hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06358
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAB11FIP5 | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | UniProt NCBI |
| RAB11FIP1 | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | UniProt NCBI |
| RAB11B | Ras-related protein Rab-11B (GTP-binding protein YPT3) | UniProt NCBI |
| RAB25 | Ras-related protein Rab-25 (CATX-8) | UniProt NCBI |
| RAB11FIP2 | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | UniProt NCBI |
| SH3BP5 | SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK) | UniProt NCBI |
| RAB11A | Ras-related protein Rab-11A (Rab-11) (YL8) | UniProt NCBI |
| EVI5L | EVI5-like protein (Ecotropic viral integration site 5-like protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04144 | 2.22800019395e-06 | 0.625 | RAB11B RAB11A RAB11FIP1 RAB11FIP5 RAB11FIP2 | Endocytosis |
| CORUM:3941 | 1.16880143691e-05 | 0.25 | RAB11A RAB11FIP1 | RAB11FIP1-RAB11A complex |
| CORUM:6253 | 3.50546248845e-05 | 0.25 | RAB11FIP2 RAB11A | myosin-Vb-Rab11-FIP2-Rab11a complex |
| GO:0017137 | 0.000173874805144 | 0.625 | EVI5L RAB11FIP5 RAB11FIP1 SH3BP5 RAB11FIP2 | Rab GTPase binding |
| REAC:R-HSA-8873719 | 0.000672008352303 | 0.375 | RAB11B RAB25 RAB11A | RAB geranylgeranylation |
| GO:0031489 | 0.00184612317041 | 0.375 | RAB11B RAB25 RAB11A | myosin V binding |
| GO:0017016 | 0.00734243881803 | 0.625 | EVI5L RAB11FIP5 RAB11FIP1 SH3BP5 RAB11FIP2 | Ras GTPase binding |
| KEGG:04962 | 0.00937110970436 | 0.25 | RAB11B RAB11A | Vasopressin-regulated water reabsorption |
| GO:0031267 | 0.00974320340058 | 0.625 | EVI5L RAB11FIP5 RAB11FIP1 SH3BP5 RAB11FIP2 | small GTPase binding |
| GO:0055037 | 0.0132283912231 | 0.5 | RAB11B RAB25 RAB11FIP5 RAB11A | recycling endosome |
| GO:0006887 | 0.0142136220155 | 0.75 | RAB11FIP5 RAB25 RAB11A RAB11FIP2 RAB11B RAB11FIP1 | exocytosis |
| GO:0015031 | 0.015872461676 | 0.875 | EVI5L RAB25 RAB11FIP5 RAB11A RAB11FIP2 RAB11B RAB11FIP1 | protein transport |
| GO:0035773 | 0.0165565880345 | 0.375 | RAB11B RAB11FIP5 RAB11FIP2 | insulin secretion involved in cellular response to glucose stimulus |
| GO:0015833 | 0.017521243769 | 0.875 | EVI5L RAB25 RAB11FIP5 RAB11A RAB11FIP2 RAB11B RAB11FIP1 | peptide transport |
| GO:0042886 | 0.019118228808 | 0.875 | EVI5L RAB25 RAB11FIP5 RAB11A RAB11FIP2 RAB11B RAB11FIP1 | amide transport |
| GO:0045184 | 0.0269411801123 | 0.875 | EVI5L RAB25 RAB11FIP5 RAB11A RAB11FIP2 RAB11B RAB11FIP1 | establishment of protein localization |
| REAC:R-HSA-432040 | 0.0295328318157 | 0.25 | RAB11FIP2 RAB11A | Vasopressin regulates renal water homeostasis via Aquaporins |
| GO:0051020 | 0.0322988703623 | 0.625 | EVI5L RAB11FIP5 RAB11FIP1 SH3BP5 RAB11FIP2 | GTPase binding |
| REAC:R-HSA-445717 | 0.0328409413955 | 0.25 | RAB11FIP2 RAB11A | Aquaporin-mediated transport |
| GO:0046879 | 0.0372545640049 | 0.5 | RAB11B RAB11FIP1 RAB11FIP5 RAB11FIP2 | hormone secretion |
| GO:0070164 | 0.0378589948753 | 0.25 | RAB11FIP1 RAB11FIP5 | negative regulation of adiponectin secretion |
| REAC:R-HSA-8854214 | 0.039977733682 | 0.25 | RAB11B RAB11A | TBC/RABGAPs |
| GO:0009914 | 0.0412841915155 | 0.5 | RAB11B RAB11FIP1 RAB11FIP5 RAB11FIP2 | hormone transport |
| GO:0071705 | 0.046040830139 | 0.875 | EVI5L RAB25 RAB11FIP5 RAB11A RAB11FIP2 RAB11B RAB11FIP1 | nitrogen compound transport |
| CORUM:6561 | 0.0497224828424 | 0.125 | RAB11A | RAB11A-SPG33 complex |
| CORUM:6562 | 0.0497224828424 | 0.125 | RAB11B | RAB11B-SPG33 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB11B | RAB11FIP2 | 1.0 | 0.949 | hein_WMM bioplex (RAB11B) bioplex_WMM gupta_WMM |
| RAB11FIP2 | RAB11A | 1.0 | 0.949 | hein_WMM bioplex (RAB11A) bioplex_WMM hein (RAB11A) |
| RAB11B | RAB11FIP5 | 0.998 | 0.936 | hein_WMM bioplex (RAB11B) bioplex_WMM gupta_WMM |
| RAB11FIP1 | RAB11A | 0.985 | 0.899 | hein_WMM bioplex (RAB11A) bioplex_WMM youn_WMM hein (RAB11A) |
| RAB11A | RAB11FIP5 | 0.958 | 0.863 | hein_WMM bioplex (RAB11A) bioplex_WMM youn_WMM hein (RAB11A) |
| RAB11FIP1 | RAB11B | 0.842 | 0.786 | hein_WMM bioplex (RAB11B,RAB11FIP1) bioplex_WMM hein (RAB11FIP1) gupta_WMM |
| RAB25 | RAB11A | 0.807 | 0.767 | bioplex (RAB11A) bioplex_WMM treiber_WMM |
| RAB11B | RAB25 | 0.703 | 0.723 | bioplex (RAB11B) bioplex_WMM |
| RAB11B | SH3BP5 | 0.4 | 0.56 | bioplex (RAB11B) bioplex_WMM |
| SH3BP5 | RAB11A | 0.115 | 0.384 | bioplex (RAB11A) bioplex_WMM |
| RAB11B | RAB11A | 0.106 | 0.373 | hein_WMM hein (RAB11A) |
| RAB11A | EVI5L | 0.032 | 0.246 | hein_WMM hein (RAB11A) |
| RAB11FIP2 | SH3BP5 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| RAB25 | RAB11FIP2 | 0.011 | 0.14 | bioplex_WMM WMM_only |
| RAB25 | SH3BP5 | 0.011 | 0.14 | bioplex_WMM WMM_only |
| RAB11FIP1 | RAB11FIP2 | 0.011 | 0.142 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM |
| RAB11FIP1 | SH3BP5 | 0.01 | 0.142 | bioplex_WMM WMM_only |
| RAB11FIP2 | RAB11FIP5 | 0.01 | 0.139 | hein_WMM bioplex_WMM gupta_WMM WMM_only boldt_WMM |
| SH3BP5 | RAB11FIP5 | 0.01 | 0.129 | bioplex_WMM WMM_only |
| RAB11FIP1 | RAB25 | 0.01 | 0.118 | bioplex_WMM WMM_only |
| RAB11FIP1 | RAB11FIP5 | 0.01 | 0.116 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| RAB25 | RAB11FIP5 | 0.01 | 0.097 | bioplex_WMM WMM_only |
| RAB11B | EVI5L | 0.007 | 0.005 | hein_WMM WMM_only bioplex_WMM |
| RAB11FIP5 | EVI5L | 0.007 | 0.001 | hein_WMM WMM_only |
| RAB11FIP1 | EVI5L | 0.007 | 0.004 | hein_WMM WMM_only |
| RAB11FIP2 | EVI5L | 0.007 | 0.005 | hein_WMM WMM_only |
Images
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Complex HuMAP2_06358 has an average edge precision of 0.375 which is ranked 3577 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAB11FIP5 | HuMAP2_03348 HuMAP2_05097 HuMAP2_06358 HuMAP2_06461 |
| RAB11FIP1 | HuMAP2_03348 HuMAP2_06089 HuMAP2_06358 HuMAP2_06461 |
| RAB11B | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |
| RAB25 | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |
| RAB11FIP2 | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |
| SH3BP5 | HuMAP2_03348 HuMAP2_06358 |
| RAB11A | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |
| EVI5L | HuMAP2_06358 |