hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06333
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KNTC1 | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | UniProt NCBI |
| RINT1 | RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) | UniProt NCBI |
| C19orf25 | UPF0449 protein C19orf25 | UniProt NCBI |
| ZW10 | Centromere/kinetochore protein zw10 homolog | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:705 | 1.50819606993e-05 | 0.5 | RINT1 ZW10 | SNARE complex (RINT1, ZW10, p31) |
| CORUM:7541 | 1.50819606993e-05 | 0.5 | KNTC1 ZW10 | KNTC1-ZW10-ZWILCH complex |
| GO:0070939 | 0.00811409485621 | 0.5 | RINT1 ZW10 | Dsl1/NZR complex |
| GO:1990423 | 0.00811409485621 | 0.5 | KNTC1 ZW10 | RZZ complex |
| REAC:R-HSA-141444 | 0.041754071825 | 0.5 | KNTC1 ZW10 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.041754071825 | 0.5 | KNTC1 ZW10 | Amplification of signal from the kinetochores |
| REAC:R-HSA-6811434 | 0.0454682616856 | 0.5 | RINT1 ZW10 | COPI-dependent Golgi-to-ER retrograde traffic |
| CORUM:6314 | 0.0499140284799 | 0.25 | RINT1 | MSP58-RINT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RINT1 | ZW10 | 1.0 | 0.949 | hein_WMM bioplex (RINT1) bioplex_WMM youn_WMM hein (ZW10) gupta_WMM |
| KNTC1 | ZW10 | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (ZW10) Malo fraction boldt_WMM |
| C19orf25 | ZW10 | 0.7 | 0.722 | hein_WMM bioplex_WMM hein (ZW10) gupta_WMM |
| RINT1 | C19orf25 | 0.559 | 0.65 | hein_WMM bioplex (RINT1) bioplex_WMM gupta_WMM |
| KNTC1 | RINT1 | 0.011 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| KNTC1 | C19orf25 | 0.008 | 0.034 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06333 has an average edge precision of 0.574 which is ranked 2057 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KNTC1 | HuMAP2_00483 HuMAP2_05736 HuMAP2_06258 HuMAP2_06333 |
| RINT1 | HuMAP2_00854 HuMAP2_02979 HuMAP2_06258 HuMAP2_06333 |
| C19orf25 | HuMAP2_00854 HuMAP2_02979 HuMAP2_05736 HuMAP2_06258 HuMAP2_06333 |
| ZW10 | HuMAP2_00854 HuMAP2_02979 HuMAP2_05736 HuMAP2_06258 HuMAP2_06333 |