hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06280
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SART3 | Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein) | UniProt NCBI |
| PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) | UniProt NCBI |
| TUT1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | UniProt NCBI |
| PRPF4 | U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) | UniProt NCBI |
| SNU13 | NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097525 | 2.05203849429e-07 | 0.833333333333 | PRPF4 LSM4 SART3 SNU13 PRPF3 | spliceosomal snRNP complex |
| GO:0030532 | 3.4435733921e-07 | 0.833333333333 | PRPF4 LSM4 SART3 SNU13 PRPF3 | small nuclear ribonucleoprotein complex |
| GO:0120114 | 7.88713252093e-07 | 0.833333333333 | PRPF4 LSM4 SART3 SNU13 PRPF3 | Sm-like protein family complex |
| KEGG:03040 | 3.79677162219e-06 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | Spliceosome |
| CORUM:351 | 6.85849890916e-06 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | Spliceosome |
| GO:0046540 | 1.00004074113e-05 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 1.00004074113e-05 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | spliceosomal tri-snRNP complex |
| GO:0006397 | 1.75466405335e-05 | 1.0 | SART3 PRPF3 TUT1 SNU13 PRPF4 LSM4 | mRNA processing |
| GO:0017069 | 2.40824494048e-05 | 0.666666666667 | PRPF4 LSM4 SART3 SNU13 | snRNA binding |
| GO:0030621 | 3.63109651748e-05 | 0.5 | PRPF4 SART3 SNU13 | U4 snRNA binding |
| REAC:R-HSA-72163 | 4.76078002862e-05 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 5.67951064007e-05 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | mRNA Splicing |
| GO:0071005 | 8.38584297733e-05 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | U2-type precatalytic spliceosome |
| GO:0071011 | 9.09855163313e-05 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | precatalytic spliceosome |
| REAC:R-HSA-72203 | 0.000144935124655 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0017070 | 0.000299339163023 | 0.5 | PRPF4 SART3 LSM4 | U6 snRNA binding |
| WP:WP411 | 0.000468249477071 | 0.5 | PRPF4 SNU13 PRPF3 | mRNA Processing |
| GO:0016071 | 0.000589815677807 | 1.0 | SART3 PRPF3 TUT1 SNU13 PRPF4 LSM4 | mRNA metabolic process |
| GO:0006396 | 0.000951885417861 | 1.0 | SART3 PRPF3 TUT1 SNU13 PRPF4 LSM4 | RNA processing |
| GO:0005684 | 0.000968898210955 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | U2-type spliceosomal complex |
| GO:0000398 | 0.00115243061952 | 0.833333333333 | PRPF4 LSM4 SART3 SNU13 PRPF3 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.00115243061952 | 0.833333333333 | PRPF4 LSM4 SART3 SNU13 PRPF3 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00120907776661 | 0.833333333333 | PRPF4 LSM4 SART3 SNU13 PRPF3 | RNA splicing, via transesterification reactions |
| GO:0008380 | 0.00270779091032 | 0.833333333333 | PRPF4 LSM4 SART3 SNU13 PRPF3 | RNA splicing |
| REAC:R-HSA-8953854 | 0.00833913786065 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | Metabolism of RNA |
| GO:0005681 | 0.00970139563937 | 0.666666666667 | PRPF4 LSM4 SNU13 PRPF3 | spliceosomal complex |
| GO:0015030 | 0.0140408309691 | 0.5 | PRPF4 SART3 PRPF3 | Cajal body |
| GO:0000387 | 0.0152420239566 | 0.5 | PRPF3 SART3 LSM4 | spliceosomal snRNP assembly |
| GO:0071001 | 0.020283420769 | 0.333333333333 | PRPF4 SART3 | U4/U6 snRNP |
| GO:0003723 | 0.0386338629612 | 1.0 | SART3 PRPF3 TUT1 SNU13 PRPF4 LSM4 | RNA binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRPF4 | PRPF3 | 1.0 | 0.949 | hein_WMM bioplex (PRPF3,PRPF4) bioplex_WMM Guru boldt youn_WMM hein (PRPF3,PRPF4) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SART3 | PRPF3 | 1.0 | 0.949 | hein_WMM bioplex (PRPF3,SART3) bioplex_WMM boldt youn_WMM hein (PRPF3,SART3) gupta_WMM fraction boldt_WMM |
| SART3 | PRPF4 | 1.0 | 0.949 | hein_WMM bioplex (PRPF4,SART3) bioplex_WMM boldt youn_WMM hein (PRPF4,SART3) gupta_WMM boldt_WMM treiber_WMM |
| SART3 | TUT1 | 0.998 | 0.944 | hein_WMM bioplex (SART3) bioplex_WMM hein (SART3) gupta_WMM |
| PRPF3 | TUT1 | 0.994 | 0.921 | hein_WMM bioplex (PRPF3) bioplex_WMM hein (PRPF3) |
| PRPF3 | SNU13 | 0.929 | 0.845 | hein_WMM bioplex (PRPF3) bioplex_WMM youn_WMM hein (PRPF3) gupta_WMM fraction boldt_WMM |
| PRPF3 | LSM4 | 0.912 | 0.835 | youn (LSM4) bioplex (PRPF3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PRPF4 | TUT1 | 0.892 | 0.819 | hein_WMM bioplex (PRPF4) bioplex_WMM hein (PRPF4) |
| SART3 | LSM4 | 0.839 | 0.784 | youn (LSM4) bioplex (SART3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PRPF4 | LSM4 | 0.763 | 0.748 | youn (LSM4) bioplex (PRPF4) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PRPF4 | SNU13 | 0.513 | 0.632 | hein_WMM bioplex (PRPF4) bioplex_WMM youn_WMM hein (PRPF4) gupta_WMM fraction boldt_WMM |
| SART3 | SNU13 | 0.032 | 0.246 | hein_WMM bioplex (SART3) bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| LSM4 | TUT1 | 0.026 | 0.216 | bioplex_WMM gupta_WMM WMM_only |
| TUT1 | SNU13 | 0.018 | 0.177 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| LSM4 | SNU13 | 0.01 | 0.106 | youn (LSM4) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_06280 has an average edge precision of 0.675 which is ranked 1483 out of all 6965 complexes.
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