hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06404
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC8A1 | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | UniProt NCBI |
| ACVRL1 | Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I) | UniProt NCBI |
| ACVR1 | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | UniProt NCBI |
| BMPR2 | Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0017002 | 2.03382379613e-05 | 0.75 | ACVRL1 ACVR1 BMPR2 | activin-activated receptor activity |
| GO:0005024 | 5.99161085695e-05 | 0.75 | ACVRL1 ACVR1 BMPR2 | transforming growth factor beta-activated receptor activity |
| GO:0004675 | 0.000165189908538 | 0.75 | ACVRL1 ACVR1 BMPR2 | transmembrane receptor protein serine/threonine kinase activity |
| KEGG:04060 | 0.000178844685022 | 0.75 | ACVRL1 ACVR1 BMPR2 | Cytokine-cytokine receptor interaction |
| GO:0030501 | 0.00106129291317 | 0.75 | SLC8A1 ACVR1 BMPR2 | positive regulation of bone mineralization |
| GO:0003197 | 0.00147288799354 | 0.75 | ACVRL1 ACVR1 BMPR2 | endocardial cushion development |
| GO:0110151 | 0.00163061517788 | 0.75 | SLC8A1 ACVR1 BMPR2 | positive regulation of biomineralization |
| GO:0070169 | 0.00163061517788 | 0.75 | SLC8A1 ACVR1 BMPR2 | positive regulation of biomineral tissue development |
| REAC:R-HSA-201451 | 0.00253927088831 | 0.5 | ACVRL1 BMPR2 | Signaling by BMP |
| GO:0010862 | 0.00331394418715 | 0.75 | ACVRL1 ACVR1 BMPR2 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0007507 | 0.00468073964129 | 1.0 | SLC8A1 BMPR2 ACVR1 ACVRL1 | heart development |
| GO:0030500 | 0.00480126971785 | 0.75 | SLC8A1 ACVR1 BMPR2 | regulation of bone mineralization |
| GO:0045778 | 0.00587743889796 | 0.75 | SLC8A1 ACVR1 BMPR2 | positive regulation of ossification |
| KEGG:04350 | 0.00597612422935 | 0.5 | ACVR1 BMPR2 | TGF-beta signaling pathway |
| GO:0060393 | 0.0062689516986 | 0.75 | ACVRL1 ACVR1 BMPR2 | regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0060389 | 0.00754689803038 | 0.75 | ACVRL1 ACVR1 BMPR2 | pathway-restricted SMAD protein phosphorylation |
| WP:WP3931 | 0.00791698216111 | 0.5 | ACVR1 BMPR2 | ESC Pluripotency Pathways |
| GO:0070724 | 0.00811409485621 | 0.5 | ACVRL1 ACVR1 | BMP receptor complex |
| GO:0110149 | 0.0106004966657 | 0.75 | SLC8A1 ACVR1 BMPR2 | regulation of biomineralization |
| GO:0070167 | 0.0106004966657 | 0.75 | SLC8A1 ACVR1 BMPR2 | regulation of biomineral tissue development |
| GO:0030282 | 0.0111781410126 | 0.75 | SLC8A1 ACVR1 BMPR2 | bone mineralization |
| WP:WP2857 | 0.0137135792553 | 0.5 | ACVR1 BMPR2 | Mesodermal Commitment Pathway |
| KEGG:04550 | 0.0148710843718 | 0.5 | ACVR1 BMPR2 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:05418 | 0.0153578793248 | 0.5 | ACVR1 BMPR2 | Fluid shear stress and atherosclerosis |
| GO:0016361 | 0.0162267366884 | 0.5 | ACVRL1 ACVR1 | activin receptor activity, type I |
| GO:0045446 | 0.017346559408 | 0.75 | ACVRL1 ACVR1 BMPR2 | endothelial cell differentiation |
| GO:0090100 | 0.0206918321066 | 0.75 | ACVRL1 ACVR1 BMPR2 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| GO:0019199 | 0.0206918321066 | 0.75 | ACVRL1 ACVR1 BMPR2 | transmembrane receptor protein kinase activity |
| GO:0110148 | 0.0244411426287 | 0.75 | SLC8A1 ACVR1 BMPR2 | biomineralization |
| GO:0031214 | 0.0244411426287 | 0.75 | SLC8A1 ACVR1 BMPR2 | biomineral tissue development |
| GO:0098821 | 0.0270421395626 | 0.5 | ACVRL1 BMPR2 | BMP receptor activity |
| GO:0005025 | 0.0270421395626 | 0.5 | ACVRL1 ACVR1 | transforming growth factor beta receptor activity, type I |
| GO:0003158 | 0.0275320606423 | 0.75 | ACVRL1 ACVR1 BMPR2 | endothelium development |
| GO:0019955 | 0.0357324157151 | 0.75 | ACVRL1 ACVR1 BMPR2 | cytokine binding |
| REAC:R-HSA-9006936 | 0.0390714342086 | 0.5 | ACVRL1 BMPR2 | Signaling by TGF-beta family members |
| GO:0030509 | 0.0454154921687 | 0.75 | ACVRL1 ACVR1 BMPR2 | BMP signaling pathway |
| GO:0030278 | 0.0484715579516 | 0.75 | SLC8A1 ACVR1 BMPR2 | regulation of ossification |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACVR1 | ACVRL1 | 0.147 | 0.408 | bioplex (ACVR1) bioplex_WMM |
| ACVR1 | SLC8A1 | 0.113 | 0.383 | bioplex (ACVR1) bioplex_WMM |
| ACVR1 | BMPR2 | 0.032 | 0.243 | bioplex (ACVR1) bioplex_WMM |
| SLC8A1 | ACVRL1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| BMPR2 | SLC8A1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| BMPR2 | ACVRL1 | 0.008 | 0.034 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06404 has an average edge precision of 0.204 which is ranked 6125 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLC8A1 | HuMAP2_06404 HuMAP2_06882 |
| ACVRL1 | HuMAP2_06404 HuMAP2_06882 |
| ACVR1 | HuMAP2_01093 HuMAP2_05210 HuMAP2_06404 HuMAP2_06882 |
| BMPR2 | HuMAP2_06090 HuMAP2_06404 |