hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06346
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FTH1 | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | UniProt NCBI |
| NCOA4 | Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1) | UniProt NCBI |
| MSRB3 | Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14) | UniProt NCBI |
| RBP4 | Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)] | UniProt NCBI |
| FTL | Ferritin light chain (Ferritin L subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4313 | 5.65516175491e-06 | 0.6 | FTH1 NCOA4 FTL | Ferroptosis |
| CORUM:6135 | 6.70868171695e-06 | 0.4 | FTH1 FTL | Ferritin complex |
| KEGG:04216 | 7.27092225631e-06 | 0.6 | FTH1 NCOA4 FTL | Ferroptosis |
| GO:0044754 | 5.0832789986e-05 | 0.6 | FTH1 NCOA4 FTL | autolysosome |
| GO:0005767 | 0.000199619769136 | 0.6 | FTH1 NCOA4 FTL | secondary lysosome |
| REAC:R-HSA-3000480 | 0.00183199274719 | 0.4 | FTH1 FTL | Scavenging by Class A Receptors |
| KEGG:04978 | 0.00441762805526 | 0.4 | FTH1 FTL | Mineral absorption |
| GO:0008043 | 0.00450823411379 | 0.4 | FTH1 FTL | intracellular ferritin complex |
| GO:0070288 | 0.00450823411379 | 0.4 | FTH1 FTL | ferritin complex |
| HP:0003281 | 0.00709565752293 | 0.4 | FTH1 FTL | Increased serum ferritin |
| HP:0040133 | 0.00792937512816 | 0.4 | FTH1 FTL | Abnormal serum ferritin |
| REAC:R-HSA-2173782 | 0.00799559968784 | 0.4 | FTH1 FTL | Binding and Uptake of Ligands by Scavenger Receptors |
| REAC:R-HSA-432722 | 0.019180674733 | 0.4 | FTH1 FTL | Golgi Associated Vesicle Biogenesis |
| REAC:R-HSA-917937 | 0.019180674733 | 0.4 | FTH1 FTL | Iron uptake and transport |
| WP:WP2884 | 0.0200904134765 | 0.4 | FTH1 FTL | NRF2 pathway |
| GO:0006880 | 0.0270421395626 | 0.4 | FTH1 FTL | intracellular sequestering of iron ion |
| REAC:R-HSA-199992 | 0.0341769281663 | 0.4 | FTH1 FTL | trans-Golgi Network Vesicle Budding |
| GO:0005776 | 0.0358473364726 | 0.6 | FTH1 NCOA4 FTL | autophagosome |
| GO:0097577 | 0.0450641792523 | 0.4 | FTH1 FTL | sequestering of iron ion |
| KEGG:04217 | 0.0482876775804 | 0.4 | FTH1 FTL | Necroptosis |
| CORUM:6821 | 0.0499494897235 | 0.2 | RBP4 | TTR-RBP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FTL | FTH1 | 0.176 | 0.435 | bioplex (FTH1) bioplex_WMM |
| NCOA4 | FTH1 | 0.132 | 0.404 | bioplex (FTH1,NCOA4) bioplex_WMM |
| MSRB3 | RBP4 | 0.059 | 0.328 | bioplex (MSRB3) bioplex_WMM |
| RBP4 | FTH1 | 0.053 | 0.301 | bioplex (FTH1) bioplex_WMM |
| NCOA4 | FTL | 0.021 | 0.185 | bioplex (NCOA4) bioplex_WMM |
| RBP4 | NCOA4 | 0.008 | 0.012 | bioplex_WMM WMM_only |
| RBP4 | FTL | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06346 has an average edge precision of 0.238 which is ranked 5560 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FTH1 | HuMAP2_02114 HuMAP2_06346 |
| NCOA4 | HuMAP2_00975 HuMAP2_02114 HuMAP2_06346 |
| MSRB3 | HuMAP2_00103 HuMAP2_02604 HuMAP2_03574 HuMAP2_04264 HuMAP2_06346 |
| RBP4 | HuMAP2_00103 HuMAP2_02604 HuMAP2_03574 HuMAP2_06346 |
| FTL | HuMAP2_00975 HuMAP2_02114 HuMAP2_06346 |