hu.MAP 2.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Links
TRIB1	Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)	UniProt NCBI
COP1	E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)	UniProt NCBI
STK40	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495)	UniProt NCBI
FAM120B	Constitutive coactivator of peroxisome proliferator-activated receptor gamma (Constitutive coactivator of PPAR-gamma) (Constitutive coactivator of PPARG) (PPARG constitutive coactivator 1) (PGCC1) (Protein FAM120B)	UniProt NCBI
MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase)	UniProt NCBI
TRIB2	Tribbles homolog 2 (TRB-2)	UniProt NCBI
ETV5	ETS translocation variant 5 (Ets-related protein ERM)	UniProt NCBI
FOS	Proto-oncogene c-Fos (Cellular oncogene fos) (G0/G1 switch regulatory protein 7)	UniProt NCBI
ETV1	ETS translocation variant 1 (Ets-related protein 81)	UniProt NCBI
DET1	DET1 homolog (De-etiolated-1 homolog)	UniProt NCBI
ETS2	Protein C-ets-2	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2695	0.000100616904936	0.181818181818	FOS ETS2	ETS2-FOS-JUN complex
CORUM:1214	0.000335119479973	0.181818181818	COP1 DET1	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
GO:0032436	0.00566826623047	0.363636363636	COP1 DET1 TRIB2 TRIB1	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000060	0.0100522626862	0.363636363636	COP1 DET1 TRIB2 TRIB1	positive regulation of ubiquitin-dependent protein catabolic process
GO:1901800	0.0130110345685	0.363636363636	COP1 DET1 TRIB2 TRIB1	positive regulation of proteasomal protein catabolic process
GO:1903052	0.0227301816191	0.363636363636	COP1 DET1 TRIB2 TRIB1	positive regulation of proteolysis involved in cellular protein catabolic process
GO:0032434	0.0258322357025	0.363636363636	COP1 DET1 TRIB2 TRIB1	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045862	0.0337086388398	0.454545454545	COP1 TRIB1 DET1 TRIB2 MALT1	positive regulation of proteolysis
WP:WP3863	0.04031440183	0.181818181818	MALT1 FOS	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
GO:1903364	0.0463086383902	0.363636363636	COP1 DET1 TRIB2 TRIB1	positive regulation of cellular protein catabolic process
KEGG:04662	0.0481126379603	0.181818181818	MALT1 FOS	B cell receptor signaling pathway
CORUM:2051	0.0499697183507	0.0909090909091	MALT1	MALT1 homo-oligomer complex
CORUM:2790	0.0499697183507	0.0909090909091	ETS2	ETS2-ETS1 complex

Protein 1	Protein 2	Score	Precision	Evidence
TRIB1	STK40	0.29	0.492	bioplex (STK40,TRIB1) bioplex_WMM
COP1	ETV5	0.223	0.467	bioplex (ETV5) bioplex_WMM
DET1	TRIB2	0.178	0.436	bioplex (TRIB2) bioplex_WMM
DET1	TRIB1	0.155	0.416	bioplex (TRIB1) bioplex_WMM
FOS	COP1	0.148	0.409	hein_WMM bioplex (FOS) bioplex_WMM hein (FOS)
TRIB2	STK40	0.134	0.406	bioplex (TRIB2) bioplex_WMM
COP1	STK40	0.133	0.406	bioplex (COP1,STK40) bioplex_WMM
DET1	ETV5	0.114	0.384	bioplex (ETV5) bioplex_WMM
COP1	DET1	0.097	0.358	bioplex (COP1,DET1) bioplex_WMM
COP1	TRIB1	0.087	0.353	bioplex (TRIB1) bioplex_WMM
COP1	ETS2	0.075	0.356	hein_WMM hein (ETS2)
MALT1	TRIB1	0.069	0.349	bioplex (TRIB1) bioplex_WMM
COP1	TRIB2	0.065	0.347	bioplex (TRIB2) bioplex_WMM
COP1	ETV1	0.059	0.33	bioplex (ETV1) bioplex_WMM
DET1	STK40	0.052	0.301	bioplex (DET1) bioplex_WMM
FAM120B	COP1	0.046	0.292	bioplex (COP1) bioplex_WMM
ETV5	STK40	0.045	0.281	bioplex (ETV5) bioplex_WMM
FOS	DET1	0.024	0.214	bioplex (FOS) bioplex_WMM
TRIB1	TRIB2	0.016	0.156	bioplex (TRIB2) bioplex_WMM
FOS	STK40	0.01	0.139	bioplex (FOS) bioplex_WMM
DET1	MALT1	0.008	0.06	bioplex_WMM WMM_only
MALT1	STK40	0.008	0.028	bioplex_WMM WMM_only
COP1	MALT1	0.008	0.025	bioplex_WMM WMM_only
DET1	ETV1	0.008	0.028	bioplex (ETV1) bioplex_WMM
FAM120B	DET1	0.007	0.004	bioplex_WMM WMM_only
FAM120B	STK40	0.007	0.003	bioplex_WMM WMM_only
STK40	ETV1	0.004	0.008	bioplex (ETV1) bioplex_WMM

Click to enlarge

Complex HuMAP2_06278 has an average edge precision of 0.261 which is ranked 5209 out of all 6965 complexes.