hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06277
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NCBP1 | Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) | UniProt NCBI |
| NCBP2 | Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) | UniProt NCBI |
| SRRT | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | UniProt NCBI |
| PHAX | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) | UniProt NCBI |
| LENG1 | Leukocyte receptor cluster member 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1174 | 1.35146690511e-09 | 0.6 | NCBP1 PHAX NCBP2 | PHAX-CBC complex (cap binding complex) |
| CORUM:1176 | 1.35119464053e-08 | 0.6 | NCBP1 PHAX NCBP2 | CRM1-RAN-PHAX-CBC complex (cap binding complex) |
| REAC:R-HSA-6807505 | 4.18631702235e-07 | 0.8 | SRRT NCBP1 PHAX NCBP2 | RNA polymerase II transcribes snRNA genes |
| CORUM:1172 | 6.70868171695e-06 | 0.4 | NCBP1 NCBP2 | CBC complex (cap binding complex) |
| CORUM:775 | 6.70868171695e-06 | 0.4 | NCBP1 NCBP2 | CBC complex (cap binding complex) |
| REAC:R-HSA-194441 | 5.30427262701e-05 | 0.6 | NCBP1 PHAX NCBP2 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 5.30427262701e-05 | 0.6 | NCBP1 PHAX NCBP2 | snRNP Assembly |
| CORUM:6129 | 0.000100576175246 | 0.4 | NCBP1 NCBP2 | CBP80/20- dependent translation complex |
| GO:0042795 | 0.000111444253056 | 0.8 | SRRT NCBP1 PHAX NCBP2 | snRNA transcription by RNA polymerase II |
| GO:0009301 | 0.000118091273647 | 0.8 | SRRT NCBP1 PHAX NCBP2 | snRNA transcription |
| GO:0098781 | 0.000495430747346 | 0.8 | SRRT NCBP1 PHAX NCBP2 | ncRNA transcription |
| KEGG:03013 | 0.000498609547209 | 0.6 | NCBP1 PHAX NCBP2 | RNA transport |
| CORUM:351 | 0.000596572408668 | 0.6 | SRRT NCBP1 NCBP2 | Spliceosome |
| REAC:R-HSA-111367 | 0.000606744453221 | 0.4 | NCBP1 NCBP2 | SLBP independent Processing of Histone Pre-mRNAs |
| REAC:R-HSA-77588 | 0.000741476933235 | 0.4 | NCBP1 NCBP2 | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| REAC:R-HSA-8851708 | 0.00230284247734 | 0.4 | NCBP1 NCBP2 | Signaling by FGFR2 IIIa TM |
| REAC:R-HSA-77595 | 0.00230284247734 | 0.4 | NCBP1 NCBP2 | Processing of Intronless Pre-mRNAs |
| REAC:R-HSA-72163 | 0.00246885319177 | 0.6 | SRRT NCBP1 NCBP2 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-8953854 | 0.00262978456954 | 0.8 | SRRT NCBP1 PHAX NCBP2 | Metabolism of RNA |
| REAC:R-HSA-72172 | 0.00281668881241 | 0.6 | SRRT NCBP1 NCBP2 | mRNA Splicing |
| REAC:R-HSA-167242 | 0.00340529843133 | 0.4 | NCBP1 NCBP2 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| REAC:R-HSA-1839126 | 0.0040368179849 | 0.4 | NCBP1 NCBP2 | FGFR2 mutant receptor activation |
| REAC:R-HSA-6803529 | 0.00437263170532 | 0.4 | NCBP1 NCBP2 | FGFR2 alternative splicing |
| GO:0005846 | 0.00450823411379 | 0.4 | NCBP1 NCBP2 | nuclear cap binding complex |
| GO:0006408 | 0.00450823411379 | 0.4 | NCBP2 PHAX | snRNA export from nucleus |
| REAC:R-HSA-75067 | 0.00508433997358 | 0.4 | NCBP1 NCBP2 | Processing of Capped Intronless Pre-mRNA |
| REAC:R-HSA-72086 | 0.00546022370076 | 0.4 | NCBP1 NCBP2 | mRNA Capping |
| REAC:R-HSA-72203 | 0.00567167369058 | 0.6 | SRRT NCBP1 NCBP2 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-159227 | 0.00584945327803 | 0.4 | NCBP1 NCBP2 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-159230 | 0.00625202329777 | 0.4 | NCBP1 NCBP2 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-113418 | 0.00709716303977 | 0.4 | NCBP1 NCBP2 | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 0.00709716303977 | 0.4 | NCBP1 NCBP2 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-5655253 | 0.0075397219523 | 0.4 | NCBP1 NCBP2 | Signaling by FGFR2 in disease |
| REAC:R-HSA-159231 | 0.00894729002053 | 0.4 | NCBP1 NCBP2 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.00944309181669 | 0.4 | NCBP1 NCBP2 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-167169 | 0.0126969553517 | 0.4 | NCBP1 NCBP2 | HIV Transcription Elongation |
| REAC:R-HSA-167246 | 0.0126969553517 | 0.4 | NCBP1 NCBP2 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 0.0126969553517 | 0.4 | NCBP1 NCBP2 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| GO:0051030 | 0.0135228859698 | 0.4 | NCBP2 PHAX | snRNA transport |
| REAC:R-HSA-167152 | 0.0138877528683 | 0.4 | NCBP1 NCBP2 | Formation of HIV elongation complex in the absence of HIV Tat |
| KEGG:03015 | 0.0162467151192 | 0.4 | NCBP1 NCBP2 | mRNA surveillance pathway |
| REAC:R-HSA-72165 | 0.017778070678 | 0.4 | NCBP1 NCBP2 | mRNA Splicing - Minor Pathway |
| REAC:R-HSA-1226099 | 0.0184727645209 | 0.4 | NCBP1 NCBP2 | Signaling by FGFR in disease |
| REAC:R-HSA-72187 | 0.019180674733 | 0.4 | NCBP1 NCBP2 | mRNA 3'-end processing |
| REAC:R-HSA-5654738 | 0.0221443716613 | 0.4 | NCBP1 NCBP2 | Signaling by FGFR2 |
| REAC:R-HSA-75955 | 0.0229182830201 | 0.4 | NCBP1 NCBP2 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 0.0229182830201 | 0.4 | NCBP1 NCBP2 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-73857 | 0.0251017869848 | 0.8 | SRRT NCBP1 PHAX NCBP2 | RNA Polymerase II Transcription |
| WP:WP411 | 0.0254557044772 | 0.4 | NCBP1 NCBP2 | mRNA Processing |
| REAC:R-HSA-73856 | 0.0261457156832 | 0.4 | NCBP1 NCBP2 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-190236 | 0.0295837500362 | 0.4 | NCBP1 NCBP2 | Signaling by FGFR |
| REAC:R-HSA-159236 | 0.0304761248659 | 0.4 | NCBP1 NCBP2 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-167172 | 0.0332320424718 | 0.4 | NCBP1 NCBP2 | Transcription of the HIV genome |
| KEGG:03040 | 0.0353865382697 | 0.4 | NCBP1 NCBP2 | Spliceosome |
| REAC:R-HSA-74160 | 0.038571388232 | 0.8 | SRRT NCBP1 PHAX NCBP2 | Gene expression (Transcription) |
| REAC:R-HSA-72202 | 0.0390979640759 | 0.4 | NCBP1 NCBP2 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-674695 | 0.0443461879505 | 0.4 | NCBP1 NCBP2 | RNA Polymerase II Pre-transcription Events |
| CORUM:1190 | 0.0499494897235 | 0.2 | NCBP1 | NCBP-NIP1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SRRT | NCBP2 | 0.959 | 0.863 | hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2) |
| SRRT | NCBP1 | 0.4 | 0.56 | hein_WMM bioplex_WMM youn_WMM hein (NCBP1) gupta_WMM treiber_WMM |
| NCBP2 | PHAX | 0.093 | 0.355 | hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2) |
| NCBP2 | NCBP1 | 0.048 | 0.293 | hein_WMM youn (NCBP2) bioplex_WMM Guru youn_WMM hein (NCBP1,NCBP2) fraction |
| NCBP1 | PHAX | 0.026 | 0.22 | hein_WMM bioplex_WMM youn_WMM hein (NCBP1,PHAX) gupta_WMM |
| NCBP2 | LENG1 | 0.023 | 0.208 | hein_WMM hein (NCBP2) |
| LENG1 | PHAX | 0.007 | 0.003 | hein_WMM youn_WMM WMM_only |
| SRRT | LENG1 | 0.007 | 0.001 | hein_WMM gupta_WMM WMM_only |
| NCBP1 | LENG1 | 0.007 | 0.004 | hein_WMM youn_WMM WMM_only |
| SRRT | PHAX | 0.0 | 0.01 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_06277 has an average edge precision of 0.252 which is ranked 5353 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NCBP1 | HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06277 |
| NCBP2 | HuMAP2_00359 HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06262 HuMAP2_06277 HuMAP2_06561 |
| SRRT | HuMAP2_00054 HuMAP2_00359 HuMAP2_06277 HuMAP2_06561 |
| PHAX | HuMAP2_00427 HuMAP2_06019 HuMAP2_06277 |
| LENG1 | HuMAP2_00427 HuMAP2_06019 HuMAP2_06277 |