hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06392
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATG16L1 | Autophagy-related protein 16-1 (APG16-like 1) | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | UniProt NCBI |
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2509 | 9.91919199118e-08 | 1.0 | ATG16L1 ATG3 ATG5 | Nanoparticle triggered autophagic cell death |
| KEGG:04136 | 1.35175330869e-07 | 1.0 | ATG16L1 ATG3 ATG5 | Autophagy - other |
| WP:WP4577 | 7.94887976384e-07 | 1.0 | ATG16L1 ATG3 ATG5 | Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway |
| WP:WP615 | 7.31469557978e-06 | 1.0 | ATG16L1 ATG3 ATG5 | Senescence and Autophagy in Cancer |
| KEGG:04140 | 1.15269222189e-05 | 1.0 | ATG16L1 ATG3 ATG5 | Autophagy - animal |
| REAC:R-HSA-1632852 | 4.7655024582e-05 | 1.0 | ATG16L1 ATG3 ATG5 | Macroautophagy |
| REAC:R-HSA-9612973 | 7.95116633082e-05 | 1.0 | ATG16L1 ATG3 ATG5 | Autophagy |
| GO:0019776 | 0.00405722906526 | 0.666666666667 | ATG5 ATG3 | Atg8 ligase activity |
| KEGG:04621 | 0.00551574183542 | 0.666666666667 | ATG16L1 ATG5 | NOD-like receptor signaling pathway |
| GO:0000045 | 0.00718184217333 | 1.0 | ATG16L1 ATG3 ATG5 | autophagosome assembly |
| GO:1905037 | 0.00746165420606 | 1.0 | ATG16L1 ATG3 ATG5 | autophagosome organization |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | ATG16L1 ATG3 ATG5 | Cellular responses to external stimuli |
| GO:0007033 | 0.033252767518 | 1.0 | ATG16L1 ATG3 ATG5 | vacuole organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATG16L1 | ATG5 | 0.993 | 0.918 | bioplex_WMM Guru Malo fraction |
| ATG5 | ATG3 | 0.543 | 0.644 | bioplex (ATG3) bioplex_WMM |
| ATG16L1 | ATG3 | 0.482 | 0.612 | bioplex (ATG3) bioplex_WMM |
Images
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Complex HuMAP2_06392 has an average edge precision of 0.725 which is ranked 1296 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATG16L1 | HuMAP2_02085 HuMAP2_02846 HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG5 | HuMAP2_02085 HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG3 | HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |