hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06316
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CRYAB | Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component) | UniProt NCBI |
| HSPB1 | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0002600 | 0.000921683418819 | 1.0 | CRYAB HSPB1 | Hyporeflexia of lower limbs |
| HP:0009027 | 0.00571376931014 | 1.0 | CRYAB HSPB1 | Foot dorsiflexor weakness |
| HP:0002460 | 0.0315676570945 | 1.0 | CRYAB HSPB1 | Distal muscle weakness |
| HP:0003677 | 0.0334310605282 | 1.0 | CRYAB HSPB1 | Slow progression |
| HP:0003581 | 0.0393418563663 | 1.0 | CRYAB HSPB1 | Adult onset |
| HP:0030224 | 0.0497341708567 | 0.5 | CRYAB | Abnormal muscle fiber desmin |
| HP:0030225 | 0.0497341708567 | 0.5 | CRYAB | Accumulation of muscle fiber desmin |
| HP:0100017 | 0.0497341708567 | 0.5 | CRYAB | Capsular cataract |
| HP:0100020 | 0.0497341708567 | 0.5 | CRYAB | Posterior capsular cataract |
| CORUM:6096 | 0.0499173803268 | 0.5 | CRYAB | alphaB-crystallin-Nav1.5 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CRYAB | HSPB1 | 0.993 | 0.918 | bioplex (CRYAB) bioplex_WMM fraction |
Images
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Complex HuMAP2_06316 has an average edge precision of 0.918 which is ranked 482 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CRYAB | HuMAP2_02613 HuMAP2_03201 HuMAP2_05639 HuMAP2_06316 |
| HSPB1 | HuMAP2_02613 HuMAP2_05639 HuMAP2_06316 |