hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06279
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| B2M | Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3] | UniProt NCBI |
| FGFR4 | Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) | UniProt NCBI |
| FCGRT | IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) | UniProt NCBI |
| PODXL2 | Podocalyxin-like protein 2 (Endoglycan) | UniProt NCBI |
| PRTG | Protogenin (Protein Shen-Dan) | UniProt NCBI |
| CD1B | T-cell surface glycoprotein CD1b (CD antigen CD1b) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0019883 | 0.000824951429902 | 0.5 | FCGRT CD1B B2M | antigen processing and presentation of endogenous antigen |
| GO:0002711 | 0.0108183376095 | 0.5 | FCGRT CD1B B2M | positive regulation of T cell mediated immunity |
| CORUM:6833 | 0.0249904952816 | 0.166666666667 | FGFR4 | FGFR4-KLB complex |
| CORUM:6835 | 0.0249904952816 | 0.166666666667 | FGFR4 | FGF21-FGFR4-KLB complex |
| CORUM:6837 | 0.0249904952816 | 0.166666666667 | FGFR4 | FGFR4-KLB complex |
| GO:0002709 | 0.0292571070793 | 0.5 | FCGRT CD1B B2M | regulation of T cell mediated immunity |
| GO:0002824 | 0.0312028564126 | 0.5 | FCGRT CD1B B2M | positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| GO:0002708 | 0.0332327932613 | 0.5 | FCGRT CD1B B2M | positive regulation of lymphocyte mediated immunity |
| GO:0002821 | 0.0422297014162 | 0.5 | FCGRT CD1B B2M | positive regulation of adaptive immune response |
| CORUM:6832 | 0.0499726005494 | 0.166666666667 | FGFR4 | FGF19-FGFR4-KLB complex, heparin induced |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CD1B | B2M | 0.424 | 0.574 | bioplex (CD1B) bioplex_WMM |
| CD1B | FCGRT | 0.114 | 0.383 | bioplex (CD1B) bioplex_WMM |
| FCGRT | B2M | 0.077 | 0.352 | bioplex (B2M,FCGRT) bioplex_WMM |
| CD1B | PODXL2 | 0.056 | 0.315 | bioplex (CD1B) bioplex_WMM |
| FCGRT | FGFR4 | 0.046 | 0.292 | bioplex (FCGRT) bioplex_WMM |
| PODXL2 | FCGRT | 0.044 | 0.279 | bioplex (FCGRT) bioplex_WMM |
| FCGRT | PRTG | 0.042 | 0.269 | bioplex (FCGRT) bioplex_WMM |
| PRTG | FGFR4 | 0.009 | 0.105 | bioplex_WMM WMM_only |
| PODXL2 | PRTG | 0.009 | 0.1 | bioplex_WMM WMM_only |
| PODXL2 | FGFR4 | 0.008 | 0.08 | bioplex_WMM WMM_only |
| PRTG | B2M | 0.007 | 0.007 | bioplex_WMM WMM_only |
| PODXL2 | B2M | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| FGFR4 | B2M | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06279 has an average edge precision of 0.212 which is ranked 5986 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| B2M | HuMAP2_02832 HuMAP2_03559 HuMAP2_04339 HuMAP2_04704 HuMAP2_05520 HuMAP2_06279 |
| FGFR4 | HuMAP2_01505 HuMAP2_06279 |
| FCGRT | HuMAP2_01127 HuMAP2_06279 |
| PODXL2 | HuMAP2_00068 HuMAP2_03743 HuMAP2_06279 |
| PRTG | HuMAP2_01127 HuMAP2_02142 HuMAP2_04746 HuMAP2_06279 |
| CD1B | HuMAP2_00068 HuMAP2_05520 HuMAP2_06279 |