hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06365
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NAAA | N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (Acid ceramidase-like protein) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] | UniProt NCBI |
| GLDC | Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | UniProt NCBI |
| KIAA1143 | Uncharacterized protein KIAA1143 | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | UniProt NCBI |
| SEC24A | Protein transport protein Sec24A (SEC24-related protein A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1982 | 6.48142755071e-07 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| GO:0090110 | 8.53321565671e-07 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | COPII-coated vesicle cargo loading |
| GO:0030127 | 1.16343266976e-06 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | COPII vesicle coat |
| GO:0035459 | 7.5376630563e-06 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | vesicle cargo loading |
| KEGG:04141 | 2.12688843743e-05 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-983170 | 2.43429657674e-05 | 0.428571428571 | SEC23A SEC24D SEC24A | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 3.0945418259e-05 | 0.428571428571 | SEC23A SEC24D SEC24A | Cargo concentration in the ER |
| GO:0012507 | 0.000126379744832 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | ER to Golgi transport vesicle membrane |
| GO:0030120 | 0.000151242942759 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | vesicle coat |
| REAC:R-HSA-1655829 | 0.000206400686164 | 0.428571428571 | SEC23A SEC24D SEC24A | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| REAC:R-HSA-204005 | 0.000378157183208 | 0.428571428571 | SEC23A SEC24D SEC24A | COPII-mediated vesicle transport |
| GO:0051668 | 0.000385172296353 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | localization within membrane |
| GO:0090114 | 0.000609254189766 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | COPII-coated vesicle budding |
| GO:0048194 | 0.000919053594983 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | Golgi vesicle budding |
| GO:0048475 | 0.000919053594983 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | coated membrane |
| GO:0030134 | 0.000919053594983 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | COPII-coated ER to Golgi transport vesicle |
| GO:0030117 | 0.000919053594983 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | membrane coat |
| GO:0030660 | 0.00178932980587 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | Golgi-associated vesicle membrane |
| GO:0006900 | 0.00235209893628 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | vesicle budding from membrane |
| REAC:R-HSA-2132295 | 0.00263372684234 | 0.428571428571 | SEC23A SEC24D SEC24A | MHC class II antigen presentation |
| HP:0002868 | 0.00322839434563 | 0.285714285714 | SEC23A SEC24D | Narrow iliac wings |
| REAC:R-HSA-8957322 | 0.00337546107095 | 0.428571428571 | SEC23A SEC24D SEC24A | Metabolism of steroids |
| GO:0030658 | 0.00417229408607 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | transport vesicle membrane |
| REAC:R-HSA-199977 | 0.00503540377545 | 0.428571428571 | SEC23A SEC24D SEC24A | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.00812379143266 | 0.428571428571 | SEC23A SEC24D SEC24A | Transport to the Golgi and subsequent modification |
| GO:0030662 | 0.009800844161 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | coated vesicle membrane |
| GO:0005798 | 0.011395306347 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | Golgi-associated vesicle |
| GO:0006888 | 0.0375020380686 | 0.571428571429 | SEC23A SEC24D SEC23B SEC24A | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-446203 | 0.0383313102015 | 0.428571428571 | SEC23A SEC24D SEC24A | Asparagine N-linked glycosylation |
| CORUM:7139 | 0.0499886427319 | 0.142857142857 | SEC23A | SEC23-SEC24 adaptor complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SEC23B | SEC23A | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24A | SEC24D | 0.803 | 0.766 | bioplex_WMM Malo fraction |
| SEC23A | SEC24A | 0.776 | 0.752 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC23B | SEC24D | 0.679 | 0.708 | bioplex_WMM Malo fraction |
| SEC23A | SEC24D | 0.551 | 0.644 | bioplex_WMM Malo fraction |
| SEC23B | SEC24A | 0.072 | 0.354 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24D | NAAA | 0.048 | 0.296 | bioplex (NAAA) bioplex_WMM |
| SEC24D | GLDC | 0.043 | 0.273 | fraction |
| SEC24A | KIAA1143 | 0.043 | 0.269 | youn_WMM fraction |
| SEC23B | GLDC | 0.035 | 0.265 | bioplex_WMM fraction |
| SEC23A | GLDC | 0.009 | 0.116 | fraction treiber_WMM |
| SEC23A | KIAA1143 | 0.008 | 0.086 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SEC23B | KIAA1143 | 0.0 | 0.011 | youn_WMM gupta_WMM fraction |
| SEC24A | NAAA | 0.0 | 0.0 | bioplex (NAAA) bioplex_WMM |
Images
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Complex HuMAP2_06365 has an average edge precision of 0.392 which is ranked 3407 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NAAA | HuMAP2_02617 HuMAP2_02981 HuMAP2_05176 HuMAP2_06365 |
| GLDC | HuMAP2_02576 HuMAP2_02617 HuMAP2_04961 HuMAP2_05176 HuMAP2_06365 |
| SEC24D | HuMAP2_00758 HuMAP2_01495 HuMAP2_02617 HuMAP2_05176 HuMAP2_06365 |
| KIAA1143 | HuMAP2_02072 HuMAP2_06365 |
| SEC23B | HuMAP2_00758 HuMAP2_02617 HuMAP2_05176 HuMAP2_06134 HuMAP2_06365 |
| SEC23A | HuMAP2_00758 HuMAP2_02478 HuMAP2_05176 HuMAP2_06365 |
| SEC24A | HuMAP2_00758 HuMAP2_01495 HuMAP2_02072 HuMAP2_02617 HuMAP2_03296 HuMAP2_05176 HuMAP2_06365 |