hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06442
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS26C | Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A) | UniProt NCBI |
| COMMD10 | COMM domain-containing protein 10 | UniProt NCBI |
| COMMD1 | COMM domain-containing protein 1 (Protein Murr1) | UniProt NCBI |
| VPS35L | VPS35 endosomal protein sorting factor-like (Esophageal cancer-associated protein) | UniProt NCBI |
| COMMD3 | COMM domain-containing protein 3 (Protein Bup) (Protein PIL) | UniProt NCBI |
| CCDC22 | Coiled-coil domain-containing protein 22 | UniProt NCBI |
| COMMD2 | COMM domain-containing protein 2 | UniProt NCBI |
| COMMD8 | COMM domain-containing protein 8 | UniProt NCBI |
| COMMD6 | COMM domain-containing protein 6 | UniProt NCBI |
| COMMD7 | COMM domain-containing protein 7 | UniProt NCBI |
| DENND10 | Protein FAM45A | UniProt NCBI |
| COMMD5 | COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) | UniProt NCBI |
| COMMD9 | COMM domain-containing protein 9 | UniProt NCBI |
| COMMD4 | COMM domain-containing protein 4 | UniProt NCBI |
| CCDC93 | Coiled-coil domain-containing protein 93 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6645 | 1.833351519e-41 | 0.866666666667 | COMMD9 CCDC93 COMMD4 COMMD7 COMMD2 CCDC22 COMMD3 COMMD6 VPS35L COMMD1 COMMD5 COMMD8 COMMD10 | CCC complex |
| CORUM:6639 | 1.92453862679e-39 | 0.866666666667 | COMMD9 CCDC93 COMMD4 COMMD7 COMMD2 CCDC22 COMMD3 COMMD6 VPS35L COMMD1 COMMD5 COMMD8 COMMD10 | CCC-Wash (WASH1, FAM21C) complex |
| REAC:R-HSA-8951664 | 2.19227852727e-15 | 0.733333333333 | COMMD9 COMMD4 COMMD5 COMMD10 CCDC22 COMMD3 COMMD7 COMMD1 COMMD8 COMMD2 COMMD6 | Neddylation |
| CORUM:7131 | 3.29702388569e-11 | 0.266666666667 | COMMD1 CCDC93 CCDC22 VPS35L | COMMD1-CCDC22-CCDC93-C16orf62 complex |
| CORUM:7133 | 4.09133189015e-08 | 0.2 | COMMD1 COMMD6 CCDC93 | CCDC93-COMMD1-COMMD6 complex |
| CORUM:7132 | 4.09133189015e-08 | 0.2 | VPS35L CCDC22 CCDC93 | CCDC22-CCDC93-C16orf62 complex |
| CORUM:7134 | 4.09133189015e-08 | 0.2 | COMMD1 CCDC93 VPS35L | COMMD1-CCDC93-C16orf62 complex |
| REAC:R-HSA-597592 | 4.03180187182e-07 | 0.733333333333 | COMMD9 COMMD4 COMMD5 COMMD10 CCDC22 COMMD3 COMMD7 COMMD1 COMMD8 COMMD2 COMMD6 | Post-translational protein modification |
| CORUM:7135 | 4.08638781573e-07 | 0.2 | VPS35L CCDC22 CCDC93 | CCDC22-CCDC93-C16orf62-FAM21-WASH1 complex |
| CORUM:0000000 | 1.56863806762e-05 | 0.866666666667 | COMMD9 CCDC93 COMMD4 COMMD7 COMMD2 CCDC22 COMMD3 COMMD6 VPS35L COMMD1 COMMD5 COMMD8 COMMD10 | CORUM root |
| REAC:R-HSA-392499 | 1.8968860732e-05 | 0.733333333333 | COMMD9 COMMD4 COMMD5 COMMD10 CCDC22 COMMD3 COMMD7 COMMD1 COMMD8 COMMD2 COMMD6 | Metabolism of proteins |
| CORUM:6644 | 0.000140521514535 | 0.133333333333 | COMMD1 CCDC22 | CCDC22-COMMD1-CUL2 complex |
| CORUM:6658 | 0.000140521514535 | 0.133333333333 | COMMD8 CCDC22 | CCDC22-COMMD8-CUL1 complex |
| CORUM:6659 | 0.000140521514535 | 0.133333333333 | COMMD8 CCDC22 | Ubiquitin E3 ligase (CCDC22, COMMD8, CUL3) |
| GO:0098876 | 0.000408246599832 | 0.333333333333 | VPS26C CCDC93 VPS35L CCDC22 COMMD1 | vesicle-mediated transport to the plasma membrane |
| GO:1990126 | 0.00041604535388 | 0.266666666667 | VPS26C CCDC93 CCDC22 VPS35L | retrograde transport, endosome to plasma membrane |
| GO:0032456 | 0.00297916318359 | 0.266666666667 | VPS26C CCDC93 CCDC22 VPS35L | endocytic recycling |
| GO:0006893 | 0.00746309312696 | 0.266666666667 | COMMD1 CCDC93 CCDC22 VPS35L | Golgi to plasma membrane transport |
| GO:0032088 | 0.0168014238015 | 0.266666666667 | COMMD1 COMMD6 CCDC22 COMMD7 | negative regulation of NF-kappaB transcription factor activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COMMD3 | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD3) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD3 | CCDC93 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3) bioplex_WMM youn_WMM hein (CCDC93) gupta_WMM fraction |
| CCDC22 | COMMD2 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD2) bioplex_WMM Guru youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD2 | CCDC93 | 1.0 | 0.949 | hein_WMM bioplex (COMMD2) bioplex_WMM Guru youn_WMM hein (CCDC93) gupta_WMM fraction |
| CCDC22 | CCDC93 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22) bioplex_WMM Guru youn_WMM hein (CCDC22,CCDC93) gupta_WMM fraction |
| COMMD4 | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22,COMMD4) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| DENND10 | COMMD3 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3,DENND10) bioplex_WMM |
| VPS35L | CCDC22 | 1.0 | 0.949 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| VPS35L | COMMD3 | 1.0 | 0.949 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD5 | COMMD3 | 0.999 | 0.949 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD10 | CCDC22 | 0.999 | 0.949 | hein_WMM bioplex (CCDC22,COMMD10) bioplex_WMM Guru hein (CCDC22) fraction |
| COMMD4 | COMMD3 | 0.999 | 0.948 | hein_WMM bioplex (COMMD3,COMMD4) bioplex_WMM youn_WMM gupta_WMM |
| COMMD10 | CCDC93 | 0.998 | 0.939 | hein_WMM bioplex (COMMD10) bioplex_WMM Guru hein (CCDC93) fraction |
| COMMD3 | COMMD2 | 0.997 | 0.932 | hein_WMM bioplex (COMMD2,COMMD3) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD6 | CCDC93 | 0.995 | 0.924 | hein_WMM bioplex (COMMD6) bioplex_WMM hein (CCDC93) gupta_WMM fraction |
| COMMD6 | CCDC22 | 0.993 | 0.918 | hein_WMM bioplex (CCDC22,COMMD6) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD7 | CCDC22 | 0.988 | 0.902 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| COMMD1 | COMMD3 | 0.987 | 0.901 | hein_WMM bioplex (COMMD1,COMMD3) bioplex_WMM youn_WMM gupta_WMM |
| COMMD4 | COMMD7 | 0.987 | 0.901 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD10 | COMMD4 | 0.987 | 0.901 | hein_WMM bioplex (COMMD10,COMMD4) bioplex_WMM fraction |
| COMMD4 | COMMD2 | 0.986 | 0.9 | hein_WMM bioplex (COMMD2,COMMD4) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD4 | COMMD9 | 0.983 | 0.899 | hein_WMM bioplex (COMMD4) bioplex_WMM |
| DENND10 | COMMD4 | 0.982 | 0.898 | hein_WMM bioplex (COMMD4,DENND10) bioplex_WMM fraction |
| COMMD5 | CCDC22 | 0.978 | 0.894 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| VPS26C | CCDC93 | 0.968 | 0.88 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| COMMD10 | COMMD3 | 0.939 | 0.851 | hein_WMM bioplex (COMMD10,COMMD3) bioplex_WMM fraction |
| DENND10 | CCDC93 | 0.921 | 0.844 | hein_WMM bioplex (DENND10) bioplex_WMM hein (CCDC93) fraction |
| COMMD8 | CCDC22 | 0.911 | 0.834 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| COMMD9 | COMMD3 | 0.903 | 0.827 | hein_WMM bioplex (COMMD3) bioplex_WMM fraction |
| COMMD9 | CCDC22 | 0.901 | 0.826 | hein_WMM bioplex (CCDC22) bioplex_WMM hein (CCDC22) fraction |
| VPS26C | COMMD3 | 0.889 | 0.818 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD6 | VPS35L | 0.86 | 0.796 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| COMMD8 | COMMD3 | 0.855 | 0.793 | hein_WMM bioplex (COMMD3,COMMD8) bioplex_WMM youn_WMM gupta_WMM |
| COMMD6 | COMMD4 | 0.847 | 0.79 | hein_WMM bioplex (COMMD4,COMMD6) bioplex_WMM gupta_WMM |
| COMMD7 | COMMD3 | 0.817 | 0.773 | hein_WMM bioplex (COMMD3) bioplex_WMM |
| COMMD6 | COMMD1 | 0.807 | 0.767 | hein_WMM bioplex (COMMD1,COMMD6) bioplex_WMM gupta_WMM |
| VPS26C | CCDC22 | 0.75 | 0.743 | hein_WMM bioplex_WMM hein (CCDC22) fraction |
| COMMD6 | COMMD5 | 0.722 | 0.732 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| VPS35L | COMMD4 | 0.713 | 0.728 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD7 | COMMD2 | 0.673 | 0.706 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| COMMD4 | COMMD5 | 0.645 | 0.687 | hein_WMM bioplex (COMMD4) bioplex_WMM fraction |
| COMMD8 | VPS35L | 0.641 | 0.688 | hein_WMM bioplex (COMMD8) bioplex_WMM fraction |
| COMMD10 | COMMD7 | 0.631 | 0.681 | hein_WMM bioplex (COMMD10) bioplex_WMM |
| COMMD7 | CCDC93 | 0.623 | 0.678 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| COMMD8 | COMMD9 | 0.62 | 0.676 | hein_WMM bioplex (COMMD8) bioplex_WMM |
| COMMD10 | COMMD9 | 0.608 | 0.674 | hein_WMM bioplex (COMMD10) bioplex_WMM |
| COMMD8 | COMMD10 | 0.605 | 0.672 | hein_WMM bioplex (COMMD10,COMMD8) bioplex_WMM |
| COMMD1 | COMMD9 | 0.577 | 0.659 | hein_WMM bioplex (COMMD1) bioplex_WMM |
| DENND10 | CCDC22 | 0.515 | 0.632 | hein_WMM bioplex (CCDC22,DENND10) bioplex_WMM hein (CCDC22) fraction |
| VPS35L | COMMD2 | 0.508 | 0.628 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| DENND10 | COMMD7 | 0.479 | 0.612 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD10 | COMMD6 | 0.476 | 0.609 | hein_WMM bioplex (COMMD10,COMMD6) bioplex_WMM |
| COMMD8 | COMMD5 | 0.453 | 0.595 | hein_WMM bioplex (COMMD8) bioplex_WMM fraction |
| DENND10 | COMMD9 | 0.443 | 0.586 | hein_WMM bioplex (DENND10) bioplex_WMM |
| COMMD6 | COMMD2 | 0.415 | 0.572 | hein_WMM bioplex (COMMD2,COMMD6) bioplex_WMM youn_WMM gupta_WMM |
| COMMD9 | COMMD2 | 0.415 | 0.571 | hein_WMM bioplex (COMMD2) bioplex_WMM |
| COMMD6 | COMMD3 | 0.402 | 0.561 | hein_WMM bioplex (COMMD3,COMMD6) bioplex_WMM gupta_WMM fraction |
| COMMD5 | COMMD2 | 0.383 | 0.551 | hein_WMM bioplex (COMMD2) bioplex_WMM fraction |
| COMMD8 | COMMD4 | 0.381 | 0.549 | hein_WMM bioplex (COMMD4,COMMD8) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD8 | COMMD6 | 0.379 | 0.548 | hein_WMM bioplex (COMMD6,COMMD8) bioplex_WMM youn_WMM gupta_WMM |
| COMMD8 | VPS26C | 0.349 | 0.536 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD10 | COMMD2 | 0.348 | 0.536 | hein_WMM bioplex (COMMD10,COMMD2) bioplex_WMM Guru fraction |
| COMMD6 | VPS26C | 0.327 | 0.516 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| COMMD9 | CCDC93 | 0.322 | 0.512 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| COMMD1 | COMMD7 | 0.317 | 0.51 | hein_WMM bioplex (COMMD1) bioplex_WMM fraction |
| DENND10 | COMMD6 | 0.31 | 0.503 | hein_WMM bioplex (COMMD6,DENND10) bioplex_WMM |
| COMMD6 | COMMD9 | 0.307 | 0.502 | hein_WMM bioplex (COMMD6) bioplex_WMM fraction |
| COMMD8 | COMMD7 | 0.293 | 0.493 | hein_WMM bioplex (COMMD8) bioplex_WMM fraction |
| COMMD6 | COMMD7 | 0.291 | 0.492 | hein_WMM bioplex (COMMD6) bioplex_WMM |
| COMMD1 | CCDC93 | 0.263 | 0.481 | hein_WMM bioplex (COMMD1) bioplex_WMM youn_WMM hein (CCDC93) fraction |
| COMMD8 | COMMD2 | 0.235 | 0.469 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD10 | VPS35L | 0.153 | 0.411 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| DENND10 | COMMD10 | 0.125 | 0.399 | hein_WMM bioplex (COMMD10,DENND10) bioplex_WMM fraction |
| DENND10 | VPS26C | 0.113 | 0.38 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD7 | COMMD5 | 0.101 | 0.364 | hein_WMM bioplex_WMM fraction |
| DENND10 | COMMD8 | 0.096 | 0.358 | hein_WMM bioplex (COMMD8,DENND10) bioplex_WMM fraction |
| DENND10 | COMMD1 | 0.083 | 0.349 | hein_WMM bioplex (COMMD1,DENND10) bioplex_WMM fraction |
| DENND10 | COMMD2 | 0.079 | 0.352 | hein_WMM bioplex (COMMD2,DENND10) bioplex_WMM fraction |
| VPS35L | CCDC93 | 0.079 | 0.353 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| VPS35L | COMMD7 | 0.072 | 0.353 | hein_WMM bioplex_WMM fraction |
| COMMD8 | CCDC93 | 0.059 | 0.328 | hein_WMM bioplex (COMMD8) bioplex_WMM youn_WMM hein (CCDC93) gupta_WMM fraction |
| COMMD5 | COMMD9 | 0.059 | 0.328 | hein_WMM bioplex_WMM WMM_only |
| COMMD10 | COMMD5 | 0.058 | 0.325 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| VPS35L | COMMD9 | 0.057 | 0.324 | hein_WMM bioplex_WMM WMM_only |
| DENND10 | VPS35L | 0.054 | 0.303 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD7 | COMMD9 | 0.047 | 0.293 | hein_WMM bioplex_WMM WMM_only |
| COMMD4 | CCDC93 | 0.043 | 0.268 | hein_WMM bioplex (COMMD4) bioplex_WMM youn_WMM gupta_WMM fraction |
| DENND10 | COMMD5 | 0.039 | 0.266 | hein_WMM bioplex (DENND10) bioplex_WMM fraction |
| COMMD5 | CCDC93 | 0.038 | 0.264 | hein_WMM bioplex_WMM hein (CCDC93) fraction |
| VPS26C | COMMD9 | 0.034 | 0.261 | hein_WMM bioplex_WMM WMM_only |
| COMMD1 | VPS35L | 0.032 | 0.241 | hein_WMM bioplex (COMMD1) bioplex_WMM fraction |
| COMMD10 | COMMD1 | 0.03 | 0.233 | hein_WMM bioplex (COMMD1,COMMD10) bioplex_WMM fraction |
| VPS26C | COMMD1 | 0.025 | 0.215 | hein_WMM bioplex (COMMD1) bioplex_WMM fraction |
| COMMD8 | COMMD1 | 0.025 | 0.211 | hein_WMM bioplex (COMMD1,COMMD8) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD1 | COMMD2 | 0.014 | 0.138 | hein_WMM bioplex (COMMD1) bioplex_WMM youn_WMM gupta_WMM fraction |
| COMMD1 | CCDC22 | 0.012 | 0.15 | hein_WMM bioplex (CCDC22,COMMD1) bioplex_WMM youn_WMM hein (CCDC22) gupta_WMM fraction |
| VPS26C | COMMD7 | 0.011 | 0.141 | hein_WMM bioplex_WMM fraction |
| VPS35L | COMMD5 | 0.005 | 0.014 | hein_WMM bioplex_WMM fraction |
| COMMD1 | COMMD5 | 0.005 | 0.007 | hein_WMM bioplex (COMMD1) bioplex_WMM fraction |
| COMMD10 | VPS26C | 0.004 | 0.007 | hein_WMM bioplex (COMMD10) bioplex_WMM fraction |
| VPS26C | COMMD2 | 0.003 | 0.014 | hein_WMM bioplex_WMM youn_WMM fraction |
| COMMD1 | COMMD4 | 0.0 | 0.008 | hein_WMM bioplex (COMMD1,COMMD4) bioplex_WMM youn_WMM gupta_WMM fraction |
| VPS26C | COMMD4 | 0.0 | 0.015 | hein_WMM bioplex (COMMD4) bioplex_WMM gupta_WMM fraction |
| VPS26C | VPS35L | 0.0 | 0.001 | hein_WMM bioplex_WMM fraction |
| VPS26C | COMMD5 | 0.0 | 0.0 | hein_WMM bioplex_WMM fraction |
Images
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Complex HuMAP2_06442 has an average edge precision of 0.578 which is ranked 2047 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VPS26C | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 HuMAP2_06842 |
| COMMD10 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD1 | HuMAP2_00773 HuMAP2_06442 |
| VPS35L | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD3 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_05140 HuMAP2_06442 |
| CCDC22 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_05140 HuMAP2_06442 |
| COMMD2 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD8 | HuMAP2_00773 HuMAP2_03509 HuMAP2_06442 HuMAP2_06842 |
| COMMD6 | HuMAP2_00773 HuMAP2_00912 HuMAP2_06442 |
| COMMD7 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| DENND10 | HuMAP2_00458 HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD5 | HuMAP2_00773 HuMAP2_00912 HuMAP2_06442 |
| COMMD9 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| COMMD4 | HuMAP2_00773 HuMAP2_00912 HuMAP2_03509 HuMAP2_06442 |
| CCDC93 | HuMAP2_00773 HuMAP2_03509 HuMAP2_05140 HuMAP2_06442 |