hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06394
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HLA-DOA | HLA class II histocompatibility antigen, DO alpha chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA) | UniProt NCBI |
| HLA-DRA | HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA) | UniProt NCBI |
| HLA-DRB1 | HLA class II histocompatibility antigen, DRB1-3 chain (Clone P2-beta-3) (MHC class II antigen DRB1*3) | UniProt NCBI |
| ITM2A | Integral membrane protein 2A (Protein E25) | UniProt NCBI |
| HLA-DRB5 | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05310 | 8.30209140842e-11 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Asthma |
| KEGG:05330 | 6.94638460279e-10 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Allograft rejection |
| KEGG:05332 | 1.4678841019e-09 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Graft-versus-host disease |
| KEGG:04672 | 1.73467881046e-09 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Intestinal immune network for IgA production |
| KEGG:04940 | 2.75543196072e-09 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Type I diabetes mellitus |
| KEGG:05320 | 6.07249572778e-09 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Autoimmune thyroid disease |
| KEGG:05321 | 1.57362126176e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Inflammatory bowel disease (IBD) |
| KEGG:05416 | 1.89143161183e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Viral myocarditis |
| GO:0042613 | 2.56070819562e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | MHC class II protein complex |
| KEGG:04640 | 3.39277316703e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Hematopoietic cell lineage |
| KEGG:04612 | 3.66399763331e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Antigen processing and presentation |
| WP:WP2328 | 3.82232434208e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Allograft Rejection |
| KEGG:05323 | 4.25486304909e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Rheumatoid arthritis |
| KEGG:05140 | 4.57573824438e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Leishmaniasis |
| KEGG:05150 | 8.34466687695e-08 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Staphylococcus aureus infection |
| KEGG:04658 | 1.12467879664e-07 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Th1 and Th2 cell differentiation |
| GO:0042611 | 2.21856478938e-07 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | MHC protein complex |
| KEGG:04659 | 2.45605145915e-07 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Th17 cell differentiation |
| KEGG:05145 | 3.52545514895e-07 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Toxoplasmosis |
| KEGG:04514 | 4.71838806996e-07 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Cell adhesion molecules (CAMs) |
| REAC:R-HSA-202430 | 5.97663979449e-07 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | Translocation of ZAP-70 to Immunological synapse |
| WP:WP4217 | 6.891143787e-07 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Ebola Virus Pathway on Host |
| KEGG:05322 | 7.43603770459e-07 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Systemic lupus erythematosus |
| REAC:R-HSA-202427 | 1.23570409997e-06 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | Phosphorylation of CD3 and TCR zeta chains |
| KEGG:04145 | 1.52643011028e-06 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Phagosome |
| REAC:R-HSA-389948 | 1.84639431008e-06 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | PD-1 signaling |
| KEGG:05164 | 2.21211194343e-06 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Influenza A |
| KEGG:05152 | 2.33516050441e-06 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Tuberculosis |
| REAC:R-HSA-2132295 | 2.59920773791e-06 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | MHC class II antigen presentation |
| KEGG:05169 | 5.20183927819e-06 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Epstein-Barr virus infection |
| REAC:R-HSA-202433 | 6.24012216224e-06 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | Generation of second messenger molecules |
| KEGG:05166 | 6.99700274835e-06 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Human T-cell leukemia virus 1 infection |
| GO:0032395 | 3.17736949706e-05 | 0.6 | HLA-DRB1 HLA-DRA HLA-DOA | MHC class II receptor activity |
| REAC:R-HSA-388841 | 6.70990066737e-05 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | Costimulation by the CD28 family |
| KEGG:05168 | 9.63165855874e-05 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Herpes simplex virus 1 infection |
| WP:WP530 | 0.00015011307213 | 0.4 | HLA-DRB1 HLA-DRA | Cytokines and Inflammatory Response |
| REAC:R-HSA-877300 | 0.00018227939524 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | Interferon gamma signaling |
| GO:0019886 | 0.000296464073962 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| REAC:R-HSA-202424 | 0.000306125075711 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | Downstream TCR signaling |
| GO:0002495 | 0.000310236355112 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 0.000324482580121 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| GO:0023026 | 0.000330213415772 | 0.6 | HLA-DRB1 HLA-DRA HLA-DOA | MHC class II protein complex binding |
| GO:0023023 | 0.000412725169389 | 0.6 | HLA-DRB1 HLA-DRA HLA-DOA | MHC protein complex binding |
| REAC:R-HSA-202403 | 0.000534065976599 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | TCR signaling |
| GO:0042605 | 0.000878614215261 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | peptide antigen binding |
| GO:0098553 | 0.00160515829483 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | lumenal side of endoplasmic reticulum membrane |
| GO:0071556 | 0.00160515829483 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | integral component of lumenal side of endoplasmic reticulum membrane |
| REAC:R-HSA-913531 | 0.00230616063943 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | Interferon Signaling |
| REAC:R-HSA-1280218 | 0.00256626643698 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | Adaptive Immune System |
| GO:0098576 | 0.00265002518516 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | lumenal side of membrane |
| GO:0030669 | 0.00330982532021 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | clathrin-coated endocytic vesicle membrane |
| GO:0002478 | 0.00342761547193 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | antigen processing and presentation of exogenous peptide antigen |
| GO:0019884 | 0.00360020272665 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | antigen processing and presentation of exogenous antigen |
| GO:0048002 | 0.00435640040345 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | antigen processing and presentation of peptide antigen |
| GO:0003823 | 0.00541762673764 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | antigen binding |
| GO:0042277 | 0.00705155239441 | 0.8 | HLA-DRB1 ITM2A HLA-DRA HLA-DRB5 | peptide binding |
| GO:0019882 | 0.00705155239441 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | antigen processing and presentation |
| GO:0045334 | 0.0103850554114 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | clathrin-coated endocytic vesicle |
| GO:0012507 | 0.0128326937391 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | ER to Golgi transport vesicle membrane |
| GO:0033218 | 0.013214868117 | 0.8 | HLA-DRB1 ITM2A HLA-DRA HLA-DRB5 | amide binding |
| GO:0031902 | 0.0237016209836 | 0.6 | HLA-DRB1 HLA-DRA HLA-DRB5 | late endosome membrane |
| GO:0098852 | 0.023793677699 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | lytic vacuole membrane |
| GO:0005765 | 0.023793677699 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | lysosomal membrane |
| GO:0005774 | 0.0397074972468 | 0.8 | HLA-DOA HLA-DRB1 HLA-DRA HLA-DRB5 | vacuolar membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HLA-DRB1 | 100294276 | 0.97 | 0.881 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRB1 | HLA-DRB5 | 0.954 | 0.861 | bioplex (HLA-DRB1) bioplex_WMM |
| HLA-DRA | HLA-DRB5 | 0.058 | 0.325 | bioplex (HLA-DRA) bioplex_WMM |
| HLA-DRB1 | HLA-DOA | 0.028 | 0.229 | bioplex (HLA-DRB1) bioplex_WMM |
| ITM2A | HLA-DOA | 0.02 | 0.186 | bioplex (ITM2A) bioplex_WMM |
| HLA-DRB5 | 100294276 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| HLA-DOA | 100294276 | 0.009 | 0.092 | bioplex_WMM WMM_only |
| HLA-DRB5 | HLA-DOA | 0.008 | 0.026 | bioplex_WMM WMM_only |
| ITM2A | 100294276 | 0.007 | 0.001 | bioplex (ITM2A) bioplex_WMM |
| ITM2A | HLA-DRB1 | 0.006 | 0.008 | bioplex (ITM2A) bioplex_WMM |
| HLA-DRA | HLA-DRB1 | 0.006 | 0.007 | bioplex (HLA-DRA) bioplex_WMM |
| HLA-DRA | 100294276 | 0.003 | 0.012 | bioplex (HLA-DRA) bioplex_WMM |
Images
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Complex HuMAP2_06394 has an average edge precision of 0.227 which is ranked 5745 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HLA-DOA | HuMAP2_00757 HuMAP2_04434 HuMAP2_06394 |
| HLA-DRA | HuMAP2_00757 HuMAP2_03879 HuMAP2_06394 |
| HLA-DRB1 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |
| ITM2A | HuMAP2_00306 HuMAP2_00917 HuMAP2_06394 |
| HLA-DRB5 | HuMAP2_00757 HuMAP2_03879 HuMAP2_04315 HuMAP2_06394 |