hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06447
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RABL6 | Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) | UniProt NCBI |
| AP3S1 | AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) | UniProt NCBI |
| AP3D1 | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) | UniProt NCBI |
| RNF167 | E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) (RING-type E3 ubiquitin transferase RNF167) (RING105) | UniProt NCBI |
| RNF13 | E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) (RING-type E3 ubiquitin transferase RNF13) | UniProt NCBI |
| AP3B1 | AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain) | UniProt NCBI |
| TYK2 | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | UniProt NCBI |
| AP3M1 | AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) | UniProt NCBI |
| AP3S2 | AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b) | UniProt NCBI |
| AP3M2 | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | UniProt NCBI |
| AP3B2 | AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:59 | 6.93111371734e-22 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | AP3 adaptor complex |
| CORUM:652 | 4.45178808574e-18 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | AP3-BLOC1 complex |
| GO:0048490 | 9.93804560737e-15 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | anterograde synaptic vesicle transport |
| GO:0099517 | 9.93804560737e-15 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | synaptic vesicle transport along microtubule |
| GO:0099514 | 9.93804560737e-15 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | synaptic vesicle cytoskeletal transport |
| GO:0048489 | 2.73803870741e-12 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | synaptic vesicle transport |
| GO:0047496 | 6.41722626669e-12 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | vesicle transport along microtubule |
| GO:0008089 | 6.41722626669e-12 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | anterograde axonal transport |
| GO:0097479 | 9.47552842435e-12 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | synaptic vesicle localization |
| GO:0099518 | 2.30368908036e-11 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | vesicle cytoskeletal trafficking |
| KEGG:04142 | 2.37000350615e-11 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | Lysosome |
| GO:0098930 | 2.71653155512e-11 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | axonal transport |
| GO:0008088 | 5.86899962959e-11 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | axo-dendritic transport |
| GO:0072384 | 3.13949968137e-10 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | organelle transport along microtubule |
| GO:0010970 | 4.97424400721e-08 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | transport along microtubule |
| GO:0099111 | 1.08943507371e-07 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | microtubule-based transport |
| GO:0030705 | 1.60022115294e-07 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | cytoskeleton-dependent intracellular transport |
| GO:0051650 | 2.10669185282e-07 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | establishment of vesicle localization |
| GO:0051648 | 2.99083560486e-07 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | vesicle localization |
| GO:0007018 | 3.18147067639e-06 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | microtubule-based movement |
| GO:0051656 | 2.59996914319e-05 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | establishment of organelle localization |
| CORUM:2308 | 3.35524866385e-05 | 0.181818181818 | AP3S1 AP3D1 | AP3D1-AP3S1 complex |
| CORUM:2307 | 3.35524866385e-05 | 0.181818181818 | AP3S2 AP3D1 | AP3D1-AP3S2 complex |
| GO:0030123 | 0.000149729915117 | 0.272727272727 | AP3S2 AP3S1 AP3D1 | AP-3 adaptor complex |
| GO:0030119 | 0.000189417697176 | 0.363636363636 | AP3S2 AP3S1 AP3M2 AP3D1 | AP-type membrane coat adaptor complex |
| GO:0051640 | 0.000580164107342 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | organelle localization |
| GO:0007017 | 0.00319219813068 | 0.636363636364 | AP3S2 AP3S1 AP3M2 AP3D1 AP3B1 AP3B2 AP3M1 | microtubule-based process |
| GO:0048475 | 0.00853763565651 | 0.363636363636 | AP3S2 AP3S1 AP3M2 AP3D1 | coated membrane |
| GO:0030117 | 0.00853763565651 | 0.363636363636 | AP3S2 AP3S1 AP3M2 AP3D1 | membrane coat |
| CORUM:0000000 | 0.0434839362249 | 0.727272727273 | AP3S2 AP3S1 AP3B1 AP3M2 AP3D1 TYK2 AP3B2 AP3M1 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AP3D1 | AP3B1 | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP3S1 | AP3D1 | 0.994 | 0.919 | bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3S1 | AP3B1 | 0.988 | 0.901 | bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3D1 | AP3M1 | 0.988 | 0.901 | bioplex (AP3M1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3S1 | AP3M1 | 0.988 | 0.901 | bioplex (AP3M1,AP3S1) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP3M1 | AP3B1 | 0.988 | 0.901 | bioplex (AP3M1) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| AP3S1 | AP3B2 | 0.967 | 0.877 | bioplex (AP3S1) bioplex_WMM youn_WMM |
| AP3M1 | AP3B2 | 0.922 | 0.843 | bioplex (AP3M1) bioplex_WMM youn_WMM |
| AP3S1 | AP3M2 | 0.792 | 0.758 | bioplex (AP3M2,AP3S1) bioplex_WMM youn_WMM fraction |
| AP3S1 | RABL6 | 0.448 | 0.592 | hein_WMM bioplex (AP3S1) bioplex_WMM youn_WMM gupta_WMM |
| AP3M1 | AP3S2 | 0.427 | 0.576 | bioplex (AP3M1) bioplex_WMM youn_WMM |
| AP3S1 | RNF13 | 0.281 | 0.487 | bioplex (RNF13) bioplex_WMM |
| AP3B1 | AP3M2 | 0.253 | 0.477 | bioplex (AP3M2) bioplex_WMM youn_WMM fraction |
| RNF13 | AP3S2 | 0.187 | 0.44 | bioplex (RNF13) bioplex_WMM |
| AP3M1 | AP3M2 | 0.1 | 0.361 | bioplex (AP3M1) bioplex_WMM youn_WMM |
| AP3D1 | AP3M2 | 0.098 | 0.357 | bioplex (AP3M2) bioplex_WMM youn_WMM fraction |
| AP3M1 | RABL6 | 0.083 | 0.351 | bioplex (AP3M1) bioplex_WMM youn_WMM gupta_WMM |
| AP3S1 | RNF167 | 0.04 | 0.268 | bioplex (AP3S1) bioplex_WMM |
| AP3D1 | RNF13 | 0.03 | 0.239 | bioplex (RNF13) bioplex_WMM |
| RNF13 | TYK2 | 0.027 | 0.228 | bioplex (RNF13) bioplex_WMM |
| AP3D1 | AP3S2 | 0.021 | 0.194 | bioplex_WMM youn_WMM WMM_only |
| AP3S1 | AP3S2 | 0.015 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| AP3B1 | AP3S2 | 0.013 | 0.143 | bioplex_WMM youn_WMM WMM_only |
| AP3M2 | AP3B2 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| AP3B1 | AP3B2 | 0.011 | 0.141 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP3M2 | AP3S2 | 0.01 | 0.099 | bioplex (AP3M2) bioplex_WMM |
| RABL6 | AP3B2 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| AP3D1 | AP3B2 | 0.009 | 0.103 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP3D1 | RABL6 | 0.009 | 0.105 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RABL6 | AP3M2 | 0.009 | 0.097 | bioplex_WMM youn_WMM WMM_only |
| RABL6 | AP3B1 | 0.008 | 0.087 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP3B2 | AP3S2 | 0.008 | 0.069 | bioplex_WMM WMM_only |
| AP3D1 | RNF167 | 0.008 | 0.055 | bioplex_WMM WMM_only |
| RABL6 | AP3S2 | 0.008 | 0.009 | bioplex_WMM youn_WMM WMM_only |
| RNF167 | AP3B2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| RABL6 | RNF167 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RNF167 | AP3M2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| RNF167 | AP3S2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| AP3S2 | TYK2 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| RNF167 | AP3B1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| RABL6 | TYK2 | 0.007 | 0.002 | gupta_WMM WMM_only |
| AP3B1 | TYK2 | 0.007 | 0.002 | gupta_WMM WMM_only treiber_WMM |
| AP3M1 | RNF167 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| AP3D1 | TYK2 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
| RNF167 | RNF13 | 0.007 | 0.001 | bioplex (RNF13) bioplex_WMM |
| AP3B1 | RNF13 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| AP3M1 | RNF13 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RNF167 | TYK2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| AP3M1 | TYK2 | 0.007 | 0.007 | bioplex_WMM gupta_WMM WMM_only |
| AP3S1 | TYK2 | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06447 has an average edge precision of 0.278 which is ranked 4907 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RABL6 | HuMAP2_00924 HuMAP2_02783 HuMAP2_06447 |
| AP3S1 | HuMAP2_00924 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |
| AP3D1 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| RNF167 | HuMAP2_00924 HuMAP2_02783 HuMAP2_06447 |
| RNF13 | HuMAP2_02783 HuMAP2_04084 HuMAP2_06447 HuMAP2_06850 |
| AP3B1 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| TYK2 | HuMAP2_05938 HuMAP2_06447 HuMAP2_06850 |
| AP3M1 | HuMAP2_00924 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |
| AP3S2 | HuMAP2_02783 HuMAP2_04084 HuMAP2_06447 HuMAP2_06850 |
| AP3M2 | HuMAP2_00924 HuMAP2_05936 HuMAP2_06447 |
| AP3B2 | HuMAP2_00924 HuMAP2_01887 HuMAP2_02783 HuMAP2_05936 HuMAP2_06447 |