hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06376
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TMEM200A | Transmembrane protein 200A | UniProt NCBI |
| BET1L | BET1-like protein (Golgi SNARE with a size of 15 kDa) (GOS-15) (GS15) (Vesicle transport protein GOS15) | UniProt NCBI |
| GOSR2 | Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) | UniProt NCBI |
| SEC22B | Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1) | UniProt NCBI |
| BET1 | BET1 homolog (hBET1) (Golgi vesicular membrane-trafficking protein p18) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04130 | 4.17116504798e-09 | 0.8 | SEC22B BET1L BET1 GOSR2 | SNARE interactions in vesicular transport |
| GO:0005484 | 3.33813219873e-06 | 0.8 | SEC22B BET1L BET1 GOSR2 | SNAP receptor activity |
| REAC:R-HSA-199977 | 6.22658703089e-06 | 0.8 | SEC22B BET1L BET1 GOSR2 | ER to Golgi Anterograde Transport |
| GO:0048280 | 9.08002798436e-06 | 0.6 | GOSR2 BET1 SEC22B | vesicle fusion with Golgi apparatus |
| REAC:R-HSA-948021 | 1.18707037161e-05 | 0.8 | SEC22B BET1L BET1 GOSR2 | Transport to the Golgi and subsequent modification |
| GO:0031201 | 1.98600319243e-05 | 0.8 | SEC22B BET1L BET1 GOSR2 | SNARE complex |
| REAC:R-HSA-446203 | 9.68088693554e-05 | 0.8 | SEC22B BET1L BET1 GOSR2 | Asparagine N-linked glycosylation |
| REAC:R-HSA-204005 | 9.72902207652e-05 | 0.6 | GOSR2 BET1 SEC22B | COPII-mediated vesicle transport |
| REAC:R-HSA-6807878 | 0.000397120285508 | 0.6 | BET1L BET1 GOSR2 | COPI-mediated anterograde transport |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | SEC22B BET1L BET1 GOSR2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | SEC22B BET1L BET1 GOSR2 | Vesicle-mediated transport |
| REAC:R-HSA-6811442 | 0.00334585987792 | 0.6 | SEC22B BET1L GOSR2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-5694530 | 0.00472180750517 | 0.4 | GOSR2 SEC22B | Cargo concentration in the ER |
| GO:0006888 | 0.0054619312421 | 0.8 | SEC22B BET1L BET1 GOSR2 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0033116 | 0.00703245670927 | 0.6 | GOSR2 BET1 SEC22B | endoplasmic reticulum-Golgi intermediate compartment membrane |
| REAC:R-HSA-6811438 | 0.0126969553517 | 0.4 | BET1L GOSR2 | Intra-Golgi traffic |
| GO:0048208 | 0.0308999432136 | 0.6 | GOSR2 BET1 SEC22B | COPII vesicle coating |
| GO:0048207 | 0.0308999432136 | 0.6 | GOSR2 BET1 SEC22B | vesicle targeting, rough ER to cis-Golgi |
| REAC:R-HSA-597592 | 0.035484350726 | 0.8 | SEC22B BET1L BET1 GOSR2 | Post-translational protein modification |
| GO:0006901 | 0.0376065209581 | 0.6 | GOSR2 BET1 SEC22B | vesicle coating |
| GO:0090114 | 0.0412952841175 | 0.6 | GOSR2 BET1 SEC22B | COPII-coated vesicle budding |
| GO:0048199 | 0.0452171392335 | 0.6 | GOSR2 BET1 SEC22B | vesicle targeting, to, from or within Golgi |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BET1 | SEC22B | 0.06 | 0.336 | hein_WMM bioplex (SEC22B) bioplex_WMM youn_WMM gupta_WMM |
| SEC22B | BET1L | 0.056 | 0.315 | bioplex (SEC22B) bioplex_WMM youn_WMM gupta_WMM |
| TMEM200A | BET1L | 0.051 | 0.301 | bioplex (TMEM200A) bioplex_WMM |
| GOSR2 | SEC22B | 0.042 | 0.27 | hein_WMM bioplex (SEC22B) bioplex_WMM youn_WMM gupta_WMM |
| BET1 | BET1L | 0.009 | 0.111 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GOSR2 | BET1 | 0.009 | 0.108 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GOSR2 | BET1L | 0.008 | 0.067 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SEC22B | TMEM200A | 0.005 | 0.012 | bioplex (TMEM200A) |
Images
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Complex HuMAP2_06376 has an average edge precision of 0.19 which is ranked 6306 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TMEM200A | HuMAP2_00997 HuMAP2_06376 |
| BET1L | HuMAP2_00997 HuMAP2_06376 |
| GOSR2 | HuMAP2_00576 HuMAP2_00644 HuMAP2_06376 |
| SEC22B | HuMAP2_00854 HuMAP2_02070 HuMAP2_02979 HuMAP2_04522 HuMAP2_06376 |
| BET1 | HuMAP2_00766 HuMAP2_00854 HuMAP2_02979 HuMAP2_04522 HuMAP2_06376 |