hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06369
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LRP4 | Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) | UniProt NCBI |
| SORL1 | Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) | UniProt NCBI |
| LRP8 | Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) | UniProt NCBI |
| LRPAP1 | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | UniProt NCBI |
| VLDLR | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005041 | 7.62415024416e-05 | 0.6 | VLDLR LRP8 SORL1 | low-density lipoprotein particle receptor activity |
| GO:0030228 | 0.000149729915117 | 0.6 | VLDLR LRP8 SORL1 | lipoprotein particle receptor activity |
| GO:0038025 | 0.00450823411379 | 0.4 | VLDLR LRP8 | reelin receptor activity |
| GO:0038024 | 0.00703245670927 | 0.6 | VLDLR LRP8 SORL1 | cargo receptor activity |
| GO:0038026 | 0.0135228859698 | 0.4 | VLDLR LRP8 | reelin-mediated signaling pathway |
| GO:0030229 | 0.0270421395626 | 0.4 | VLDLR LRP8 | very-low-density lipoprotein particle receptor activity |
| HP:0000504 | 0.0360700347925 | 0.8 | VLDLR LRPAP1 LRP4 SORL1 | Abnormality of vision |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LRP8 | LRPAP1 | 0.546 | 0.643 | bioplex (LRPAP1) bioplex_WMM |
| LRPAP1 | VLDLR | 0.395 | 0.555 | bioplex (LRPAP1) bioplex_WMM |
| LRPAP1 | LRP4 | 0.057 | 0.324 | bioplex (LRPAP1) bioplex_WMM |
| LRPAP1 | SORL1 | 0.039 | 0.266 | bioplex (LRPAP1) bioplex_WMM |
| LRP4 | SORL1 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| LRP8 | VLDLR | 0.008 | 0.085 | bioplex_WMM WMM_only |
| LRP4 | VLDLR | 0.008 | 0.062 | bioplex_WMM WMM_only |
| LRP8 | LRP4 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| LRP8 | SORL1 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| VLDLR | SORL1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06369 has an average edge precision of 0.207 which is ranked 6074 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LRP4 | HuMAP2_03202 HuMAP2_05261 HuMAP2_06369 |
| SORL1 | HuMAP2_04155 HuMAP2_06369 |
| LRP8 | HuMAP2_00984 HuMAP2_03202 HuMAP2_06369 |
| LRPAP1 | HuMAP2_00984 HuMAP2_03202 HuMAP2_06369 |
| VLDLR | HuMAP2_03202 HuMAP2_06369 HuMAP2_06794 |