hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06359
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAB21L1 | Putative nucleotidyltransferase MAB21L1 (EC 2.7.7.-) (Protein mab-21-like 1) | UniProt NCBI |
| PBX2 | Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17) | UniProt NCBI |
| MEIS2 | Homeobox protein Meis2 (Meis1-related protein 1) | UniProt NCBI |
| PBX1 | Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL) | UniProt NCBI |
| PKNOX1 | Homeobox protein PKNOX1 (Homeobox protein PREP-1) (PBX/knotted homeobox 1) | UniProt NCBI |
| MEIS1 | Homeobox protein Meis1 | UniProt NCBI |
| PBX3 | Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3) | UniProt NCBI |
| PBX4 | Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4) | UniProt NCBI |
| MAB21L2 | Protein mab-21-like 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000790 | 0.00145586304602 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | nuclear chromatin |
| GO:0000981 | 0.00163727966613 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| WP:WP2857 | 0.00307359033351 | 0.333333333333 | PBX3 MEIS1 PBX1 | Mesodermal Commitment Pathway |
| GO:0000785 | 0.00457990869464 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | chromatin |
| KEGG:05202 | 0.00471517617195 | 0.333333333333 | PBX3 MEIS1 PBX1 | Transcriptional misregulation in cancer |
| GO:0003700 | 0.00566238683913 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | DNA-binding transcription factor activity |
| GO:0044454 | 0.00574740693261 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | nuclear chromosome part |
| GO:0000228 | 0.00690551858738 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | nuclear chromosome |
| REAC:R-HSA-5619507 | 0.00725406490738 | 0.333333333333 | PKNOX1 MEIS1 PBX1 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.00725406490738 | 0.333333333333 | PKNOX1 MEIS1 PBX1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| GO:0044427 | 0.0384546907947 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | chromosomal part |
| GO:0140110 | 0.0474357908379 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | transcription regulator activity |
| GO:0005694 | 0.049270844601 | 0.777777777778 | PBX2 PKNOX1 MEIS1 MEIS2 PBX4 PBX3 PBX1 | chromosome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MEIS2 | PBX1 | 1.0 | 0.949 | bioplex (MEIS2) bioplex_WMM |
| PKNOX1 | PBX1 | 1.0 | 0.949 | bioplex (PKNOX1) bioplex_WMM |
| MEIS2 | PBX2 | 1.0 | 0.949 | bioplex (MEIS2) bioplex_WMM |
| MEIS1 | MAB21L1 | 1.0 | 0.949 | bioplex (MAB21L1) bioplex_WMM |
| MEIS2 | PBX3 | 0.999 | 0.946 | bioplex (MEIS2) bioplex_WMM |
| PKNOX1 | PBX2 | 0.997 | 0.933 | bioplex (PKNOX1) bioplex_WMM |
| MEIS1 | MEIS2 | 0.99 | 0.909 | bioplex (MEIS2) bioplex_WMM |
| MEIS2 | MAB21L1 | 0.987 | 0.901 | bioplex (MAB21L1,MEIS2) bioplex_WMM |
| MEIS1 | MAB21L2 | 0.984 | 0.899 | bioplex (MAB21L2) bioplex_WMM |
| PKNOX1 | PBX4 | 0.971 | 0.881 | bioplex (PKNOX1) bioplex_WMM |
| MEIS2 | PBX4 | 0.958 | 0.863 | bioplex (MEIS2) bioplex_WMM |
| MEIS2 | MAB21L2 | 0.76 | 0.749 | bioplex (MAB21L2) bioplex_WMM |
| MAB21L1 | PBX2 | 0.733 | 0.738 | bioplex (MAB21L1) bioplex_WMM |
| MAB21L1 | PBX3 | 0.605 | 0.672 | bioplex (MAB21L1) bioplex_WMM |
| MAB21L1 | PBX1 | 0.308 | 0.503 | bioplex (MAB21L1) bioplex_WMM |
| PBX2 | PBX1 | 0.053 | 0.302 | bioplex_WMM youn_WMM fraction |
| PBX3 | PBX1 | 0.037 | 0.265 | bioplex_WMM WMM_only |
| MEIS1 | PBX3 | 0.029 | 0.232 | bioplex_WMM WMM_only |
| MEIS1 | PBX2 | 0.029 | 0.232 | bioplex_WMM WMM_only |
| MAB21L2 | PBX3 | 0.029 | 0.23 | bioplex (MAB21L2) bioplex_WMM |
| MAB21L2 | PBX2 | 0.026 | 0.22 | bioplex (MAB21L2) bioplex_WMM |
| PBX3 | PBX2 | 0.025 | 0.218 | bioplex_WMM WMM_only |
| MEIS1 | PBX1 | 0.025 | 0.212 | bioplex_WMM WMM_only |
| PBX4 | PBX2 | 0.01 | 0.121 | bioplex_WMM WMM_only |
| PBX4 | PBX1 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| PKNOX1 | PBX3 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| PBX4 | MAB21L1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| MEIS1 | PKNOX1 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| MEIS1 | PBX4 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| PBX4 | PBX3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| MEIS2 | PKNOX1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| MAB21L2 | PBX1 | 0.007 | 0.006 | bioplex (MAB21L2) bioplex_WMM |
Images
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Complex HuMAP2_06359 has an average edge precision of 0.479 which is ranked 2642 out of all 6965 complexes.
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