098687 | 1.79593670521e-06 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | chromosomal region |
| GO:2000278 | 1.91660450295e-06 | 0.833333333333 | POT1 TERF2 TERF1 ACD TINF2 | regulation of DNA biosynthetic process |
| GO:0033044 | 1.91881244766e-06 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | regulation of chromosome organization |
| GO:0010639 | 1.96129538008e-06 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | negative regulation of organelle organization |
| GO:0060249 | 2.18565481651e-06 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | anatomical structure homeostasis |
| HP:0002894 | 4.15247751033e-06 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Neoplasm of the pancreas |
| GO:0032202 | 7.26438828159e-06 | 0.5 | POT1 ACD TINF2 | telomere assembly |
| CORUM:1205 | 8.39001385941e-06 | 0.333333333333 | TERF2IP TERF2 | TRF2-Rap1 complex III |
| HP:0000488 | 1.45393002531e-05 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Retinopathy |
| CORUM:1202 | 2.51655344529e-05 | 0.333333333333 | TERF1 TINF2 | TRF1 telomere length regulation complex |
| HP:0000958 | 3.18888121689e-05 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Dry skin |
| GO:0051129 | 5.36661004937e-05 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | negative regulation of cellular component organization |
| GO:0031848 | 0.000152436922042 | 0.5 | TERF2 ACD TERF2IP | protection from non-homologous end joining at telomere |
| GO:0061820 | 0.000152436922042 | 0.5 | POT1 TERF2 TERF1 | telomeric D-loop disassembly |
| CORUM:1193 | 0.000176032589326 | 0.333333333333 | TERF2IP TERF2 | Rap1 complex |
| HP:0001480 | 0.000213906300353 | 0.5 | POT1 ACD TERF2IP | Freckling |
| GO:0090657 | 0.000299339163023 | 0.5 | POT1 TERF2 TERF1 | telomeric loop disassembly |
| HP:0001732 | 0.000370401559893 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Abnormality of the pancreas |
| GO:0043247 | 0.00039905855691 | 0.5 | TERF2 ACD TERF2IP | telomere maintenance in response to DNA damage |
| GO:0006259 | 0.000579923761468 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | DNA metabolic process |
| HP:0006753 | 0.000585718024741 | 0.5 | POT1 ACD TERF2IP | Neoplasm of the stomach |
| HP:0002861 | 0.000617572732129 | 0.5 | POT1 ACD TERF2IP | Melanoma |
| GO:0033365 | 0.000908211665545 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | protein localization to organelle |
| GO:0043565 | 0.000937137248598 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | sequence-specific DNA binding |
| GO:0003697 | 0.00115360273212 | 0.666666666667 | POT1 TERF1 TERF2IP TERF2 | single-stranded DNA binding |
| HP:0100013 | 0.00124200653741 | 0.5 | POT1 ACD TERF2IP | Neoplasm of the breast |
| GO:0070200 | 0.00147880241807 | 0.5 | POT1 ACD TERF1 | establishment of protein localization to telomere |
| HP:0001000 | 0.00199789335791 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Abnormality of skin pigmentation |
| GO:0051276 | 0.00288133296855 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | chromosome organization |
| GO:0044454 | 0.00288133296855 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | nuclear chromosome part |
| GO:0033043 | 0.00309301270441 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | regulation of organelle organization |
| HP:0003764 | 0.0032158301853 | 0.5 | POT1 ACD TERF2IP | Nevus |
| GO:0000228 | 0.0033810209942 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | nuclear chromosome |
| GO:0045934 | 0.00502823107793 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | negative regulation of nucleobase-containing compound metabolic process |
| GO:0070199 | 0.00529364410104 | 0.5 | POT1 ACD TERF1 | establishment of protein localization to chromosome |
| GO:0032214 | 0.00676235117068 | 0.333333333333 | TERF1 TERF2 | negative regulation of telomere maintenance via semi-conservative replication |
| GO:0072695 | 0.00676235117068 | 0.333333333333 | TERF2IP TERF2 | regulation of DNA recombination at telomere |
| GO:1905778 | 0.00676235117068 | 0.333333333333 | TERF1 TERF2 | negative regulation of exonuclease activity |
| GO:1905777 | 0.00676235117068 | 0.333333333333 | TERF1 TERF2 | regulation of exonuclease activity |
| GO:0032213 | 0.00676235117068 | 0.333333333333 | TERF1 TERF2 | regulation of telomere maintenance via semi-conservative replication |
| GO:1905838 | 0.00676235117068 | 0.333333333333 | TERF1 TERF2 | regulation of telomeric D-loop disassembly |
| GO:0048239 | 0.00676235117068 | 0.333333333333 | TERF2IP TERF2 | negative regulation of DNA recombination at telomere |
| GO:1904534 | 0.00676235117068 | 0.333333333333 | TERF1 TERF2 | negative regulation of telomeric loop disassembly |
| GO:1905839 | 0.00676235117068 | 0.333333333333 | TERF1 TERF2 | negative regulation of telomeric D-loop disassembly |
| CORUM:0000000 | 0.0090785708022 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | CORUM root |
| HP:0100763 | 0.0100697018086 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Abnormality of the lymphatic system |
| GO:0042592 | 0.0109700934687 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | homeostatic process |
| HP:0025125 | 0.0128094019441 | 0.333333333333 | ACD TINF2 | White lesion of the oral mucosa |
| HP:0002745 | 0.0128094019441 | 0.333333333333 | ACD TINF2 | Oral leukoplakia |
| HP:0010450 | 0.0142301190129 | 0.333333333333 | ACD TINF2 | Esophageal stenosis |
| HP:0001915 | 0.0142301190129 | 0.333333333333 | ACD TINF2 | Aplastic anemia |
| GO:0044427 | 0.0151552637177 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | chromosomal part |
| GO:0003677 | 0.0183905219298 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | DNA binding |
| GO:0005694 | 0.0188325821521 | 1.0 | TERF1 POT1 TERF2 TINF2 TERF2IP ACD | chromosome |
| GO:1904533 | 0.020283420769 | 0.333333333333 | TERF1 TERF2 | regulation of telomeric loop disassembly |
| GO:0051972 | 0.0207293189685 | 0.5 | POT1 ACD TERF1 | regulation of telomerase activity |
| HP:0007378 | 0.0213861967068 | 0.5 | POT1 ACD TERF2IP | Neoplasm of the gastrointestinal tract |
| CORUM:2219 | 0.0249904952816 | 0.166666666667 | TERF1 | TERF1 homodimer complex |
| HP:0011355 | 0.0264290937445 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Localized skin lesion |
| HP:0011793 | 0.0279206634233 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Neoplasm by anatomical site |
| HP:0002071 | 0.0280983679133 | 0.5 | POT1 ACD TERF2IP | Abnormality of extrapyramidal motor function |
| HP:0002216 | 0.030358517586 | 0.333333333333 | ACD TINF2 | Premature graying of hair |
| GO:0016604 | 0.0320805527946 | 0.833333333333 | TERF1 TERF2 TERF2IP ACD TINF2 | nuclear body |
| HP:0000479 | 0.0322029678499 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Abnormal retinal morphology |
| HP:0007392 | 0.032521154219 | 0.333333333333 | ACD TINF2 | Excessive wrinkled skin |
| HP:0002664 | 0.0331529578102 | 0.666666666667 | POT1 TERF2IP ACD TINF2 | Neoplasm |
| HP:0011358 | 0.0394527338604 | 0.333333333333 | ACD TINF2 | Generalized hypopigmentation of hair |
| GO:1902576 | 0.0405595771497 | 0.333333333333 | TERF1 TERF2 | negative regulation of nuclear cell cycle DNA replication |
| HP:0011792 | 0.0421345110279 | 0.5 | POT1 ACD TERF2IP | Neoplasm by histology |
| HP:0007440 | 0.0497285764978 | 0.333333333333 | ACD TINF2 | Generalized hyperpigmentation |
| CORUM:1217 | 0.0499726005494 | 0.166666666667 | TERF2 | WRN-TRF2 complex |
| CORUM:1218 | 0.0499726005494 | 0.166666666667 | TERF2 | BLM-TRF2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TINF2 | TERF1 | 1.0 | 0.949 | hein_WMM bioplex (TERF1,TINF2) bioplex_WMM hein (TERF1) |
| TERF2IP | TERF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (TERF2,TERF2IP) Malo fraction |
| ACD | POT1 | 1.0 | 0.949 | hein_WMM bioplex (ACD,POT1) bioplex_WMM hein (POT1) |
| TINF2 | POT1 | 0.999 | 0.949 | hein_WMM bioplex (POT1,TINF2) bioplex_WMM hein (POT1) |
| TERF1 | POT1 | 0.999 | 0.949 | hein_WMM bioplex (POT1,TERF1) bioplex_WMM hein (POT1,TERF1) |
| TERF1 | ACD | 0.972 | 0.886 | hein_WMM bioplex (TERF1) bioplex_WMM hein (TERF1) |
| POT1 | TERF2 | 0.839 | 0.783 | hein_WMM bioplex (POT1) bioplex_WMM hein (POT1) |
| TINF2 | ACD | 0.709 | 0.728 | hein_WMM bioplex (ACD,TINF2) bioplex_WMM |
| POT1 | TERF2IP | 0.651 | 0.69 | hein_WMM bioplex (POT1) bioplex_WMM hein (POT1,TERF2IP) |
| ACD | TERF2IP | 0.154 | 0.414 | hein_WMM bioplex (ACD) bioplex_WMM hein (TERF2IP) |
| TINF2 | TERF2IP | 0.113 | 0.383 | hein_WMM bioplex (TINF2) bioplex_WMM |
| TINF2 | TERF2 | 0.088 | 0.353 | hein_WMM bioplex (TINF2) bioplex_WMM |
| TERF1 | TERF2 | 0.083 | 0.35 | hein_WMM bioplex_WMM hein (TERF1) |
| TERF1 | TERF2IP | 0.047 | 0.293 | hein_WMM bioplex (TERF1) bioplex_WMM hein (TERF1) |
| ACD | TERF2 | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06271 has an average edge precision of 0.651 which is ranked 1646 out of all 6965 complexes.
Related Complexes