hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06391
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TPM2 | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | UniProt NCBI |
| MYH7 | Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta) | UniProt NCBI |
| MYH3 | Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0008800 | 6.81436112906e-06 | 1.0 | TPM2 MYH3 MYH7 | Limited hip movement |
| HP:0003043 | 1.73683106826e-05 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the shoulder |
| HP:0000275 | 4.17290581335e-05 | 1.0 | TPM2 MYH3 MYH7 | Narrow face |
| HP:0000274 | 6.97344203346e-05 | 1.0 | TPM2 MYH3 MYH7 | Small face |
| HP:0003019 | 0.00010497618293 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the wrist |
| HP:0004673 | 0.00011127353112 | 1.0 | TPM2 MYH3 MYH7 | Decreased facial expression |
| HP:0003755 | 0.000132571377575 | 0.666666666667 | TPM2 MYH7 | Type 1 fibers relatively smaller than type 2 fibers |
| HP:0100830 | 0.000132571377575 | 0.666666666667 | TPM2 MYH3 | Round ear |
| HP:0005346 | 0.000146559219039 | 1.0 | TPM2 MYH3 MYH7 | Abnormal facial expression |
| HP:0001558 | 0.000289280314467 | 1.0 | TPM2 MYH3 MYH7 | Decreased fetal movement |
| HP:0001557 | 0.000347411326147 | 1.0 | TPM2 MYH3 MYH7 | Prenatal movement abnormality |
| HP:0032341 | 0.00039764290247 | 0.666666666667 | TPM2 MYH7 | Reduced forced vital capacity |
| HP:0003049 | 0.000485986227107 | 0.666666666667 | TPM2 MYH3 | Ulnar deviation of the wrist |
| HP:0002877 | 0.000583157354768 | 0.666666666667 | TPM2 MYH7 | Nocturnal hypoventilation |
| HP:0002827 | 0.000596393717035 | 1.0 | TPM2 MYH3 MYH7 | Hip dislocation |
| WP:WP383 | 0.000637825429265 | 0.666666666667 | TPM2 MYH3 | Striated Muscle Contraction Pathway |
| GO:0033275 | 0.000766145507331 | 1.0 | TPM2 MYH3 MYH7 | actin-myosin filament sliding |
| GO:0030049 | 0.000766145507331 | 1.0 | TPM2 MYH3 MYH7 | muscle filament sliding |
| HP:0005986 | 0.000803978270478 | 0.666666666667 | MYH7 MYH3 | Limitation of neck motion |
| HP:0030311 | 0.000996974273967 | 1.0 | TPM2 MYH3 MYH7 | Lower extremity joint dislocation |
| HP:0009055 | 0.00106009615223 | 0.666666666667 | TPM2 MYH7 | Generalized limb muscle atrophy |
| HP:0001384 | 0.00123534395034 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the hip joint |
| KEGG:04260 | 0.00127210962765 | 0.666666666667 | TPM2 MYH7 | Cardiac muscle contraction |
| HP:0005262 | 0.00135057313499 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the synovia |
| HP:0001623 | 0.00135150150266 | 0.666666666667 | TPM2 MYH3 | Breech presentation |
| KEGG:05410 | 0.00144586300556 | 0.666666666667 | TPM2 MYH7 | Hypertrophic cardiomyopathy (HCM) |
| HP:0001762 | 0.0015089678546 | 1.0 | TPM2 MYH3 MYH7 | Talipes equinovarus |
| KEGG:05414 | 0.00159284054118 | 0.666666666667 | TPM2 MYH7 | Dilated cardiomyopathy (DCM) |
| HP:0032340 | 0.0016781848244 | 0.666666666667 | TPM2 MYH7 | Abnormal spirometry test |
| HP:0001376 | 0.00217170365104 | 1.0 | TPM2 MYH3 MYH7 | Limitation of joint mobility |
| HP:0003687 | 0.00223433522771 | 0.666666666667 | TPM2 MYH7 | Centrally nucleated skeletal muscle fibers |
| HP:0003327 | 0.00223433522771 | 0.666666666667 | TPM2 MYH7 | Axial muscle weakness |
| HP:0008368 | 0.00223433522771 | 0.666666666667 | TPM2 MYH3 | Tarsal synostosis |
| HP:0001373 | 0.00231432739846 | 1.0 | TPM2 MYH3 MYH7 | Joint dislocation |
| HP:0003121 | 0.00236322043956 | 1.0 | TPM2 MYH3 MYH7 | Limb joint contracture |
| HP:0010557 | 0.00243734739233 | 0.666666666667 | TPM2 MYH3 | Overlapping fingers |
| HP:0030878 | 0.00243734739233 | 0.666666666667 | TPM2 MYH7 | Abnormality on pulmonary function testing |
| HP:0002792 | 0.00264917192674 | 0.666666666667 | TPM2 MYH7 | Reduced vital capacity |
| HP:0001883 | 0.00286248042481 | 1.0 | TPM2 MYH3 MYH7 | Talipes |
| HP:0009140 | 0.00286980764378 | 0.666666666667 | TPM2 MYH3 | Synostosis involving bones of the feet |
| HP:0009138 | 0.00286980764378 | 0.666666666667 | TPM2 MYH3 | Synostosis involving bones of the lower limbs |
| HP:0005656 | 0.0029472200921 | 1.0 | TPM2 MYH3 MYH7 | Positional foot deformity |
| HP:0002058 | 0.00309925335629 | 0.666666666667 | TPM2 MYH7 | Myopathic facies |
| HP:0001608 | 0.00342752570631 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the voice |
| KEGG:04261 | 0.00367632825889 | 0.666666666667 | TPM2 MYH7 | Adrenergic signaling in cardiomyocytes |
| HP:0009465 | 0.00384043859485 | 0.666666666667 | TPM2 MYH3 | Ulnar deviation of finger |
| REAC:R-HSA-390522 | 0.00397787610966 | 0.666666666667 | TPM2 MYH3 | Striated Muscle Contraction |
| HP:0009058 | 0.00437859029972 | 0.666666666667 | TPM2 MYH7 | Increased muscle lipid content |
| HP:0001612 | 0.00437859029972 | 0.666666666667 | TPM2 MYH7 | Weak cry |
| HP:0001283 | 0.00466087105439 | 0.666666666667 | TPM2 MYH7 | Bulbar palsy |
| HP:0003273 | 0.00466087105439 | 0.666666666667 | TPM2 MYH3 | Hip contracture |
| HP:0003272 | 0.0046930416058 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the hip bone |
| HP:0001838 | 0.00495195349433 | 0.666666666667 | TPM2 MYH3 | Rocker bottom foot |
| HP:0009810 | 0.00509281251216 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of upper limb joint |
| HP:0008365 | 0.00525183643236 | 0.666666666667 | TPM2 MYH3 | Abnormality of the talus |
| HP:0002791 | 0.00556051868131 | 0.666666666667 | TPM2 MYH7 | Hypoventilation |
| HP:0025429 | 0.00620427636329 | 0.666666666667 | TPM2 MYH7 | Abnormal cry |
| HP:0003803 | 0.00653934942198 | 0.666666666667 | TPM2 MYH7 | Type 1 muscle fiber predominance |
| HP:0001193 | 0.0068832170429 | 0.666666666667 | TPM2 MYH3 | Ulnar deviation of the hand or of fingers of the hand |
| HP:0000464 | 0.00701989306396 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the neck |
| HP:0100266 | 0.0072358780389 | 0.666666666667 | TPM2 MYH3 | Synostosis of carpals/tarsals |
| HP:0002644 | 0.00738203065189 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of pelvic girdle bone morphology |
| HP:0100295 | 0.0079675754074 | 0.666666666667 | TPM2 MYH7 | Muscle fiber atrophy |
| HP:0001270 | 0.00808721315129 | 1.0 | TPM2 MYH3 MYH7 | Motor delay |
| HP:0003557 | 0.00873443203011 | 0.666666666667 | TPM2 MYH7 | Increased variability in muscle fiber diameter |
| GO:0070252 | 0.00929437307021 | 1.0 | TPM2 MYH3 MYH7 | actin-mediated cell contraction |
| HP:0100491 | 0.00938046670593 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of lower limb joint |
| HP:0000218 | 0.00975564299217 | 1.0 | TPM2 MYH3 MYH7 | High palate |
| HP:0003306 | 0.0108053329976 | 0.666666666667 | TPM2 MYH7 | Spinal rigidity |
| HP:0011463 | 0.0112458624499 | 0.666666666667 | TPM2 MYH7 | Childhood onset |
| HP:0008180 | 0.0116951722183 | 0.666666666667 | TPM2 MYH7 | Mildly elevated creatine kinase |
| HP:0000467 | 0.0116951722183 | 0.666666666667 | TPM2 MYH7 | Neck muscle weakness |
| HP:0012084 | 0.0121532611158 | 0.666666666667 | TPM2 MYH7 | Abnormality of skeletal muscle fiber size |
| HP:0002938 | 0.0130957715491 | 0.666666666667 | TPM2 MYH7 | Lumbar hyperlordosis |
| HP:0006380 | 0.0130957715491 | 0.666666666667 | TPM2 MYH3 | Knee flexion contracture |
| HP:0000508 | 0.0135130087077 | 1.0 | TPM2 MYH3 MYH7 | Ptosis |
| HP:0002987 | 0.0145753509873 | 0.666666666667 | TPM2 MYH3 | Elbow flexion contracture |
| HP:0001430 | 0.0150860897283 | 0.666666666667 | TPM2 MYH7 | Abnormality of the calf musculature |
| HP:0007598 | 0.0150860897283 | 0.666666666667 | TPM2 MYH3 | Bilateral single transverse palmar creases |
| HP:0009027 | 0.0150860897283 | 0.666666666667 | TPM2 MYH7 | Foot dorsiflexor weakness |
| HP:0000347 | 0.0154916190073 | 1.0 | TPM2 MYH3 MYH7 | Micrognathia |
| HP:0001371 | 0.0156647085286 | 1.0 | TPM2 MYH3 MYH7 | Flexion contracture |
| HP:0009118 | 0.0157517346871 | 1.0 | TPM2 MYH3 MYH7 | Aplasia/Hypoplasia of the mandible |
| HP:0009116 | 0.0165495188933 | 1.0 | TPM2 MYH3 MYH7 | Aplasia/Hypoplasia involving bones of the skull |
| HP:0003700 | 0.0166709261154 | 0.666666666667 | TPM2 MYH7 | Generalized amyotrophy |
| HP:0100261 | 0.0170041519362 | 1.0 | TPM2 MYH3 MYH7 | Abnormal tendon morphology |
| GO:0030048 | 0.0170248502613 | 1.0 | TPM2 MYH3 MYH7 | actin filament-based movement |
| HP:0003691 | 0.0183346678183 | 0.666666666667 | TPM2 MYH7 | Scapular winging |
| HP:0001181 | 0.0189067773604 | 0.666666666667 | TPM2 MYH3 | Adducted thumb |
| HP:0001374 | 0.0189067773604 | 0.666666666667 | TPM2 MYH7 | Congenital hip dislocation |
| HP:0003325 | 0.0194876494112 | 0.666666666667 | TPM2 MYH7 | Limb-girdle muscle weakness |
| HP:0001634 | 0.0200772827833 | 0.666666666667 | TPM2 MYH7 | Mitral valve prolapse |
| HP:0009122 | 0.0232373370987 | 1.0 | TPM2 MYH3 MYH7 | Aplasia/hypoplasia affecting bones of the axial skeleton |
| HP:0001611 | 0.0237990042853 | 0.666666666667 | TPM2 MYH3 | Nasal speech |
| HP:0001850 | 0.0244499336669 | 0.666666666667 | TPM2 MYH3 | Abnormality of the tarsal bones |
| HP:0001197 | 0.0246197050455 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of prenatal development or birth |
| GO:0030017 | 0.0248678516681 | 1.0 | TPM2 MYH3 MYH7 | sarcomere |
| HP:0006501 | 0.0251096148725 | 0.666666666667 | TPM2 MYH3 | Aplasia/Hypoplasia of the radius |
| HP:0002747 | 0.0264552280074 | 0.666666666667 | TPM2 MYH7 | Respiratory insufficiency due to muscle weakness |
| HP:0001633 | 0.0271411575623 | 0.666666666667 | TPM2 MYH7 | Abnormal mitral valve morphology |
| HP:0000765 | 0.0278006464462 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the thorax |
| HP:0000465 | 0.0278358341925 | 0.666666666667 | TPM2 MYH3 | Webbed neck |
| HP:0001437 | 0.0307019877242 | 0.666666666667 | TPM2 MYH7 | Abnormality of the musculature of the lower limbs |
| HP:0000277 | 0.0308333096044 | 1.0 | TPM2 MYH3 MYH7 | Abnormality of the mandible |
| HP:0011968 | 0.0323585280482 | 1.0 | TPM2 MYH3 MYH7 | Feeding difficulties |
| HP:0004347 | 0.0329433889933 | 0.666666666667 | TPM2 MYH7 | Weakness of muscles of respiration |
| HP:0002515 | 0.0337079994886 | 0.666666666667 | TPM2 MYH7 | Waddling gait |
| GO:0030016 | 0.0340260876928 | 1.0 | TPM2 MYH3 MYH7 | myofibril |
| HP:0006503 | 0.0344813463748 | 0.666666666667 | TPM2 MYH3 | Aplasia/hypoplasia involving forearm bones |
| HP:0003028 | 0.0344813463748 | 0.666666666667 | TPM2 MYH7 | Abnormality of the ankles |
| GO:0044449 | 0.0356085105614 | 1.0 | TPM2 MYH3 MYH7 | contractile fiber part |
| HP:0030791 | 0.0358591294675 | 1.0 | TPM2 MYH3 MYH7 | Abnormal jaw morphology |
| HP:0001787 | 0.0360542445711 | 0.666666666667 | TPM2 MYH3 | Abnormal delivery |
| HP:0007340 | 0.0360542445711 | 0.666666666667 | TPM2 MYH7 | Lower limb muscle weakness |
| HP:0001508 | 0.036313677034 | 1.0 | TPM2 MYH3 MYH7 | Failure to thrive |
| HP:0001435 | 0.0368537935068 | 0.666666666667 | TPM2 MYH7 | Abnormality of the shoulder girdle musculature |
| HP:0002088 | 0.0377003342294 | 1.0 | TPM2 MYH3 MYH7 | Abnormal lung morphology |
| HP:0003458 | 0.0384790851177 | 0.666666666667 | TPM2 MYH7 | EMG: myopathic abnormalities |
| HP:0002996 | 0.0384790851177 | 0.666666666667 | TPM2 MYH3 | Limited elbow movement |
| HP:0001324 | 0.0392819664422 | 1.0 | TPM2 MYH3 MYH7 | Muscle weakness |
| GO:0043292 | 0.0415322430011 | 1.0 | TPM2 MYH3 MYH7 | contractile fiber |
| HP:0006705 | 0.041834410056 | 0.666666666667 | TPM2 MYH7 | Abnormal atrioventricular valve morphology |
| HP:0000174 | 0.0424077548495 | 1.0 | TPM2 MYH3 MYH7 | Abnormal palate morphology |
| HP:0003324 | 0.044442515366 | 0.666666666667 | TPM2 MYH7 | Generalized muscle weakness |
| HP:0001999 | 0.0448141259844 | 1.0 | TPM2 MYH3 MYH7 | Abnormal facial shape |
| HP:0002650 | 0.0451651492781 | 1.0 | TPM2 MYH3 MYH7 | Scoliosis |
| HP:0002804 | 0.0471291092948 | 0.666666666667 | TPM2 MYH3 | Arthrogryposis multiplex congenita |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MYH7 | TPM2 | 0.966 | 0.876 | Guru fraction |
| TPM2 | MYH3 | 0.959 | 0.863 | Guru fraction |
| MYH7 | MYH3 | 0.016 | 0.159 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06391 has an average edge precision of 0.633 which is ranked 1765 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TPM2 | HuMAP2_02652 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387 HuMAP2_06391 |
| MYH7 | HuMAP2_02064 HuMAP2_06391 |
| MYH3 | HuMAP2_04733 HuMAP2_06061 HuMAP2_06391 |