hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06383
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KAT6B | Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor) | UniProt NCBI |
| KAT6A | Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220) | UniProt NCBI |
| KAT7 | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) | UniProt NCBI |
| MEAF6 | Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91) | UniProt NCBI |
| JADE1 | Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) | UniProt NCBI |
| JADE2 | E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15) | UniProt NCBI |
| BRD1 | Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2) | UniProt NCBI |
| JADE3 | Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16) | UniProt NCBI |
| BRPF3 | Bromodomain and PHD finger-containing protein 3 | UniProt NCBI |
| ING4 | Inhibitor of growth protein 4 (p29ING4) | UniProt NCBI |
| ING5 | Inhibitor of growth protein 5 (p28ING5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0043966 | 9.35274467815e-24 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | histone H3 acetylation |
| GO:0000123 | 1.94765008873e-21 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | histone acetyltransferase complex |
| GO:0031248 | 8.01376338731e-21 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | protein acetyltransferase complex |
| GO:1902493 | 8.01376338731e-21 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | acetyltransferase complex |
| REAC:R-HSA-3214847 | 8.75321165457e-21 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | HATs acetylate histones |
| GO:0016573 | 7.75806366311e-20 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | histone acetylation |
| GO:0018393 | 9.60739800569e-20 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | internal peptidyl-lysine acetylation |
| GO:0006475 | 1.61112337692e-19 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | internal protein amino acid acetylation |
| GO:0018394 | 1.78153065717e-19 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | peptidyl-lysine acetylation |
| GO:0006473 | 2.96098325833e-18 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | protein acetylation |
| REAC:R-HSA-4839726 | 1.19347923716e-17 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | Chromatin organization |
| REAC:R-HSA-3247509 | 1.19347923716e-17 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | Chromatin modifying enzymes |
| GO:0043543 | 3.34497260606e-17 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | protein acylation |
| GO:0043983 | 1.52515442273e-15 | 0.545454545455 | MEAF6 ING4 JADE3 JADE1 JADE2 KAT7 | histone H4-K12 acetylation |
| CORUM:7253 | 5.12134059541e-15 | 0.454545454545 | KAT6A ING5 BRPF3 KAT6B MEAF6 | ING5 (BRPF3, MOZ, MORF) complex |
| CORUM:7252 | 5.12134059541e-15 | 0.454545454545 | KAT6A ING5 BRD1 KAT6B MEAF6 | ING5 (BRPF2, MOZ, MORF) complex |
| GO:0018205 | 5.4065006756e-15 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | peptidyl-lysine modification |
| GO:0070776 | 1.06730077033e-14 | 0.545454545455 | KAT6A MEAF6 BRPF3 KAT6B ING5 BRD1 | MOZ/MORF histone acetyltransferase complex |
| GO:0070775 | 1.06730077033e-14 | 0.545454545455 | KAT6A MEAF6 BRPF3 KAT6B ING5 BRD1 | H3 histone acetyltransferase complex |
| GO:0016570 | 2.2587374919e-14 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | histone modification |
| GO:0016569 | 3.73877475428e-14 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | covalent chromatin modification |
| GO:0043981 | 7.61364007486e-12 | 0.545454545455 | MEAF6 ING4 JADE3 JADE1 JADE2 KAT7 | histone H4-K5 acetylation |
| GO:0043982 | 7.61364007486e-12 | 0.545454545455 | MEAF6 ING4 JADE3 JADE1 JADE2 KAT7 | histone H4-K8 acetylation |
| CORUM:7254 | 1.08938230665e-11 | 0.363636363636 | ING5 KAT7 JADE2 MEAF6 | ING5 complex (ING5, JADE2, KAT7, MEAF6) |
| CORUM:1352 | 1.08938230665e-11 | 0.363636363636 | MEAF6 ING4 KAT7 JADE1 | ING4 complex (ING4, JADE1, KAT7, MEAF6) |
| CORUM:2847 | 1.08938230665e-11 | 0.363636363636 | MEAF6 ING4 KAT7 JADE2 | ING4 complex (ING4, JADE2, KAT7, MEAF6) |
| CORUM:2848 | 1.08938230665e-11 | 0.363636363636 | MEAF6 ING4 KAT7 JADE3 | ING4 complex (ING4, JADE3, KAT7, MEAF6) |
| CORUM:2858 | 1.08938230665e-11 | 0.363636363636 | ING5 MEAF6 KAT7 JADE1 | ING5 complex (ING5, JADE1, KAT7, MEAF6) |
| CORUM:7255 | 1.08938230665e-11 | 0.363636363636 | ING5 JADE3 KAT7 MEAF6 | ING5 complex (ING5, JADE3, KAT7, MEAF6) |
| GO:0006325 | 1.48016959943e-11 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | chromatin organization |
| CORUM:2859 | 5.44486299702e-11 | 0.363636363636 | KAT6A ING5 KAT6B MEAF6 | ING5 (BRPF1, MOZ, MORF) complex |
| GO:1990234 | 1.12811627111e-10 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | transferase complex |
| GO:0018193 | 1.35559358038e-09 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | peptidyl-amino acid modification |
| GO:0044451 | 2.3325386199e-09 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | nucleoplasm part |
| REAC:R-HSA-6804758 | 2.34572764521e-09 | 0.454545454545 | KAT6A ING5 BRPF3 BRD1 MEAF6 | Regulation of TP53 Activity through Acetylation |
| GO:0051276 | 2.59800484238e-09 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | chromosome organization |
| GO:0043967 | 3.45425357653e-08 | 0.545454545455 | MEAF6 ING4 JADE3 JADE1 JADE2 KAT7 | histone H4 acetylation |
| GO:1902494 | 4.25058779257e-08 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | catalytic complex |
| CORUM:0000000 | 6.27334655689e-06 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | CORUM root |
| REAC:R-HSA-5633007 | 1.17551316634e-05 | 0.454545454545 | KAT6A ING5 BRPF3 BRD1 MEAF6 | Regulation of TP53 Activity |
| GO:0042393 | 5.13260481119e-05 | 0.545454545455 | KAT6A ING4 KAT6B ING5 BRD1 KAT7 | histone binding |
| REAC:R-HSA-3700989 | 0.000610699867202 | 0.454545454545 | KAT6A ING5 BRPF3 BRD1 MEAF6 | Transcriptional Regulation by TP53 |
| GO:0006464 | 0.000853806756546 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | cellular protein modification process |
| GO:0036211 | 0.000853806756546 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | protein modification process |
| GO:0006996 | 0.0013915659238 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | organelle organization |
| GO:0043412 | 0.00161081747965 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | macromolecule modification |
| GO:0005654 | 0.0021313263302 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | nucleoplasm |
| GO:0004402 | 0.0028995469326 | 0.363636363636 | KAT6A MEAF6 KAT6B KAT7 | histone acetyltransferase activity |
| GO:0061733 | 0.00334684762898 | 0.363636363636 | KAT6A MEAF6 KAT6B KAT7 | peptide-lysine-N-acetyltransferase activity |
| GO:0034212 | 0.00602588334679 | 0.363636363636 | KAT6A MEAF6 KAT6B KAT7 | peptide N-acetyltransferase activity |
| GO:0008080 | 0.0105990723032 | 0.363636363636 | KAT6A MEAF6 KAT6B KAT7 | N-acetyltransferase activity |
| GO:0044267 | 0.0147494969025 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | cellular protein metabolic process |
| GO:0031981 | 0.0170336395485 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | nuclear lumen |
| GO:0016410 | 0.0199147327968 | 0.363636363636 | KAT6A MEAF6 KAT6B KAT7 | N-acyltransferase activity |
| GO:0016407 | 0.0258322357025 | 0.363636363636 | KAT6A MEAF6 KAT6B KAT7 | acetyltransferase activity |
| GO:0044428 | 0.0345199601716 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | nuclear part |
| GO:0019538 | 0.0348922309154 | 1.0 | MEAF6 KAT7 JADE3 JADE1 BRD1 KAT6A ING5 JADE2 BRPF3 KAT6B ING4 | protein metabolic process |
| MIRNA:hsa-miR-3154 | 0.0366000742938 | 0.272727272727 | MEAF6 ING4 JADE2 | hsa-miR-3154 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| JADE2 | ING4 | 1.0 | 0.949 | hein_WMM bioplex (JADE2) bioplex_WMM hein (ING4) |
| KAT7 | JADE2 | 1.0 | 0.949 | hein_WMM bioplex (JADE2) bioplex_WMM |
| KAT7 | JADE1 | 0.995 | 0.924 | hein_WMM bioplex (JADE1,KAT7) bioplex_WMM |
| JADE2 | ING5 | 0.994 | 0.919 | bioplex (JADE2) bioplex_WMM |
| MEAF6 | JADE3 | 0.947 | 0.857 | hein_WMM bioplex (MEAF6) bioplex_WMM |
| ING4 | MEAF6 | 0.937 | 0.85 | hein_WMM bioplex (MEAF6) bioplex_WMM hein (ING4) |
| JADE2 | MEAF6 | 0.886 | 0.817 | hein_WMM bioplex (JADE2,MEAF6) bioplex_WMM |
| KAT7 | JADE3 | 0.662 | 0.698 | hein_WMM bioplex (KAT7) bioplex_WMM youn_WMM |
| MEAF6 | KAT6B | 0.623 | 0.678 | bioplex (MEAF6) bioplex_WMM |
| JADE1 | MEAF6 | 0.555 | 0.647 | hein_WMM bioplex (MEAF6) bioplex_WMM |
| KAT7 | BRPF3 | 0.467 | 0.604 | bioplex (KAT7) bioplex_WMM youn_WMM |
| ING5 | MEAF6 | 0.466 | 0.604 | bioplex (MEAF6) bioplex_WMM |
| MEAF6 | BRPF3 | 0.461 | 0.6 | bioplex (MEAF6) bioplex_WMM |
| KAT7 | MEAF6 | 0.165 | 0.42 | hein_WMM bioplex (KAT7,MEAF6) bioplex_WMM |
| KAT7 | BRD1 | 0.153 | 0.412 | hein_WMM bioplex (KAT7) bioplex_WMM youn_WMM |
| MEAF6 | KAT6A | 0.129 | 0.399 | hein_WMM bioplex (MEAF6) bioplex_WMM |
| ING4 | JADE3 | 0.064 | 0.348 | hein_WMM bioplex_WMM hein (ING4) |
| JADE1 | ING4 | 0.052 | 0.299 | hein_WMM bioplex_WMM hein (ING4) |
| KAT7 | ING5 | 0.045 | 0.284 | hein_WMM bioplex (KAT7) bioplex_WMM |
| KAT7 | ING4 | 0.028 | 0.229 | hein_WMM bioplex_WMM hein (ING4) |
| ING5 | ING4 | 0.011 | 0.137 | bioplex_WMM WMM_only |
| JADE1 | JADE3 | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| JADE3 | BRPF3 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| MEAF6 | BRD1 | 0.01 | 0.139 | hein_WMM bioplex_WMM WMM_only |
| JADE1 | BRPF3 | 0.01 | 0.128 | bioplex_WMM WMM_only |
| ING5 | BRPF3 | 0.01 | 0.128 | bioplex_WMM WMM_only |
| ING4 | BRD1 | 0.01 | 0.118 | hein_WMM hein (ING4) |
| ING5 | JADE3 | 0.01 | 0.12 | hein_WMM bioplex_WMM WMM_only |
| JADE1 | ING5 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| JADE3 | BRD1 | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| JADE1 | BRD1 | 0.009 | 0.108 | hein_WMM bioplex_WMM WMM_only |
| KAT6B | KAT6A | 0.009 | 0.095 | bioplex_WMM WMM_only |
| JADE2 | JADE3 | 0.009 | 0.096 | hein_WMM bioplex_WMM WMM_only |
| JADE1 | JADE2 | 0.009 | 0.099 | hein_WMM bioplex_WMM WMM_only |
| BRD1 | BRPF3 | 0.009 | 0.098 | bioplex_WMM youn_WMM WMM_only |
| KAT6A | BRPF3 | 0.008 | 0.094 | bioplex_WMM youn_WMM WMM_only |
| ING4 | KAT6B | 0.008 | 0.091 | bioplex_WMM WMM_only |
| JADE2 | KAT6B | 0.008 | 0.091 | bioplex_WMM WMM_only |
| ING4 | KAT6A | 0.008 | 0.091 | bioplex_WMM WMM_only |
| KAT6B | JADE3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| KAT6B | BRPF3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| JADE2 | KAT6A | 0.008 | 0.091 | bioplex_WMM WMM_only |
| ING5 | KAT6B | 0.008 | 0.087 | bioplex_WMM WMM_only |
| ING5 | BRD1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| JADE1 | KAT6B | 0.008 | 0.087 | bioplex_WMM WMM_only |
| JADE1 | KAT6A | 0.008 | 0.087 | bioplex_WMM WMM_only |
| KAT7 | KAT6A | 0.008 | 0.085 | bioplex_WMM youn_WMM WMM_only |
| KAT7 | KAT6B | 0.008 | 0.085 | bioplex_WMM WMM_only |
| JADE2 | BRPF3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| ING4 | BRPF3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| JADE3 | KAT6A | 0.008 | 0.067 | hein_WMM bioplex_WMM WMM_only |
| JADE2 | BRD1 | 0.008 | 0.032 | hein_WMM WMM_only |
| BRD1 | KAT6A | 0.007 | 0.007 | hein_WMM WMM_only |
| ING5 | KAT6A | 0.006 | 0.005 | hein_WMM bioplex_WMM hein (KAT6A) |
| KAT6B | BRD1 | 0.004 | 0.01 | fraction |
Images
Click to enlarge
Complex HuMAP2_06383 has an average edge precision of 0.285 which is ranked 4807 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KAT6B | HuMAP2_01906 HuMAP2_05301 HuMAP2_06383 |
| KAT6A | HuMAP2_06383 |
| KAT7 | HuMAP2_00963 HuMAP2_02043 HuMAP2_06324 HuMAP2_06383 |
| MEAF6 | HuMAP2_01817 HuMAP2_01906 HuMAP2_03532 HuMAP2_03860 HuMAP2_05301 HuMAP2_06383 HuMAP2_06741 |
| JADE1 | HuMAP2_00963 HuMAP2_06324 HuMAP2_06383 |
| JADE2 | HuMAP2_00983 HuMAP2_02043 HuMAP2_06383 |
| BRD1 | HuMAP2_06324 HuMAP2_06383 |
| JADE3 | HuMAP2_03532 HuMAP2_05301 HuMAP2_06324 HuMAP2_06383 |
| BRPF3 | HuMAP2_06383 |
| ING4 | HuMAP2_00983 HuMAP2_02043 HuMAP2_06383 |
| ING5 | HuMAP2_00983 HuMAP2_02043 HuMAP2_06383 |