hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06435
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ILK | Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK) | UniProt NCBI |
| LIMS1 | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | UniProt NCBI |
| PARVB | Beta-parvin (Affixin) | UniProt NCBI |
| PARVA | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | UniProt NCBI |
| RSU1 | Ras suppressor protein 1 (RSP-1) (Rsu-1) | UniProt NCBI |
| PARVG | Gamma-parvin | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446353 | 1.37975151879e-12 | 0.833333333333 | LIMS1 PARVB RSU1 ILK PARVA | Cell-extracellular matrix interactions |
| REAC:R-HSA-446388 | 8.39486242387e-11 | 0.666666666667 | LIMS1 PARVB RSU1 PARVA | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
| REAC:R-HSA-446728 | 2.09044250377e-09 | 0.833333333333 | LIMS1 PARVB RSU1 ILK PARVA | Cell junction organization |
| CORUM:6919 | 2.25356268047e-09 | 0.5 | PARVA ILK LIMS1 | ILK-LIMS1-PARVA complex |
| REAC:R-HSA-1500931 | 1.4030126133e-08 | 0.833333333333 | LIMS1 PARVB RSU1 ILK PARVA | Cell-Cell communication |
| GO:0031589 | 6.35556736442e-07 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | cell-substrate adhesion |
| GO:0034446 | 1.17664441353e-06 | 0.833333333333 | LIMS1 PARVB PARVA ILK PARVG | substrate adhesion-dependent cell spreading |
| GO:0005925 | 8.64690256218e-06 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | focal adhesion |
| GO:0005924 | 8.94634093989e-06 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | cell-substrate adherens junction |
| GO:0030055 | 9.73295551602e-06 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | cell-substrate junction |
| WP:WP306 | 1.49438226774e-05 | 0.666666666667 | PARVB PARVA ILK PARVG | Focal Adhesion |
| KEGG:04510 | 1.71027631169e-05 | 0.666666666667 | PARVB PARVA ILK PARVG | Focal adhesion |
| CORUM:6920 | 2.51655344529e-05 | 0.333333333333 | PARVA ILK | ILK-LIMS2-PARVA complex |
| CORUM:5498 | 2.51655344529e-05 | 0.333333333333 | PARVB ILK | ILK-PARVB-ARHGEF6 complex |
| GO:0005912 | 3.98827060269e-05 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | adherens junction |
| GO:0070161 | 4.60506796006e-05 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | anchoring junction |
| WP:WP2572 | 5.90727924684e-05 | 0.5 | PARVA ILK LIMS1 | Primary Focal Segmental Glomerulosclerosis FSGS |
| REAC:R-HSA-446343 | 0.000132982220163 | 0.333333333333 | PARVA ILK | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| GO:0030054 | 0.000471597995839 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | cell junction |
| GO:0007155 | 0.00196767444467 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | cell adhesion |
| GO:0022610 | 0.00205065811183 | 1.0 | ILK PARVA PARVB RSU1 PARVG LIMS1 | biological adhesion |
| GO:0000904 | 0.00753328148896 | 0.833333333333 | LIMS1 PARVB PARVA ILK PARVG | cell morphogenesis involved in differentiation |
| GO:0000902 | 0.0430733890744 | 0.833333333333 | LIMS1 PARVB PARVA ILK PARVG | cell morphogenesis |
| CORUM:764 | 0.0499726005494 | 0.166666666667 | PARVB | Dysferlin-affixin complex |
| CORUM:4025 | 0.0499726005494 | 0.166666666667 | PARVB | ACTN1-PARVB complex |
| CORUM:5499 | 0.0499726005494 | 0.166666666667 | PARVB | PARVB-ARHGEF6 complex |
| CORUM:6510 | 0.0499726005494 | 0.166666666667 | ILK | ILK-SERCA2A-PLN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ILK | PARVA | 1.0 | 0.949 | hein_WMM bioplex (ILK,PARVA) bioplex_WMM Guru hein (ILK) Malo fraction treiber_WMM |
| ILK | LIMS1 | 1.0 | 0.949 | hein_WMM bioplex (ILK,LIMS1) bioplex_WMM hein (ILK) fraction |
| ILK | PARVB | 1.0 | 0.949 | hein_WMM bioplex (ILK) bioplex_WMM Guru hein (ILK) fraction |
| ILK | RSU1 | 1.0 | 0.949 | hein_WMM bioplex (ILK,RSU1) bioplex_WMM hein (ILK) Malo fraction |
| PARVB | PARVA | 1.0 | 0.949 | hein_WMM bioplex (PARVA) bioplex_WMM |
| RSU1 | PARVB | 0.996 | 0.928 | hein_WMM bioplex (RSU1) bioplex_WMM Guru fraction |
| PARVB | LIMS1 | 0.99 | 0.909 | hein_WMM bioplex (LIMS1) bioplex_WMM fraction |
| ILK | PARVG | 0.986 | 0.9 | bioplex (PARVG) bioplex_WMM |
| RSU1 | LIMS1 | 0.985 | 0.899 | hein_WMM bioplex (LIMS1,RSU1) bioplex_WMM fraction |
| RSU1 | PARVA | 0.979 | 0.895 | hein_WMM bioplex (PARVA,RSU1) bioplex_WMM Guru Malo fraction |
| PARVG | RSU1 | 0.894 | 0.82 | bioplex (PARVG) bioplex_WMM |
| PARVA | LIMS1 | 0.867 | 0.801 | hein_WMM bioplex (LIMS1,PARVA) bioplex_WMM fraction |
| PARVG | LIMS1 | 0.683 | 0.711 | bioplex (PARVG) bioplex_WMM |
Images
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Complex HuMAP2_06435 has an average edge precision of 0.893 which is ranked 613 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ILK | HuMAP2_01374 HuMAP2_02505 HuMAP2_06435 HuMAP2_06595 |
| LIMS1 | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| PARVB | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| PARVA | HuMAP2_01374 HuMAP2_02505 HuMAP2_06435 HuMAP2_06595 |
| RSU1 | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| PARVG | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |