hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06446

Confidence: Medium

Genename	Protein Name	Links
IMMT	MICOS complex subunit MIC60 (Cell proliferation-inducing gene 4/52 protein) (Mitochondrial inner membrane protein) (Mitofilin) (p87/89)	UniProt NCBI
SAMM50	Sorting and assembly machinery component 50 homolog (Transformation-related gene 3 protein) (TRG-3)	UniProt NCBI
CHCHD6	MICOS complex subunit MIC25 (Coiled-coil-helix cristae morphology protein 1) (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6)	UniProt NCBI
CHCHD3	MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3)	UniProt NCBI
TIMMDC1	Complex I assembly factor TIMMDC1, mitochondrial (Protein M5-14) (Translocase of inner mitochondrial membrane domain-containing protein 1) (TIMM domain containing-protein 1)	UniProt NCBI
SLC25A12	Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12)	UniProt NCBI
TMEM263	Transmembrane protein 263	UniProt NCBI
TMEM126B	Complex I assembly factor TMEM126B, mitochondrial (Transmembrane protein 126B)	UniProt NCBI
MTX3	Metaxin-3	UniProt NCBI
MTX2	Metaxin-2 (Mitochondrial outer membrane import complex protein 2)	UniProt NCBI
CCDC127	Coiled-coil domain-containing protein 127	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6249	1.28841207851e-12	0.454545454545	IMMT SAMM50 CHCHD6 CHCHD3 MTX2	MIB complex
REAC:R-HSA-8949613	2.34572764521e-09	0.454545454545	IMMT SAMM50 CHCHD6 CHCHD3 MTX2	Cristae formation
CORUM:6255	4.05059760518e-07	0.272727272727	IMMT CHCHD6 CHCHD3	MICOS complex
REAC:R-HSA-1592230	6.32382207417e-07	0.454545454545	IMMT SAMM50 CHCHD6 CHCHD3 MTX2	Mitochondrial biogenesis
GO:0031966	9.65378305945e-06	0.727272727273	IMMT CHCHD6 MTX2 SLC25A12 TMEM126B TIMMDC1 SAMM50 CHCHD3	mitochondrial membrane
GO:0005740	1.62380721178e-05	0.727272727273	IMMT CHCHD6 MTX2 SLC25A12 TMEM126B TIMMDC1 SAMM50 CHCHD3	mitochondrial envelope
REAC:R-HSA-1268020	1.685878186e-05	0.363636363636	MTX2 SLC25A12 CHCHD3 SAMM50	Mitochondrial protein import
CORUM:6132	0.000100616904936	0.181818181818	IMMT CHCHD3	MINOS complex
REAC:R-HSA-1852241	0.000205613305796	0.454545454545	IMMT SAMM50 CHCHD6 CHCHD3 MTX2	Organelle biogenesis and maintenance
GO:0042407	0.000218476600449	0.363636363636	IMMT CHCHD6 CHCHD3 SAMM50	cristae formation
GO:0044429	0.000441718637942	0.727272727273	IMMT CHCHD6 MTX2 SLC25A12 TMEM126B TIMMDC1 SAMM50 CHCHD3	mitochondrial part
GO:0061617	0.000523632447094	0.272727272727	IMMT CHCHD6 CHCHD3	MICOS complex
GO:0031975	0.000592154236364	0.727272727273	IMMT CHCHD6 MTX2 SLC25A12 TMEM126B TIMMDC1 SAMM50 CHCHD3	envelope
GO:0031967	0.000592154236364	0.727272727273	IMMT CHCHD6 MTX2 SLC25A12 TMEM126B TIMMDC1 SAMM50 CHCHD3	organelle envelope
REAC:R-HSA-9609507	0.000607902960483	0.363636363636	MTX2 SLC25A12 CHCHD3 SAMM50	Protein localization
GO:0007007	0.000888298147616	0.363636363636	IMMT CHCHD6 CHCHD3 SAMM50	inner mitochondrial membrane organization
GO:0005743	0.00392424957483	0.545454545455	IMMT CHCHD6 TIMMDC1 SLC25A12 TMEM126B CHCHD3	mitochondrial inner membrane
GO:0019866	0.00622089080158	0.545454545455	IMMT CHCHD6 TIMMDC1 SLC25A12 TMEM126B CHCHD3	organelle inner membrane
HP:0000817	0.00854182692524	0.272727272727	TMEM126B SLC25A12 TIMMDC1	Poor eye contact
GO:0005739	0.00968731959025	0.727272727273	IMMT CHCHD6 MTX2 SLC25A12 TMEM126B TIMMDC1 SAMM50 CHCHD3	mitochondrion
GO:0007005	0.0108137793798	0.545454545455	IMMT CHCHD6 TIMMDC1 TMEM126B SAMM50 CHCHD3	mitochondrion organization
HP:0000735	0.0196046305361	0.272727272727	TMEM126B SLC25A12 TIMMDC1	Impaired social interactions
GO:0007006	0.0430491034351	0.363636363636	IMMT CHCHD6 CHCHD3 SAMM50	mitochondrial membrane organization
WP:WP4324	0.0452947970315	0.181818181818	TMEM126B TIMMDC1	Mitochondrial complex I assembly model OXPHOS system

Edges

Protein 1	Protein 2	Score	Precision	Evidence
MTX2	IMMT	1.0	0.949	hein_WMM bioplex (MTX2) bioplex_WMM Guru boldt hein (MTX2) fraction boldt_WMM
MTX2	SAMM50	1.0	0.949	hein_WMM bioplex (MTX2) bioplex_WMM boldt youn_WMM hein (MTX2) boldt_WMM
MTX2	CHCHD6	1.0	0.949	hein_WMM bioplex (MTX2) bioplex_WMM boldt hein (MTX2) boldt_WMM
MTX2	CHCHD3	0.997	0.93	hein_WMM bioplex (MTX2) bioplex_WMM boldt hein (MTX2) boldt_WMM
MTX2	MTX3	0.996	0.926	hein_WMM bioplex (MTX2) bioplex_WMM hein (MTX2)
SAMM50	CHCHD3	0.73	0.735	hein_WMM bioplex_WMM boldt hein (SAMM50) boldt_WMM
IMMT	CHCHD3	0.064	0.349	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
IMMT	CHCHD6	0.04	0.269	hein_WMM bioplex_WMM boldt boldt_WMM
SAMM50	CHCHD6	0.031	0.238	hein_WMM bioplex_WMM boldt boldt_WMM
TIMMDC1	IMMT	0.029	0.233	bioplex (TIMMDC1) bioplex_WMM boldt fraction boldt_WMM
MTX2	CCDC127	0.025	0.213	hein_WMM hein (MTX2)
IMMT	SLC25A12	0.022	0.209	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
IMMT	SAMM50	0.022	0.199	hein_WMM bioplex_WMM boldt boldt_WMM
TMEM263	TIMMDC1	0.022	0.196	bioplex (TIMMDC1) bioplex_WMM boldt boldt_WMM
TMEM126B	TIMMDC1	0.021	0.195	bioplex (TIMMDC1,TMEM126B) bioplex_WMM
CHCHD6	CHCHD3	0.021	0.192	hein_WMM bioplex_WMM boldt boldt_WMM
MTX3	SAMM50	0.01	0.103	hein_WMM bioplex_WMM WMM_only
MTX3	IMMT	0.009	0.111	hein_WMM bioplex_WMM WMM_only
MTX3	CHCHD6	0.009	0.095	hein_WMM bioplex_WMM WMM_only
MTX3	CHCHD3	0.008	0.06	hein_WMM bioplex_WMM WMM_only
MTX3	CCDC127	0.008	0.012	hein_WMM WMM_only
CCDC127	SAMM50	0.007	0.01	hein_WMM WMM_only
CCDC127	CHCHD6	0.007	0.007	hein_WMM WMM_only
IMMT	CCDC127	0.007	0.005	hein_WMM WMM_only
TMEM263	CCDC127	0.007	0.005	hein_WMM WMM_only
CCDC127	CHCHD3	0.006	0.003	hein_WMM WMM_only
TMEM126B	MTX3	0.006	0.001	bioplex_WMM WMM_only
MTX3	SLC25A12	0.006	0.004	bioplex_WMM WMM_only
TMEM126B	SLC25A12	0.006	0.008	bioplex_WMM WMM_only
TIMMDC1	MTX3	0.006	0.008	bioplex_WMM WMM_only
TMEM263	MTX3	0.006	0.01	hein_WMM bioplex_WMM WMM_only
TIMMDC1	SLC25A12	0.005	0.005	bioplex (TIMMDC1) bioplex_WMM boldt boldt_WMM
TMEM126B	CHCHD6	0.005	0.007	bioplex_WMM WMM_only
TMEM126B	MTX2	0.005	0.006	bioplex_WMM WMM_only
TMEM126B	SAMM50	0.005	0.012	bioplex_WMM WMM_only
CHCHD3	SLC25A12	0.004	0.013	bioplex_WMM boldt youn_WMM boldt_WMM
TIMMDC1	CHCHD6	0.004	0.014	bioplex (TIMMDC1) bioplex_WMM boldt boldt_WMM
TMEM126B	IMMT	0.004	0.015	bioplex (TMEM126B) bioplex_WMM
TIMMDC1	SAMM50	0.004	0.014	bioplex (TIMMDC1) bioplex_WMM boldt boldt_WMM
TIMMDC1	CHCHD3	0.004	0.01	bioplex (TIMMDC1) bioplex_WMM boldt boldt_WMM
TMEM263	TMEM126B	0.004	0.009	bioplex_WMM WMM_only
TMEM126B	CHCHD3	0.004	0.009	bioplex (TMEM126B) bioplex_WMM
TMEM263	CHCHD3	0.004	0.007	hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM
CHCHD6	SLC25A12	0.004	0.007	bioplex_WMM WMM_only boldt_WMM
TMEM263	SLC25A12	0.004	0.016	bioplex_WMM boldt youn_WMM boldt_WMM
TMEM263	IMMT	0.004	0.017	hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM
MTX2	SLC25A12	0.003	0.016	bioplex_WMM WMM_only
SAMM50	SLC25A12	0.003	0.014	bioplex_WMM boldt boldt_WMM
TMEM263	MTX2	0.003	0.008	hein_WMM bioplex_WMM hein (MTX2)
TIMMDC1	MTX2	0.003	0.011	bioplex (TIMMDC1) bioplex_WMM
TMEM263	CHCHD6	0.003	0.014	hein_WMM bioplex_WMM WMM_only
TMEM263	SAMM50	0.003	0.011	hein_WMM bioplex_WMM WMM_only boldt_WMM

Images

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Complex HuMAP2_06446 has an average edge precision of 0.162 which is ranked 6611 out of all 6965 complexes.

Related Complexes

Genename	Complexes
IMMT	HuMAP2_01309 HuMAP2_03066 HuMAP2_04962 HuMAP2_06446
SAMM50	HuMAP2_01309 HuMAP2_03066 HuMAP2_04962 HuMAP2_06446
CHCHD6	HuMAP2_01309 HuMAP2_03066 HuMAP2_04962 HuMAP2_06446
CHCHD3	HuMAP2_01309 HuMAP2_03066 HuMAP2_04590 HuMAP2_04962 HuMAP2_06446
TIMMDC1	HuMAP2_00306 HuMAP2_01439 HuMAP2_06446
SLC25A12	HuMAP2_06446 HuMAP2_06631
TMEM263	HuMAP2_00306 HuMAP2_01439 HuMAP2_06446
TMEM126B	HuMAP2_00306 HuMAP2_01439 HuMAP2_04892 HuMAP2_06446
MTX3	HuMAP2_01309 HuMAP2_02736 HuMAP2_03066 HuMAP2_04962 HuMAP2_06446
MTX2	HuMAP2_00654 HuMAP2_01309 HuMAP2_02736 HuMAP2_03066 HuMAP2_04962 HuMAP2_06446
CCDC127	HuMAP2_01309 HuMAP2_02736 HuMAP2_06446

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06446