hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06289
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERLEC1 | Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) (XTP3-transactivated gene B protein) | UniProt NCBI |
| SEL1L | Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) | UniProt NCBI |
| JAM3 | Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)] | UniProt NCBI |
| OS9 | Protein OS-9 (Amplified in osteosarcoma 9) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6859 | 1.9301881504e-07 | 0.75 | OS9 ERLEC1 SEL1L | HRD1 complex |
| REAC:R-HSA-5362768 | 3.53365824659e-05 | 0.75 | OS9 ERLEC1 SEL1L | Hh mutants that don't undergo autocatalytic processing are degraded by ERAD |
| REAC:R-HSA-5387390 | 3.94070508018e-05 | 0.75 | OS9 ERLEC1 SEL1L | Hh mutants abrogate ligand secretion |
| REAC:R-HSA-5678895 | 4.60801423694e-05 | 0.75 | OS9 ERLEC1 SEL1L | Defective CFTR causes cystic fibrosis |
| CORUM:6886 | 5.02641999304e-05 | 0.5 | SEL1L OS9 | AUP1-OS9-SEL1L-UBC6e-UBXD8 complex |
| REAC:R-HSA-5358346 | 5.0922703922e-05 | 0.75 | OS9 ERLEC1 SEL1L | Hedgehog ligand biogenesis |
| REAC:R-HSA-5619084 | 9.45884271068e-05 | 0.75 | OS9 ERLEC1 SEL1L | ABC transporter disorders |
| KEGG:04141 | 0.000168936671102 | 0.75 | OS9 ERLEC1 SEL1L | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-382556 | 0.000210794457716 | 0.75 | OS9 ERLEC1 SEL1L | ABC-family proteins mediated transport |
| REAC:R-HSA-5358351 | 0.000626491969508 | 0.75 | OS9 ERLEC1 SEL1L | Signaling by Hedgehog |
| REAC:R-HSA-5619115 | 0.000831665207328 | 0.75 | OS9 ERLEC1 SEL1L | Disorders of transmembrane transporters |
| GO:0030970 | 0.00106129291317 | 0.75 | OS9 ERLEC1 SEL1L | retrograde protein transport, ER to cytosol |
| GO:1903513 | 0.00106129291317 | 0.75 | OS9 ERLEC1 SEL1L | endoplasmic reticulum to cytosol transport |
| REAC:R-HSA-901032 | 0.00210807296175 | 0.5 | SEL1L OS9 | ER Quality Control Compartment (ERQC) |
| REAC:R-HSA-901042 | 0.00326103241616 | 0.5 | SEL1L OS9 | Calnexin/calreticulin cycle |
| GO:0032527 | 0.00358246159338 | 0.75 | OS9 ERLEC1 SEL1L | protein exit from endoplasmic reticulum |
| REAC:R-HSA-532668 | 0.00596538345738 | 0.5 | SEL1L OS9 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| REAC:R-HSA-5663202 | 0.00839415877685 | 0.75 | OS9 ERLEC1 SEL1L | Diseases of signal transduction |
| GO:0030433 | 0.0225145500348 | 0.75 | OS9 ERLEC1 SEL1L | ubiquitin-dependent ERAD pathway |
| REAC:R-HSA-382551 | 0.047385920536 | 0.75 | OS9 ERLEC1 SEL1L | Transport of small molecules |
| GO:0036503 | 0.0484715579516 | 0.75 | OS9 ERLEC1 SEL1L | ERAD pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERLEC1 | SEL1L | 1.0 | 0.949 | hein_WMM bioplex (ERLEC1) hein (SEL1L) gupta_WMM boldt_WMM bioplex_WMM |
| SEL1L | OS9 | 1.0 | 0.949 | hein_WMM bioplex (OS9) hein (SEL1L) gupta_WMM boldt_WMM bioplex_WMM |
| ERLEC1 | JAM3 | 0.044 | 0.278 | bioplex (ERLEC1) bioplex_WMM fraction |
| OS9 | JAM3 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| SEL1L | JAM3 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| ERLEC1 | OS9 | 0.0 | 0.006 | hein_WMM bioplex (ERLEC1,OS9) bioplex_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_06289 has an average edge precision of 0.364 which is ranked 3695 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ERLEC1 | HuMAP2_00816 HuMAP2_01997 HuMAP2_06289 HuMAP2_06933 |
| SEL1L | HuMAP2_00816 HuMAP2_01997 HuMAP2_06289 HuMAP2_06933 |
| JAM3 | HuMAP2_02142 HuMAP2_06289 HuMAP2_06534 HuMAP2_06933 |
| OS9 | HuMAP2_00960 HuMAP2_01924 HuMAP2_01997 HuMAP2_03097 HuMAP2_06289 HuMAP2_06933 |