hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06300
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SYT1 | Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) | UniProt NCBI |
| SYT2 | Synaptotagmin-2 (Synaptotagmin II) (SytII) | UniProt NCBI |
| SYT5 | Synaptotagmin-5 (Synaptotagmin V) (SytV) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031045 | 1.81637152046e-06 | 1.0 | SYT5 SYT2 SYT1 | dense core granule |
| GO:0048791 | 1.49850650438e-05 | 1.0 | SYT5 SYT2 SYT1 | calcium ion-regulated exocytosis of neurotransmitter |
| REAC:R-HSA-5250958 | 2.00852924023e-05 | 0.666666666667 | SYT2 SYT1 | Toxicity of botulinum toxin type B (BoNT/B) |
| GO:0014059 | 0.000103533176666 | 1.0 | SYT5 SYT2 SYT1 | regulation of dopamine secretion |
| GO:0014046 | 0.000103533176666 | 1.0 | SYT5 SYT2 SYT1 | dopamine secretion |
| REAC:R-HSA-168799 | 0.000240958766872 | 0.666666666667 | SYT2 SYT1 | Neurotoxicity of clostridium toxins |
| GO:0050432 | 0.000265644334868 | 1.0 | SYT5 SYT2 SYT1 | catecholamine secretion |
| GO:0015872 | 0.000265644334868 | 1.0 | SYT5 SYT2 SYT1 | dopamine transport |
| GO:0050433 | 0.000265644334868 | 1.0 | SYT5 SYT2 SYT1 | regulation of catecholamine secretion |
| GO:0017158 | 0.000265644334868 | 1.0 | SYT5 SYT2 SYT1 | regulation of calcium ion-dependent exocytosis |
| GO:0051937 | 0.000594407580071 | 1.0 | SYT5 SYT2 SYT1 | catecholamine transport |
| GO:0048488 | 0.000594407580071 | 1.0 | SYT5 SYT2 SYT1 | synaptic vesicle endocytosis |
| GO:0140238 | 0.000594407580071 | 1.0 | SYT5 SYT2 SYT1 | presynaptic endocytosis |
| GO:0051952 | 0.000766145507331 | 1.0 | SYT5 SYT2 SYT1 | regulation of amine transport |
| GO:0001786 | 0.000897287531108 | 1.0 | SYT5 SYT2 SYT1 | phosphatidylserine binding |
| GO:0017156 | 0.000897287531108 | 1.0 | SYT5 SYT2 SYT1 | calcium-ion regulated exocytosis |
| GO:0030276 | 0.000968126020406 | 1.0 | SYT5 SYT2 SYT1 | clathrin binding |
| GO:0015837 | 0.00104259725275 | 1.0 | SYT5 SYT2 SYT1 | amine transport |
| GO:0005544 | 0.0011207920467 | 1.0 | SYT5 SYT2 SYT1 | calcium-dependent phospholipid binding |
| GO:0036465 | 0.0011207920467 | 1.0 | SYT5 SYT2 SYT1 | synaptic vesicle recycling |
| GO:0015844 | 0.00120280122085 | 1.0 | SYT5 SYT2 SYT1 | monoamine transport |
| REAC:R-HSA-5339562 | 0.00140483748394 | 0.666666666667 | SYT2 SYT1 | Uptake and actions of bacterial toxins |
| GO:0099501 | 0.00178004409005 | 1.0 | SYT5 SYT2 SYT1 | exocytic vesicle membrane |
| GO:0030672 | 0.00178004409005 | 1.0 | SYT5 SYT2 SYT1 | synaptic vesicle membrane |
| GO:0016079 | 0.00212751596192 | 1.0 | SYT5 SYT2 SYT1 | synaptic vesicle exocytosis |
| GO:2001023 | 0.00212751596192 | 1.0 | SYT5 SYT2 SYT1 | regulation of response to drug |
| GO:0019905 | 0.00225266395968 | 1.0 | SYT5 SYT2 SYT1 | syntaxin binding |
| GO:0015696 | 0.00238262534197 | 1.0 | SYT5 SYT2 SYT1 | ammonium transport |
| GO:0072341 | 0.00280229798177 | 1.0 | SYT5 SYT2 SYT1 | modified amino acid binding |
| GO:0071277 | 0.00295242108794 | 1.0 | SYT5 SYT2 SYT1 | cellular response to calcium ion |
| GO:1903305 | 0.00564855215433 | 1.0 | SYT5 SYT2 SYT1 | regulation of regulated secretory pathway |
| REAC:R-HSA-6794361 | 0.00920519282533 | 0.666666666667 | SYT2 SYT1 | Neurexins and neuroligins |
| GO:0000149 | 0.0103137207675 | 1.0 | SYT5 SYT2 SYT1 | SNARE binding |
| GO:0051592 | 0.0110330947082 | 1.0 | SYT5 SYT2 SYT1 | response to calcium ion |
| GO:0099643 | 0.0117851633362 | 1.0 | SYT5 SYT2 SYT1 | signal release from synapse |
| GO:0007269 | 0.0117851633362 | 1.0 | SYT5 SYT2 SYT1 | neurotransmitter secretion |
| GO:0099504 | 0.0129761581422 | 1.0 | SYT5 SYT2 SYT1 | synaptic vesicle cycle |
| GO:0099003 | 0.0133902908488 | 1.0 | SYT5 SYT2 SYT1 | vesicle-mediated transport in synapse |
| HP:0010535 | 0.0150860897283 | 0.666666666667 | SYT2 SYT1 | Sleep apnea |
| GO:0071248 | 0.0155935495032 | 1.0 | SYT5 SYT2 SYT1 | cellular response to metal ion |
| GO:0015893 | 0.0160613559883 | 1.0 | SYT5 SYT2 SYT1 | drug transport |
| GO:0030658 | 0.0175207196864 | 1.0 | SYT5 SYT2 SYT1 | transport vesicle membrane |
| GO:0008021 | 0.0185411572066 | 1.0 | SYT5 SYT2 SYT1 | synaptic vesicle |
| REAC:R-HSA-6794362 | 0.0216163677069 | 0.666666666667 | SYT2 SYT1 | Protein-protein interactions at synapses |
| GO:0071241 | 0.0248678516681 | 1.0 | SYT5 SYT2 SYT1 | cellular response to inorganic substance |
| REAC:R-HSA-8856825 | 0.0261170593829 | 0.666666666667 | SYT2 SYT1 | Cargo recognition for clathrin-mediated endocytosis |
| GO:0070382 | 0.0281650200706 | 1.0 | SYT5 SYT2 SYT1 | exocytic vesicle |
| GO:0017157 | 0.0302766427817 | 1.0 | SYT5 SYT2 SYT1 | regulation of exocytosis |
| GO:0015850 | 0.0442598881134 | 1.0 | SYT5 SYT2 SYT1 | organic hydroxy compound transport |
| GO:0006836 | 0.0451949561721 | 1.0 | SYT5 SYT2 SYT1 | neurotransmitter transport |
| MIRNA:hsa-miR-8485 | 0.0463323463302 | 1.0 | SYT5 SYT2 SYT1 | hsa-miR-8485 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SYT2 | SYT1 | 0.999 | 0.949 | bioplex (SYT1) bioplex_WMM boldt_WMM |
| SYT1 | SYT5 | 0.977 | 0.893 | bioplex (SYT1,SYT5) bioplex_WMM |
| SYT2 | SYT5 | 0.008 | 0.095 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06300 has an average edge precision of 0.646 which is ranked 1669 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SYT1 | HuMAP2_06300 HuMAP2_06794 |
| SYT2 | HuMAP2_06300 HuMAP2_06794 |
| SYT5 | HuMAP2_06300 HuMAP2_06794 |