hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06405
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS51 | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | UniProt NCBI |
| VPS50 | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | UniProt NCBI |
| VPS53 | Vacuolar protein sorting-associated protein 53 homolog | UniProt NCBI |
| VPS52 | Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) | UniProt NCBI |
| EIPR1 | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | UniProt NCBI |
| VPS54 | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | UniProt NCBI |
| SNAP29 | Synaptosomal-associated protein 29 (SNAP-29) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) | UniProt NCBI |
| DHH | Desert hedgehog protein (DHH) (HHG-3) [Cleaved into: Desert hedgehog protein N-product; Desert hedgehog protein C-product] | UniProt NCBI |
| PPFIBP2 | Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) | UniProt NCBI |
| CRABP2 | Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990745 | 2.06436583637e-12 | 0.5 | VPS51 VPS53 VPS50 VPS52 EIPR1 | EARP complex |
| GO:0000938 | 2.06436583637e-12 | 0.5 | VPS51 VPS53 VPS54 VPS52 EIPR1 | GARP complex |
| CORUM:6459 | 7.6236129225e-12 | 0.4 | VPS51 VPS53 VPS52 VPS50 | EARP complex |
| CORUM:6463 | 7.6236129225e-12 | 0.4 | VPS53 VPS54 VPS52 VPS51 | GARP complex |
| GO:0032456 | 1.34511639873e-06 | 0.5 | VPS51 VPS53 VPS50 VPS52 EIPR1 | endocytic recycling |
| REAC:R-HSA-6811440 | 3.77064335825e-06 | 0.4 | VPS53 VPS54 VPS52 VPS51 | Retrograde transport at the Trans-Golgi-Network |
| GO:0099023 | 7.77359969235e-06 | 0.5 | VPS51 VPS53 VPS54 VPS52 EIPR1 | vesicle tethering complex |
| REAC:R-HSA-6811442 | 1.92253428427e-05 | 0.5 | VPS51 SNAP29 VPS54 VPS52 VPS53 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0042147 | 5.17770793949e-05 | 0.5 | VPS51 VPS53 VPS54 VPS52 EIPR1 | retrograde transport, endosome to Golgi |
| GO:0016197 | 5.46206823907e-05 | 0.6 | EIPR1 VPS51 VPS54 VPS50 VPS53 VPS52 | endosomal transport |
| GO:0055037 | 0.000365157328034 | 0.5 | VPS51 VPS53 VPS50 VPS52 EIPR1 | recycling endosome |
| GO:0016482 | 0.000922062076289 | 0.5 | VPS51 VPS53 VPS54 VPS52 EIPR1 | cytosolic transport |
| REAC:R-HSA-199991 | 0.0039770933691 | 0.5 | VPS51 SNAP29 VPS54 VPS52 VPS53 | Membrane Trafficking |
| GO:0005802 | 0.00447950174562 | 0.5 | VPS51 VPS53 VPS54 VPS52 EIPR1 | trans-Golgi network |
| REAC:R-HSA-5653656 | 0.00515671601154 | 0.5 | VPS51 SNAP29 VPS54 VPS52 VPS53 | Vesicle-mediated transport |
| GO:0032588 | 0.00873765883955 | 0.4 | VPS53 VPS54 VPS52 VPS51 | trans-Golgi network membrane |
| GO:0098791 | 0.0106109309713 | 0.5 | VPS51 VPS53 VPS54 VPS52 EIPR1 | Golgi subcompartment |
| GO:0007041 | 0.0116266718166 | 0.4 | VPS53 VPS54 VPS52 VPS51 | lysosomal transport |
| GO:0000149 | 0.0121698708739 | 0.4 | SNAP29 VPS54 VPS52 VPS50 | SNARE binding |
| GO:0031984 | 0.0159811657643 | 0.5 | VPS51 VPS53 VPS54 VPS52 EIPR1 | organelle subcompartment |
| GO:0007034 | 0.0307271341994 | 0.4 | VPS53 VPS54 VPS52 VPS51 | vacuolar transport |
| GO:0044431 | 0.0381232986928 | 0.6 | VPS51 SNAP29 VPS54 VPS53 EIPR1 VPS52 | Golgi apparatus part |
| GO:0044433 | 0.0400218923003 | 0.7 | VPS51 SNAP29 VPS54 VPS53 VPS50 EIPR1 VPS52 | cytoplasmic vesicle part |
| GO:0044440 | 0.0466129813419 | 0.5 | VPS51 VPS53 VPS50 VPS52 EIPR1 | endosomal part |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS53 | VPS50 | 1.0 | 0.949 | hein_WMM bioplex (VPS50,VPS53) bioplex_WMM boldt youn_WMM hein (VPS50) Malo fraction boldt_WMM |
| VPS50 | EIPR1 | 1.0 | 0.949 | hein_WMM bioplex (EIPR1,VPS50) bioplex_WMM boldt hein (VPS50) boldt_WMM |
| VPS50 | VPS51 | 1.0 | 0.949 | hein_WMM bioplex (VPS50) bioplex_WMM boldt youn_WMM hein (VPS50) Malo fraction boldt_WMM |
| VPS53 | EIPR1 | 0.999 | 0.949 | hein_WMM bioplex (EIPR1) bioplex_WMM boldt fraction boldt_WMM |
| EIPR1 | VPS51 | 0.993 | 0.918 | hein_WMM bioplex (EIPR1) bioplex_WMM boldt fraction boldt_WMM |
| VPS52 | VPS50 | 0.968 | 0.88 | hein_WMM bioplex (VPS50) bioplex_WMM youn_WMM hein (VPS50) |
| VPS54 | EIPR1 | 0.941 | 0.853 | bioplex (EIPR1) bioplex_WMM |
| VPS52 | EIPR1 | 0.87 | 0.804 | hein_WMM bioplex (EIPR1) bioplex_WMM boldt boldt_WMM |
| VPS53 | VPS54 | 0.333 | 0.525 | bioplex (VPS53) bioplex_WMM |
| SNAP29 | PPFIBP2 | 0.287 | 0.489 | bioplex (SNAP29) bioplex_WMM |
| EIPR1 | SNAP29 | 0.23 | 0.468 | hein_WMM bioplex (EIPR1,SNAP29) bioplex_WMM boldt hein (SNAP29) boldt_WMM |
| VPS54 | VPS50 | 0.192 | 0.445 | bioplex (VPS50) bioplex_WMM gupta_WMM |
| VPS51 | SNAP29 | 0.169 | 0.426 | bioplex (SNAP29) bioplex_WMM boldt youn_WMM boldt_WMM |
| VPS50 | CRABP2 | 0.06 | 0.334 | hein_WMM hein (VPS50) |
| VPS50 | SNAP29 | 0.034 | 0.261 | bioplex (SNAP29) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DHH | EIPR1 | 0.022 | 0.204 | bioplex (DHH) bioplex_WMM |
| VPS53 | SNAP29 | 0.015 | 0.148 | bioplex (SNAP29,VPS53) bioplex_WMM boldt youn_WMM boldt_WMM |
| VPS52 | VPS51 | 0.013 | 0.143 | hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM |
| VPS53 | VPS52 | 0.012 | 0.153 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| VPS54 | VPS51 | 0.009 | 0.109 | bioplex_WMM youn_WMM WMM_only |
| VPS52 | VPS54 | 0.009 | 0.103 | bioplex_WMM WMM_only |
| VPS53 | CRABP2 | 0.008 | 0.083 | hein_WMM WMM_only |
| VPS52 | CRABP2 | 0.008 | 0.083 | hein_WMM WMM_only |
| EIPR1 | PPFIBP2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| VPS50 | PPFIBP2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| EIPR1 | CRABP2 | 0.008 | 0.062 | hein_WMM WMM_only |
| VPS51 | PPFIBP2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| VPS53 | PPFIBP2 | 0.008 | 0.049 | bioplex_WMM WMM_only |
| VPS51 | CRABP2 | 0.008 | 0.034 | hein_WMM WMM_only |
| VPS54 | SNAP29 | 0.007 | 0.004 | bioplex_WMM gupta_WMM WMM_only |
| VPS52 | SNAP29 | 0.006 | 0.005 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DHH | VPS52 | 0.003 | 0.013 | bioplex (DHH) bioplex_WMM |
| DHH | VPS51 | 0.003 | 0.012 | bioplex (DHH) bioplex_WMM |
| DHH | VPS53 | 0.003 | 0.013 | bioplex (DHH) bioplex_WMM |
| DHH | VPS50 | 0.003 | 0.02 | bioplex (DHH) bioplex_WMM |
| VPS53 | VPS51 | 0.0 | 0.003 | hein_WMM bioplex_WMM boldt youn_WMM Malo fraction boldt_WMM |
Images
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Complex HuMAP2_06405 has an average edge precision of 0.324 which is ranked 4292 out of all 6965 complexes.
Related Complexes