hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06395
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HOXC9 | Homeobox protein Hox-C9 (Homeobox protein Hox-3B) | UniProt NCBI |
| DLG3 | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | UniProt NCBI |
| DLG1 | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | UniProt NCBI |
| IDE | Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-447038 | 0.000211071833435 | 0.5 | DLG3 DLG1 | NrCAM interactions |
| REAC:R-HSA-451308 | 0.000361772624521 | 0.5 | DLG3 DLG1 | Activation of Ca-permeable Kainate Receptor |
| REAC:R-HSA-451306 | 0.000361772624521 | 0.5 | DLG3 DLG1 | Ionotropic activity of kainate receptors |
| REAC:R-HSA-442982 | 0.00153629461685 | 0.5 | DLG3 DLG1 | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 0.00171688133139 | 0.5 | DLG3 DLG1 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.00171688133139 | 0.5 | DLG3 DLG1 | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 0.0019074750117 | 0.5 | DLG3 DLG1 | Long-term potentiation |
| REAC:R-HSA-8849932 | 0.0019074750117 | 0.5 | DLG3 DLG1 | Synaptic adhesion-like molecules |
| REAC:R-HSA-442742 | 0.00326103241616 | 0.5 | DLG3 DLG1 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-451326 | 0.00352159938331 | 0.5 | DLG3 DLG1 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-9609736 | 0.0070462802506 | 0.5 | DLG3 DLG1 | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04390 | 0.0198080875546 | 0.5 | DLG3 DLG1 | Hippo signaling pathway |
| KEGG:04530 | 0.0206513420529 | 0.5 | DLG3 DLG1 | Tight junction |
| REAC:R-HSA-438064 | 0.0262582706021 | 0.5 | DLG3 DLG1 | Post NMDA receptor activation events |
| REAC:R-HSA-6794362 | 0.0323499619092 | 0.5 | DLG3 DLG1 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.0347967852364 | 0.5 | DLG3 DLG1 | Activation of NMDA receptors and postsynaptic events |
| CORUM:3209 | 0.0499140284799 | 0.25 | DLG1 | LIN2-SAP97 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DLG1 | IDE | 0.122 | 0.394 | fraction |
| DLG1 | DLG3 | 0.082 | 0.351 | hein_WMM hein (DLG3) gupta_WMM |
| HOXC9 | IDE | 0.05 | 0.298 | bioplex (HOXC9) bioplex_WMM |
| IDE | DLG3 | 0.028 | 0.232 | fraction |
Images
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Complex HuMAP2_06395 has an average edge precision of 0.319 which is ranked 4358 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HOXC9 | HuMAP2_00641 HuMAP2_03107 HuMAP2_06395 HuMAP2_07016 |
| DLG3 | HuMAP2_03840 HuMAP2_06051 HuMAP2_06395 |
| DLG1 | HuMAP2_03001 HuMAP2_03840 HuMAP2_06395 |
| IDE | HuMAP2_03107 HuMAP2_06395 |