hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06387

Confidence: Medium High

Genename	Protein Name	Links
TPM1	Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)	UniProt NCBI
TPM2	Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)	UniProt NCBI
MYH6	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	UniProt NCBI
TPM4	Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)	UniProt NCBI
MYO1B	Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)	UniProt NCBI
ACTN4	Alpha-actinin-4 (Non-muscle alpha-actinin 4)	UniProt NCBI
TNNI1	Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)	UniProt NCBI
ACTN1	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP383	2.16722457984e-13	0.75	MYH6 TPM1 ACTN4 TPM4 TNNI1 TPM2	Striated Muscle Contraction Pathway
GO:0030048	2.80996417058e-10	0.875	MYH6 TPM4 TPM1 ACTN4 MYO1B TNNI1 TPM2	actin filament-based movement
REAC:R-HSA-390522	5.2544449687e-10	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	Striated Muscle Contraction
GO:0015629	9.67735629038e-09	1.0	ACTN1 MYH6 TPM4 TPM1 ACTN4 MYO1B TNNI1 TPM2	actin cytoskeleton
GO:0030029	2.28885091057e-07	1.0	ACTN1 MYH6 TPM4 TPM1 ACTN4 MYO1B TNNI1 TPM2	actin filament-based process
GO:0030049	2.28991321124e-07	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	muscle filament sliding
GO:0033275	2.28991321124e-07	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	actin-myosin filament sliding
GO:0051015	9.30936297466e-07	0.75	ACTN1 TPM4 TPM1 ACTN4 MYO1B TPM2	actin filament binding
REAC:R-HSA-397014	1.87102943214e-06	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	Muscle contraction
KEGG:04260	2.07425291044e-06	0.5	MYH6 TPM1 TPM2 TPM4	Cardiac muscle contraction
KEGG:05410	2.68695643145e-06	0.5	MYH6 TPM1 TPM2 TPM4	Hypertrophic cardiomyopathy (HCM)
KEGG:05414	3.267227105e-06	0.5	MYH6 TPM1 TPM2 TPM4	Dilated cardiomyopathy (DCM)
GO:0005865	8.24534072683e-06	0.5	TPM1 TNNI1 TPM2 TPM4	striated muscle thin filament
GO:0036379	1.24434934399e-05	0.5	TPM1 TNNI1 TPM2 TPM4	myofilament
GO:0070252	1.57602037409e-05	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	actin-mediated cell contraction
KEGG:04261	1.75968977537e-05	0.5	MYH6 TPM1 TPM2 TPM4	Adrenergic signaling in cardiomyocytes
GO:0005862	2.03382379613e-05	0.375	TPM1 TPM2 TPM4	muscle thin filament tropomyosin
GO:0099512	2.3908697663e-05	0.875	ACTN1 MYH6 TPM1 TPM4 MYO1B TNNI1 TPM2	supramolecular fiber
GO:0099081	2.59065254637e-05	0.875	ACTN1 MYH6 TPM1 TPM4 MYO1B TNNI1 TPM2	supramolecular polymer
GO:0099080	2.62530059887e-05	0.875	ACTN1 MYH6 TPM1 TPM4 MYO1B TNNI1 TPM2	supramolecular complex
GO:0005884	2.91101691159e-05	0.625	TPM1 MYO1B ACTN1 TPM2 TPM4	actin filament
GO:0003779	3.98359373309e-05	0.75	ACTN1 TPM4 TPM1 ACTN4 MYO1B TPM2	actin binding
GO:0030017	8.219111489e-05	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	sarcomere
REAC:R-HSA-445355	9.76573076151e-05	0.375	TPM1 TPM2 TPM4	Smooth Muscle Contraction
GO:0030016	0.000138895560635	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	myofibril
GO:0044449	0.000149864331431	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	contractile fiber part
GO:0043292	0.000193820981193	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	contractile fiber
MIRNA:hsa-miR-1-3p	0.000237050282163	0.75	ACTN1 TPM4 TPM1 ACTN4 MYO1B TPM2	hsa-miR-1-3p
GO:0006928	0.000284154798906	1.0	ACTN1 MYH6 TPM4 TPM1 ACTN4 MYO1B TNNI1 TPM2	movement of cell or subcellular component
GO:0005856	0.000452284610928	1.0	ACTN1 MYH6 TPM4 TPM1 ACTN4 MYO1B TNNI1 TPM2	cytoskeleton
GO:0006936	0.00169430181981	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	muscle contraction
GO:0030036	0.00179387491837	0.75	MYH6 TPM1 TPM4 TPM2 MYO1B ACTN1	actin cytoskeleton organization
GO:0097435	0.00181549203686	0.75	MYH6 TPM1 TPM4 TPM2 MYO1B ACTN1	supramolecular fiber organization
GO:0003012	0.00379847061121	0.625	MYH6 TPM1 TNNI1 TPM2 TPM4	muscle system process
GO:0007015	0.00709427990716	0.625	TPM1 MYO1B ACTN1 TPM2 TPM4	actin filament organization
GO:0044430	0.0075667656243	0.875	ACTN1 MYH6 TPM1 TPM4 MYO1B TNNI1 TPM2	cytoskeletal part
REAC:R-HSA-373753	0.0102847477438	0.25	ACTN4 ACTN1	Nephrin family interactions
GO:0008092	0.0154530953556	0.75	ACTN1 TPM4 TPM1 ACTN4 MYO1B TPM2	cytoskeletal protein binding
HP:0010876	0.0169884602437	0.5	TPM1 ACTN4 TPM2 MYH6	Abnormal circulating protein level
HP:0001644	0.0201288940439	0.375	TPM1 TPM2 MYH6	Dilated cardiomyopathy
GO:0044877	0.0253046645697	0.75	ACTN1 TPM4 TPM1 ACTN4 MYO1B TPM2	protein-containing complex binding
KEGG:04520	0.0279665014883	0.25	ACTN4 ACTN1	Adherens junction
GO:0099513	0.0291592221593	0.625	TPM1 MYO1B ACTN1 TPM2 TPM4	polymeric cytoskeletal fiber
WP:WP2118	0.0294384226193	0.25	ACTN4 ACTN1	Arrhythmogenic Right Ventricular Cardiomyopathy
GO:0008307	0.039179823435	0.375	TPM1 TPM2 TPM4	structural constituent of muscle
KEGG:05146	0.042374965807	0.25	ACTN4 ACTN1	Amoebiasis
KEGG:04670	0.0454007036402	0.25	ACTN4 ACTN1	Leukocyte transendothelial migration
CORUM:5655	0.0497224828424	0.125	ACTN4	Ternary complex (LRRC7, CAMK2a, ACTN4)
CORUM:6788	0.0497224828424	0.125	ACTN4	SLC9A3R1-ACTN4 complex
CORUM:4025	0.0497224828424	0.125	ACTN1	ACTN1-PARVB complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TPM4	TPM1	1.0	0.949	hein_WMM bioplex (TPM1) bioplex_WMM youn_WMM hein (TPM1,TPM4) gupta_WMM
TPM1	TPM2	1.0	0.949	hein_WMM bioplex (TPM1) bioplex_WMM hein (TPM1)
MYH6	TPM2	0.985	0.899	Guru fraction
TPM1	ACTN4	0.978	0.894	hein_WMM bioplex (TPM1) bioplex_WMM Guru youn_WMM hein (TPM1) gupta_WMM fraction
MYH6	TPM1	0.957	0.863	bioplex_WMM Guru fraction
TPM4	ACTN1	0.918	0.841	hein_WMM bioplex_WMM Guru gupta_WMM fraction
TPM1	ACTN1	0.898	0.823	hein_WMM bioplex_WMM Guru youn_WMM fraction
ACTN4	ACTN1	0.859	0.796	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
TPM4	ACTN4	0.811	0.771	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
TPM2	ACTN4	0.801	0.766	hein_WMM bioplex_WMM Guru fraction
TPM2	ACTN1	0.548	0.642	hein_WMM bioplex_WMM Guru fraction
TPM1	MYO1B	0.092	0.355	hein_WMM bioplex_WMM youn_WMM hein (TPM1) gupta_WMM
TPM2	TNNI1	0.078	0.352	Guru fraction
TPM1	TNNI1	0.064	0.348	Guru fraction
TPM4	MYO1B	0.008	0.082	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
ACTN1	MYO1B	0.008	0.038	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM
ACTN4	MYO1B	0.007	0.009	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
TPM2	MYO1B	0.007	0.009	hein_WMM WMM_only
MYH6	TPM4	0.007	0.004	bioplex_WMM WMM_only
TPM4	TPM2	0.006	0.007	hein_WMM bioplex_WMM WMM_only
MYH6	TNNI1	0.0	0.001	Guru fraction

Images

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Complex HuMAP2_06387 has an average edge precision of 0.495 which is ranked 2528 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TPM1	HuMAP2_01077 HuMAP2_04204 HuMAP2_06151 HuMAP2_06387
TPM2	HuMAP2_02652 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387 HuMAP2_06391
MYH6	HuMAP2_00710 HuMAP2_01870 HuMAP2_02652 HuMAP2_03104 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387
TPM4	HuMAP2_00779 HuMAP2_04204 HuMAP2_06151 HuMAP2_06387
MYO1B	HuMAP2_06387
ACTN4	HuMAP2_02652 HuMAP2_04204 HuMAP2_06387
TNNI1	HuMAP2_02652 HuMAP2_06061 HuMAP2_06387
ACTN1	HuMAP2_02652 HuMAP2_04204 HuMAP2_06387

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06387