hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06332
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DDR1 | Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) | UniProt NCBI |
| TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | UniProt NCBI |
| RNF149 | E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149) | UniProt NCBI |
| CASP8 | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | UniProt NCBI |
| UGCG | Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-75158 | 0.000283261545489 | 0.4 | CASP8 TNFRSF10B | TRAIL signaling |
| REAC:R-HSA-5218900 | 0.000485460775426 | 0.4 | CASP8 TNFRSF10B | CASP8 activity is inhibited |
| REAC:R-HSA-69416 | 0.000485460775426 | 0.4 | CASP8 TNFRSF10B | Dimerization of procaspase-8 |
| REAC:R-HSA-3371378 | 0.000485460775426 | 0.4 | CASP8 TNFRSF10B | Regulation by c-FLIP |
| HPA:024020_23 | 0.000518323196243 | 1.0 | RNF149 DDR1 TNFRSF10B UGCG CASP8 | kidney; cells in tubules[Approved,High] |
| WP:WP3982 | 0.000769338921543 | 0.4 | CASP8 TNFRSF10B | miRNA regulation of p53 pathway in prostate cancer |
| REAC:R-HSA-140534 | 0.00105126658749 | 0.4 | CASP8 TNFRSF10B | Caspase activation via Death Receptors in the presence of ligand |
| REAC:R-HSA-5675482 | 0.00161668141155 | 0.4 | CASP8 TNFRSF10B | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.00206071490935 | 0.4 | CASP8 TNFRSF10B | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5218859 | 0.00206071490935 | 0.4 | CASP8 TNFRSF10B | Regulated Necrosis |
| REAC:R-HSA-5357769 | 0.0031096034254 | 0.4 | CASP8 TNFRSF10B | Caspase activation via extrinsic apoptotic signalling pathway |
| HPA:048010_21 | 0.00335378641122 | 1.0 | RNF149 DDR1 TNFRSF10B UGCG CASP8 | soft tissue 2; adipocytes[Approved,Low] |
| WP:WP707 | 0.00731923889784 | 0.4 | CASP8 TNFRSF10B | DNA Damage Response |
| WP:WP1530 | 0.00799132765459 | 0.4 | CASP8 TNFRSF10B | miRNA Regulation of DNA Damage Response |
| KEGG:04115 | 0.00858395707223 | 0.4 | CASP8 TNFRSF10B | p53 signaling pathway |
| WP:WP254 | 0.00869264148791 | 0.4 | CASP8 TNFRSF10B | Apoptosis |
| WP:WP1772 | 0.0107054175474 | 0.4 | CASP8 TNFRSF10B | Apoptosis Modulation and Signaling |
| HPA:002010_23 | 0.0110044792407 | 0.8 | RNF149 DDR1 TNFRSF10B CASP8 | appendix; glandular cells[Approved,High] |
| HPA:052010_23 | 0.0236977257338 | 0.8 | RNF149 DDR1 TNFRSF10B CASP8 | stomach 2; glandular cells[Approved,High] |
| CORUM:6158 | 0.0249780992026 | 0.2 | TNFRSF10B | TRIAL-DR5 complex |
| HPA:027010_22 | 0.0295329330948 | 1.0 | RNF149 DDR1 TNFRSF10B UGCG CASP8 | lung; macrophages[Approved,Medium] |
| HPA:011020_23 | 0.0303700548154 | 0.8 | RNF149 DDR1 TNFRSF10B CASP8 | colon; glandular cells[Approved,High] |
| KEGG:04210 | 0.0327287628992 | 0.4 | CASP8 TNFRSF10B | Apoptosis |
| HPA:037010_23 | 0.0374127578786 | 0.8 | RNF149 DDR1 TNFRSF10B CASP8 | rectum; glandular cells[Approved,High] |
| HPA:045010_23 | 0.044149049201 | 0.8 | RNF149 DDR1 TNFRSF10B CASP8 | small intestine; glandular cells[Approved,High] |
| KEGG:05164 | 0.0457961859483 | 0.4 | CASP8 TNFRSF10B | Influenza A |
| KEGG:04217 | 0.0482876775804 | 0.4 | CASP8 TNFRSF10B | Necroptosis |
| HPA:012010_23 | 0.0491592434223 | 0.8 | RNF149 DDR1 TNFRSF10B CASP8 | duodenum; glandular cells[Approved,High] |
| CORUM:1062 | 0.0499494897235 | 0.2 | CASP8 | BAR-BCL2-CASP8 complex |
| CORUM:5808 | 0.0499494897235 | 0.2 | CASP8 | DISC complex (CD95, FADD, CASP8) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CASP8 | TNFRSF10B | 0.268 | 0.482 | bioplex (TNFRSF10B) bioplex_WMM |
| UGCG | TNFRSF10B | 0.059 | 0.328 | bioplex (TNFRSF10B) bioplex_WMM |
| RNF149 | TNFRSF10B | 0.035 | 0.26 | bioplex (TNFRSF10B) bioplex_WMM |
| DDR1 | TNFRSF10B | 0.035 | 0.266 | bioplex (TNFRSF10B) bioplex_WMM |
| RNF149 | UGCG | 0.012 | 0.149 | bioplex_WMM WMM_only |
| DDR1 | CASP8 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| CASP8 | UGCG | 0.008 | 0.088 | bioplex_WMM WMM_only |
| DDR1 | UGCG | 0.008 | 0.081 | bioplex_WMM WMM_only |
| RNF149 | DDR1 | 0.008 | 0.032 | bioplex_WMM WMM_only |
| RNF149 | CASP8 | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06332 has an average edge precision of 0.178 which is ranked 6442 out of all 6965 complexes.
Related Complexes