hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06430
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MVB12A | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | UniProt NCBI |
| VPS37C | Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C) | UniProt NCBI |
| UBAP1 | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | UniProt NCBI |
| VPS37A | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | UniProt NCBI |
| VPS28 | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | UniProt NCBI |
| VPS37B | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | UniProt NCBI |
| TSG101 | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | UniProt NCBI |
| SEC24B | Protein transport protein Sec24B (SEC24-related protein B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-174495 | 1.51057732359e-19 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| REAC:R-HSA-174490 | 1.51057732359e-19 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Membrane binding and targetting of GAG proteins |
| GO:0000813 | 4.46966480611e-19 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | ESCRT I complex |
| REAC:R-HSA-175474 | 5.03466559592e-19 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Assembly Of The HIV Virion |
| REAC:R-HSA-9615710 | 3.90563106103e-17 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Microautophagy |
| REAC:R-HSA-162588 | 5.20720164407e-17 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 1.15623710884e-16 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0043162 | 9.61845477129e-16 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0036452 | 5.9626307868e-15 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | ESCRT complex |
| REAC:R-HSA-9612973 | 8.67517392625e-13 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Autophagy |
| GO:0075733 | 2.19301728846e-12 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | intracellular transport of virus |
| GO:0046794 | 3.2732826498e-12 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | transport of virus |
| GO:0039702 | 5.00715728072e-12 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | viral budding via host ESCRT complex |
| REAC:R-HSA-162599 | 5.43699862893e-12 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 1.05885389445e-11 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | HIV Life Cycle |
| GO:1902579 | 1.33480579567e-11 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | multi-organism localization |
| GO:0044766 | 1.33480579567e-11 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | multi-organism transport |
| GO:0046755 | 1.63341960744e-11 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | viral budding |
| GO:0036258 | 5.47331906216e-11 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | multivesicular body assembly |
| GO:0036257 | 6.7861330958e-11 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | multivesicular body organization |
| REAC:R-HSA-162906 | 2.15093880142e-10 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | HIV Infection |
| GO:0019068 | 3.00431142893e-10 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | virion assembly |
| REAC:R-HSA-199991 | 9.0747621596e-10 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | Membrane Trafficking |
| REAC:R-HSA-5653656 | 1.39704957882e-09 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | Vesicle-mediated transport |
| CORUM:1192 | 4.70911134935e-09 | 0.375 | VPS28 VPS37C TSG101 | ESCRT-I complex |
| CORUM:1863 | 4.70911134935e-09 | 0.375 | VPS28 VPS37B TSG101 | TSG101-VPS37B-VPS28 complex |
| REAC:R-HSA-5663205 | 6.07911979864e-09 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Infectious disease |
| GO:0007032 | 1.20303755307e-08 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | endosome organization |
| KEGG:04144 | 1.7115303656e-08 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | Endocytosis |
| GO:0016197 | 2.80378800322e-08 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | endosomal transport |
| GO:0019058 | 9.05914550983e-08 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | viral life cycle |
| GO:0016050 | 2.22594050537e-07 | 0.875 | VPS37A SEC24B VPS37C VPS28 TSG101 MVB12A VPS37B | vesicle organization |
| GO:0010008 | 2.67053120963e-07 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | endosome membrane |
| GO:0044440 | 6.80682745504e-07 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | endosomal part |
| REAC:R-HSA-1643685 | 5.59548960867e-06 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | Disease |
| GO:0098796 | 6.33514220609e-06 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | membrane protein complex |
| GO:0016032 | 6.74344260206e-06 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | viral process |
| GO:0044403 | 1.32616080196e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | symbiotic process |
| GO:0006511 | 1.42637039189e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 1.51113867297e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | modification-dependent protein catabolic process |
| GO:0043632 | 1.76683488799e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | modification-dependent macromolecule catabolic process |
| GO:0044419 | 1.94812476105e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | interspecies interaction between organisms |
| GO:0044433 | 2.79859045401e-05 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | cytoplasmic vesicle part |
| GO:0016236 | 3.30913875777e-05 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | macroautophagy |
| GO:0098805 | 4.29128396404e-05 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | whole membrane |
| GO:0051603 | 4.59931208891e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | proteolysis involved in cellular protein catabolic process |
| GO:0007034 | 6.04437816709e-05 | 0.625 | VPS28 VPS37A MVB12A VPS37B VPS37C | vacuolar transport |
| GO:0005768 | 7.13246416286e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | endosome |
| GO:0044257 | 8.55147748663e-05 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | cellular protein catabolic process |
| GO:0072666 | 0.000154861828642 | 0.5 | VPS28 VPS37A VPS37B VPS37C | establishment of protein localization to vacuole |
| GO:0010256 | 0.000161059380622 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | endomembrane system organization |
| GO:0098588 | 0.000211856125423 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | bounding membrane of organelle |
| GO:0030163 | 0.000250787237937 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | protein catabolic process |
| GO:0046907 | 0.000346824278428 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | intracellular transport |
| GO:0006914 | 0.000448581094574 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | autophagy |
| GO:0061919 | 0.000448581094574 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | process utilizing autophagic mechanism |
| GO:0072665 | 0.000534279096056 | 0.5 | VPS28 VPS37A VPS37B VPS37C | protein localization to vacuole |
| GO:0016192 | 0.00066641542434 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | vesicle-mediated transport |
| GO:0031410 | 0.000694554370642 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | cytoplasmic vesicle |
| GO:0097708 | 0.000698143798914 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | intracellular vesicle |
| GO:0043130 | 0.00145578706246 | 0.5 | VPS28 UBAP1 MVB12A TSG101 | ubiquitin binding |
| GO:0044265 | 0.00181145261579 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | cellular macromolecule catabolic process |
| GO:0051649 | 0.00181553402649 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | establishment of localization in cell |
| GO:1901565 | 0.00243447233413 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | organonitrogen compound catabolic process |
| GO:0032182 | 0.00373379969889 | 0.5 | VPS28 UBAP1 MVB12A TSG101 | ubiquitin-like protein binding |
| GO:0009057 | 0.00551287161027 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | macromolecule catabolic process |
| GO:0006508 | 0.00952033788181 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | proteolysis |
| GO:0070925 | 0.0111731156143 | 0.75 | VPS37A VPS37C VPS28 TSG101 MVB12A VPS37B | organelle assembly |
| GO:0031090 | 0.0160038940184 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | organelle membrane |
| GO:0051641 | 0.0161157357033 | 1.0 | VPS37A UBAP1 SEC24B VPS37C VPS28 MVB12A TSG101 VPS37B | cellular localization |
| GO:0006623 | 0.0250420956031 | 0.375 | VPS37A VPS37B VPS37C | protein targeting to vacuole |
| GO:0051704 | 0.0356536253492 | 0.875 | VPS37A UBAP1 VPS37C VPS28 MVB12A TSG101 VPS37B | multi-organism process |
| GO:1903774 | 0.0378589948753 | 0.25 | TSG101 VPS37B | positive regulation of viral budding via host ESCRT complex |
| CORUM:7139 | 0.0497224828424 | 0.125 | SEC24B | SEC23-SEC24 adaptor complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS37B | VPS28 | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM Guru youn_WMM hein (VPS28) Malo fraction |
| VPS28 | VPS37A | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM hein (VPS28) |
| MVB12A | VPS28 | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM hein (VPS28) Malo fraction |
| TSG101 | VPS28 | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM Guru youn_WMM hein (TSG101,VPS28) Malo gupta_WMM fraction |
| VPS37B | TSG101 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) Malo fraction |
| TSG101 | UBAP1 | 1.0 | 0.949 | hein_WMM bioplex (UBAP1) bioplex_WMM youn_WMM hein (TSG101) Malo fraction |
| VPS28 | UBAP1 | 1.0 | 0.949 | hein_WMM bioplex (UBAP1,VPS28) bioplex_WMM hein (VPS28) |
| MVB12A | TSG101 | 0.996 | 0.927 | hein_WMM bioplex_WMM hein (TSG101) Malo fraction |
| TSG101 | VPS37C | 0.987 | 0.902 | hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) fraction |
| UBAP1 | VPS37A | 0.919 | 0.841 | hein_WMM bioplex (UBAP1) bioplex_WMM youn_WMM |
| MVB12A | VPS37B | 0.509 | 0.629 | hein_WMM bioplex_WMM Malo fraction |
| VPS37C | VPS28 | 0.404 | 0.564 | hein_WMM bioplex (VPS28) bioplex_WMM youn_WMM hein (VPS28) |
| TSG101 | VPS37A | 0.211 | 0.459 | hein_WMM bioplex_WMM youn_WMM hein (TSG101) |
| VPS37B | UBAP1 | 0.152 | 0.409 | hein_WMM bioplex (UBAP1) bioplex_WMM |
| SEC24B | VPS37B | 0.066 | 0.348 | youn_WMM fraction |
| SEC24B | TSG101 | 0.051 | 0.296 | bioplex_WMM youn_WMM fraction |
| VPS37B | VPS37A | 0.015 | 0.14 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MVB12A | VPS37C | 0.012 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| MVB12A | UBAP1 | 0.01 | 0.105 | hein_WMM bioplex_WMM WMM_only |
| MVB12A | VPS37A | 0.009 | 0.11 | hein_WMM bioplex_WMM WMM_only |
| VPS37C | UBAP1 | 0.009 | 0.107 | hein_WMM bioplex_WMM WMM_only |
| VPS37B | VPS37C | 0.009 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| VPS37C | VPS37A | 0.009 | 0.09 | hein_WMM bioplex_WMM WMM_only |
| SEC24B | VPS37A | 0.007 | 0.004 | youn_WMM WMM_only |
| SEC24B | VPS28 | 0.007 | 0.004 | youn_WMM gupta_WMM WMM_only |
| SEC24B | UBAP1 | 0.007 | 0.003 | youn_WMM WMM_only |
| SEC24B | MVB12A | 0.007 | 0.005 | hein_WMM bioplex_WMM WMM_only |
| SEC24B | VPS37C | 0.004 | 0.008 | youn_WMM fraction |
Images
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Complex HuMAP2_06430 has an average edge precision of 0.459 which is ranked 2812 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MVB12A | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_05381 HuMAP2_05909 HuMAP2_06430 |
| VPS37C | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 HuMAP2_06935 |
| UBAP1 | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS37A | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS28 | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS37B | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| TSG101 | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| SEC24B | HuMAP2_00758 HuMAP2_02057 HuMAP2_05176 HuMAP2_06134 HuMAP2_06430 |