hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06335
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKAP13 | A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) | UniProt NCBI |
| AKAP2 | A-kinase anchor protein 2 (AKAP-2) (AKAP-KL) (Protein kinase A-anchoring protein 2) (PRKA2) | UniProt NCBI |
| PRKX | cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1) | UniProt NCBI |
| PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | UniProt NCBI |
| CRYBG3 | Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-442720 | 0.000741476933235 | 0.4 | PRKAR2B PRKX | CREB1 phosphorylation through the activation of Adenylate Cyclase |
| REAC:R-HSA-111931 | 0.00206071490935 | 0.4 | PRKAR2B PRKX | PKA-mediated phosphorylation of CREB |
| REAC:R-HSA-111997 | 0.00709716303977 | 0.4 | PRKAR2B PRKX | CaM pathway |
| REAC:R-HSA-111933 | 0.00709716303977 | 0.4 | PRKAR2B PRKX | Calmodulin induced events |
| REAC:R-HSA-111996 | 0.00799559968784 | 0.4 | PRKAR2B PRKX | Ca-dependent events |
| REAC:R-HSA-1489509 | 0.00995219083388 | 0.4 | PRKAR2B PRKX | DAG and IP3 signaling |
| GO:0051018 | 0.0103850554114 | 0.6 | CRYBG3 PRKAR2B AKAP13 | protein kinase A binding |
| WP:WP35 | 0.0123508080289 | 0.4 | AKAP13 PRKAR2B | G Protein Signaling Pathways |
| REAC:R-HSA-112043 | 0.0170965985867 | 0.4 | PRKAR2B PRKX | PLC beta mediated events |
| REAC:R-HSA-112040 | 0.017778070678 | 0.4 | PRKAR2B PRKX | G-protein mediated events |
| REAC:R-HSA-438064 | 0.0351349281697 | 0.4 | PRKAR2B PRKX | Post NMDA receptor activation events |
| REAC:R-HSA-442755 | 0.0465369402216 | 0.4 | PRKAR2B PRKX | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-111885 | 0.0487798927038 | 0.4 | PRKAR2B PRKX | Opioid Signalling |
| CORUM:7129 | 0.0499494897235 | 0.2 | PRKAR2B | GSKIP-PRKAR2B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKAR2B | PRKX | 0.999 | 0.949 | bioplex (PRKAR2B) bioplex_WMM |
| PRKAR2B | AKAP13 | 0.999 | 0.949 | bioplex (PRKAR2B) bioplex_WMM gupta_WMM |
| PRKAR2B | AKAP2 | 0.947 | 0.857 | bioplex (PRKAR2B) bioplex_WMM |
| PRKAR2B | CRYBG3 | 0.761 | 0.749 | bioplex (PRKAR2B) bioplex_WMM youn_WMM gupta_WMM |
| AKAP13 | PRKX | 0.01 | 0.132 | hein_WMM bioplex_WMM WMM_only |
| CRYBG3 | AKAP13 | 0.009 | 0.107 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AKAP2 | PRKX | 0.009 | 0.107 | bioplex_WMM WMM_only |
| CRYBG3 | PRKX | 0.009 | 0.101 | bioplex_WMM WMM_only |
| AKAP13 | AKAP2 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| CRYBG3 | AKAP2 | 0.008 | 0.095 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06335 has an average edge precision of 0.414 which is ranked 3160 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKAP13 | HuMAP2_01832 HuMAP2_06335 |
| AKAP2 | HuMAP2_01832 HuMAP2_04753 HuMAP2_06335 |
| PRKX | HuMAP2_01832 HuMAP2_06335 |
| PRKAR2B | HuMAP2_01784 HuMAP2_01832 HuMAP2_04684 HuMAP2_06335 |
| CRYBG3 | HuMAP2_01832 HuMAP2_06335 |