hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06440
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ADGRA3 | Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125) | UniProt NCBI |
| MTG2 | Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5) (Protein obg homolog 1) (ObgH1) | UniProt NCBI |
| STAM | Signal transducing adapter molecule 1 (STAM-1) | UniProt NCBI |
| PREP | Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) | UniProt NCBI |
| HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | UniProt NCBI |
| STAM2 | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0033565 | 1.81637152046e-06 | 0.5 | STAM2 STAM HGS | ESCRT-0 complex |
| REAC:R-HSA-8875360 | 2.16413418261e-06 | 0.5 | STAM2 STAM HGS | InlB-mediated entry of Listeria monocytogenes into host cell |
| REAC:R-HSA-8876384 | 5.75676182894e-06 | 0.5 | STAM2 STAM HGS | Listeria monocytogenes entry into host cells |
| REAC:R-HSA-6807004 | 6.77163692478e-06 | 0.5 | STAM2 STAM HGS | Negative regulation of MET activity |
| REAC:R-HSA-182971 | 1.36517474966e-05 | 0.5 | STAM2 STAM HGS | EGFR downregulation |
| CORUM:3677 | 2.51655344529e-05 | 0.333333333333 | STAM2 HGS | RIN1-STAM2-HRS complex |
| CORUM:7287 | 2.51655344529e-05 | 0.333333333333 | STAM HGS | SIMPLE-HRS-STAM1 complex |
| REAC:R-HSA-917729 | 2.6656058306e-05 | 0.5 | STAM2 STAM HGS | Endosomal Sorting Complex Required For Transport (ESCRT) |
| REAC:R-HSA-177929 | 7.30512953501e-05 | 0.5 | STAM2 STAM HGS | Signaling by EGFR |
| REAC:R-HSA-6806834 | 0.00036649373235 | 0.5 | STAM2 STAM HGS | Signaling by MET |
| REAC:R-HSA-8856825 | 0.000667561375412 | 0.5 | STAM2 STAM HGS | Cargo recognition for clathrin-mediated endocytosis |
| WP:WP437 | 0.000981982556245 | 0.5 | STAM2 STAM HGS | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-8856828 | 0.00204204589337 | 0.5 | STAM2 STAM HGS | Clathrin-mediated endocytosis |
| KEGG:04144 | 0.00329433483006 | 0.5 | STAM2 STAM HGS | Endocytosis |
| GO:0036452 | 0.00416378298645 | 0.5 | STAM2 STAM HGS | ESCRT complex |
| GO:0036258 | 0.00734442516369 | 0.5 | STAM2 STAM HGS | multivesicular body assembly |
| GO:0036257 | 0.00813009778332 | 0.5 | STAM2 STAM HGS | multivesicular body organization |
| GO:0042059 | 0.0152420239566 | 0.5 | STAM2 STAM HGS | negative regulation of epidermal growth factor receptor signaling pathway |
| REAC:R-HSA-5688426 | 0.0177470475827 | 0.5 | STAM2 STAM HGS | Deubiquitination |
| GO:1901185 | 0.0207293189685 | 0.5 | STAM2 STAM HGS | negative regulation of ERBB signaling pathway |
| REAC:R-HSA-5663205 | 0.0427834850779 | 0.5 | STAM2 STAM HGS | Infectious disease |
| KEGG:04630 | 0.0444979624084 | 0.333333333333 | STAM2 STAM | JAK-STAT signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STAM | HGS | 1.0 | 0.949 | bioplex (STAM) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| HGS | STAM2 | 0.988 | 0.901 | Guru youn_WMM Malo gupta_WMM fraction |
| STAM | ADGRA3 | 0.133 | 0.406 | bioplex (STAM) bioplex_WMM |
| STAM | PREP | 0.065 | 0.347 | fraction |
| STAM2 | PREP | 0.049 | 0.293 | fraction |
| MTG2 | PREP | 0.041 | 0.271 | bioplex (MTG2) bioplex_WMM |
| HGS | ADGRA3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| STAM | STAM2 | 0.008 | 0.07 | youn_WMM gupta_WMM WMM_only |
| STAM2 | MTG2 | 0.007 | 0.001 | youn_WMM WMM_only |
| HGS | MTG2 | 0.007 | 0.002 | youn_WMM WMM_only |
| HGS | PREP | 0.005 | 0.005 | fraction |
Images
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Complex HuMAP2_06440 has an average edge precision of 0.303 which is ranked 4532 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ADGRA3 | HuMAP2_02464 HuMAP2_05413 HuMAP2_06440 |
| MTG2 | HuMAP2_03785 HuMAP2_04758 HuMAP2_06440 |
| STAM | HuMAP2_00820 HuMAP2_02464 HuMAP2_04638 HuMAP2_05413 HuMAP2_06440 |
| PREP | HuMAP2_04758 HuMAP2_06440 |
| HGS | HuMAP2_00820 HuMAP2_00893 HuMAP2_02464 HuMAP2_04329 HuMAP2_04638 HuMAP2_05413 HuMAP2_06440 |
| STAM2 | HuMAP2_00820 HuMAP2_04329 HuMAP2_04638 HuMAP2_05413 HuMAP2_06440 |