hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06352
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FARP1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2) | UniProt NCBI |
| BRD2 | Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein) | UniProt NCBI |
| BRD3 | Bromodomain-containing protein 3 (RING3-like protein) | UniProt NCBI |
| GPC3 | Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit] | UniProt NCBI |
| CAMKV | CaM kinase-like vesicle-associated protein | UniProt NCBI |
| GPC1 | Glypican-1 [Cleaved into: Secreted glypican-1] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656253 | 0.00201328766088 | 0.333333333333 | GPC3 GPC1 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 0.00201328766088 | 0.333333333333 | GPC3 GPC1 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-4420332 | 0.00377982352449 | 0.333333333333 | GPC3 GPC1 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 0.00377982352449 | 0.333333333333 | GPC3 GPC1 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-3560783 | 0.00377982352449 | 0.333333333333 | GPC3 GPC1 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-2024096 | 0.00464022545552 | 0.333333333333 | GPC3 GPC1 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.0060953046166 | 0.333333333333 | GPC3 GPC1 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.00895825109095 | 0.333333333333 | GPC3 GPC1 | HS-GAG biosynthesis |
| REAC:R-HSA-3560782 | 0.0163206320028 | 0.333333333333 | GPC3 GPC1 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.0180541440856 | 0.333333333333 | GPC3 GPC1 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.0208171179433 | 0.333333333333 | GPC3 GPC1 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 0.0237750563765 | 0.333333333333 | GPC3 GPC1 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 0.0269276420577 | 0.333333333333 | GPC3 GPC1 | Heparan sulfate/heparin (HS-GAG) metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BRD3 | BRD2 | 0.102 | 0.365 | bioplex (BRD3) bioplex_WMM youn_WMM fraction |
| CAMKV | GPC1 | 0.065 | 0.347 | bioplex (CAMKV) bioplex_WMM |
| BRD2 | CAMKV | 0.052 | 0.301 | bioplex (CAMKV) bioplex_WMM |
| FARP1 | BRD2 | 0.051 | 0.296 | hein_WMM hein (BRD2) |
| CAMKV | GPC3 | 0.048 | 0.294 | bioplex (CAMKV) bioplex_WMM |
| BRD3 | CAMKV | 0.045 | 0.285 | bioplex (CAMKV) bioplex_WMM |
| GPC1 | GPC3 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| BRD3 | GPC1 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| BRD2 | GPC1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| FARP1 | CAMKV | 0.007 | 0.01 | bioplex_WMM WMM_only |
| BRD3 | GPC3 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| BRD2 | GPC3 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| BRD3 | FARP1 | 0.007 | 0.001 | youn_WMM WMM_only |
Images
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Complex HuMAP2_06352 has an average edge precision of 0.159 which is ranked 6640 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FARP1 | HuMAP2_00705 HuMAP2_02548 HuMAP2_05049 HuMAP2_06352 HuMAP2_06940 |
| BRD2 | HuMAP2_01344 HuMAP2_02548 HuMAP2_02605 HuMAP2_06352 |
| BRD3 | HuMAP2_00321 HuMAP2_02548 HuMAP2_02605 HuMAP2_06352 |
| GPC3 | HuMAP2_02605 HuMAP2_04691 HuMAP2_04797 HuMAP2_06352 |
| CAMKV | HuMAP2_02605 HuMAP2_06352 |
| GPC1 | HuMAP2_02605 HuMAP2_04691 HuMAP2_04797 HuMAP2_06352 |