hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06448
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MZT2B | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | UniProt NCBI |
| MZT2A | Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A) | UniProt NCBI |
| TUBGCP6 | Gamma-tubulin complex component 6 (GCP-6) | UniProt NCBI |
| TUBGCP5 | Gamma-tubulin complex component 5 (GCP-5) | UniProt NCBI |
| MZT1 | Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) | UniProt NCBI |
| TUBGCP4 | Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) | UniProt NCBI |
| TUBG1 | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | UniProt NCBI |
| TUBGCP2 | Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) | UniProt NCBI |
| TUBGCP3 | Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) | UniProt NCBI |
| NME7 | Nucleoside diphosphate kinase 7 (NDK 7) (NDP kinase 7) (EC 2.7.4.6) (nm23-H7) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000930 | 8.4644303789e-22 | 0.9 | MZT2B TUBGCP4 MZT1 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | gamma-tubulin complex |
| REAC:R-HSA-380270 | 2.04221651179e-21 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 2.04221651179e-21 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | Centrosome maturation |
| REAC:R-HSA-380320 | 8.10922052454e-21 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | Recruitment of NuMA to mitotic centrosomes |
| CORUM:6893 | 1.03162501538e-18 | 0.6 | TUBGCP2 TUBGCP6 TUBGCP5 TUBGCP4 TUBG1 TUBGCP3 | Gamma-tubulin complex |
| REAC:R-HSA-69275 | 1.88230264515e-17 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | G2/M Transition |
| REAC:R-HSA-68877 | 1.98629726643e-17 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | Mitotic Prometaphase |
| REAC:R-HSA-453274 | 2.09543447888e-17 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | Mitotic G2-G2/M phases |
| GO:0051415 | 6.93252010332e-16 | 0.6 | MZT1 TUBGCP2 TUBGCP5 TUBGCP4 TUBGCP6 TUBGCP3 | microtubule nucleation by interphase microtubule organizing center |
| GO:0000931 | 1.94021166969e-14 | 0.6 | MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP4 MZT2A | gamma-tubulin large complex |
| GO:0051418 | 1.94021166969e-14 | 0.6 | MZT1 TUBGCP2 TUBGCP5 TUBGCP4 TUBGCP6 TUBGCP3 | microtubule nucleation by microtubule organizing center |
| GO:0008274 | 1.94021166969e-14 | 0.6 | MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP4 MZT2A | gamma-tubulin ring complex |
| REAC:R-HSA-68886 | 2.0086519868e-14 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | M Phase |
| GO:0007020 | 8.92503012063e-14 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | microtubule nucleation |
| GO:0044450 | 3.0314351021e-13 | 0.9 | MZT2B TUBGCP4 MZT1 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | microtubule organizing center part |
| REAC:R-HSA-69278 | 4.78805300306e-13 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | Cell Cycle, Mitotic |
| GO:0000923 | 2.06436583637e-12 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | equatorial microtubule organizing center |
| REAC:R-HSA-1640170 | 2.95031995123e-12 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | Cell Cycle |
| GO:0005813 | 3.14323779225e-11 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | centrosome |
| GO:0046785 | 1.60271216282e-10 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | microtubule polymerization |
| GO:0005815 | 5.06203702432e-10 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | microtubule organizing center |
| GO:0051011 | 1.63177713021e-09 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | microtubule minus-end binding |
| GO:0031109 | 2.18538720927e-09 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | microtubule polymerization or depolymerization |
| GO:0043015 | 1.7623227689e-08 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | gamma-tubulin binding |
| GO:0007051 | 3.99373424482e-08 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | spindle organization |
| GO:0015630 | 4.44597734103e-08 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | microtubule cytoskeleton |
| GO:0051225 | 4.23340126472e-07 | 0.6 | MZT1 TUBGCP2 TUBGCP5 TUBGCP4 TUBGCP6 TUBGCP3 | spindle assembly |
| GO:0051258 | 4.41047204125e-07 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | protein polymerization |
| GO:0044430 | 5.07582717362e-07 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | cytoskeletal part |
| GO:0032155 | 1.73798191785e-06 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | cell division site part |
| GO:0031122 | 2.21755613333e-06 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | cytoplasmic microtubule organization |
| GO:0032153 | 3.12956734431e-06 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | cell division site |
| GO:0051321 | 4.20922382185e-06 | 0.6 | TUBGCP2 TUBGCP6 TUBGCP5 TUBGCP4 TUBG1 TUBGCP3 | meiotic cell cycle |
| GO:0005856 | 4.3838587487e-06 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | cytoskeleton |
| CORUM:3714 | 9.0534767973e-05 | 0.2 | TUBGCP2 TUBGCP3 | Pericentrin-GCP complex |
| GO:0000226 | 0.000139746410951 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | microtubule cytoskeleton organization |
| GO:0097435 | 0.000249928184778 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | supramolecular fiber organization |
| GO:0007017 | 0.00120455232504 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | microtubule-based process |
| GO:0070925 | 0.00207003014643 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | organelle assembly |
| GO:0008017 | 0.00495516852329 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | microtubule binding |
| GO:0000278 | 0.0085673537644 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | mitotic cell cycle |
| GO:0005819 | 0.0093184030836 | 0.5 | MZT1 TUBG1 TUBGCP3 MZT2A MZT2B | spindle |
| GO:0034622 | 0.0097650864535 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | cellular protein-containing complex assembly |
| HPA:031020_21 | 0.0200952261868 | 0.7 | MZT2B MZT1 TUBGCP2 MZT2A TUBGCP4 TUBGCP6 TUBGCP3 | ovary; ovarian stroma cells[Approved,Low] |
| GO:0022414 | 0.0202708082252 | 0.6 | TUBGCP2 TUBGCP6 TUBGCP5 TUBGCP4 TUBG1 TUBGCP3 | reproductive process |
| GO:0000003 | 0.0207186323534 | 0.6 | TUBGCP2 TUBGCP6 TUBGCP5 TUBGCP4 TUBG1 TUBGCP3 | reproduction |
| GO:0015631 | 0.0212718480042 | 0.5 | TUBGCP4 TUBGCP6 TUBGCP3 TUBGCP2 TUBGCP5 | tubulin binding |
| GO:0043232 | 0.0298047658367 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | intracellular non-membrane-bounded organelle |
| GO:0043228 | 0.0299730351788 | 1.0 | MZT2B NME7 MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBG1 TUBGCP6 TUBGCP3 MZT2A | non-membrane-bounded organelle |
| GO:0007010 | 0.0372250404573 | 0.7 | MZT1 TUBGCP4 TUBGCP2 TUBGCP5 TUBGCP6 TUBG1 TUBGCP3 | cytoskeleton organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MZT2B | TUBGCP2 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM boldt hein (TUBGCP2) Malo fraction boldt_WMM |
| TUBGCP2 | TUBGCP3 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (TUBGCP2) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| TUBGCP2 | TUBGCP6 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (TUBGCP2,TUBGCP6) Malo fraction |
| MZT2B | TUBGCP4 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM hein (TUBGCP4) boldt_WMM |
| MZT2B | TUBG1 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM hein (TUBG1) |
| MZT2B | TUBGCP5 | 1.0 | 0.949 | hein_WMM bioplex (MZT2B,TUBGCP5) bioplex_WMM hein (TUBGCP5) |
| TUBG1 | TUBGCP6 | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (TUBG1,TUBGCP6) Malo fraction |
| MZT2B | TUBGCP6 | 0.999 | 0.949 | hein_WMM bioplex (MZT2B) bioplex_WMM hein (TUBGCP6) |
| MZT2A | TUBGCP5 | 0.999 | 0.949 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (MZT2A,TUBGCP5) |
| TUBGCP6 | TUBGCP5 | 0.999 | 0.949 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (TUBGCP5,TUBGCP6) |
| TUBGCP5 | TUBGCP4 | 0.997 | 0.934 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (TUBGCP4,TUBGCP5) |
| TUBGCP5 | MZT1 | 0.994 | 0.919 | hein_WMM bioplex (MZT1,TUBGCP5) bioplex_WMM hein (MZT1,TUBGCP5) |
| TUBGCP5 | TUBGCP3 | 0.993 | 0.918 | hein_WMM bioplex (TUBGCP5) bioplex_WMM youn_WMM hein (TUBGCP5) |
| TUBGCP2 | TUBGCP5 | 0.991 | 0.909 | hein_WMM bioplex (TUBGCP5) bioplex_WMM hein (TUBGCP2,TUBGCP5) |
| TUBG1 | TUBGCP5 | 0.989 | 0.905 | hein_WMM bioplex (TUBGCP5) bioplex_WMM youn_WMM hein (TUBG1,TUBGCP5) |
| MZT2A | MZT1 | 0.985 | 0.899 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,MZT2A) |
| MZT2B | TUBGCP3 | 0.972 | 0.886 | hein_WMM bioplex (MZT2B) bioplex_WMM |
| TUBGCP3 | MZT1 | 0.965 | 0.875 | hein_WMM bioplex (MZT1,TUBGCP3) bioplex_WMM hein (MZT1) |
| TUBGCP6 | MZT1 | 0.924 | 0.843 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBGCP6) |
| TUBGCP2 | MZT1 | 0.908 | 0.831 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBGCP2) |
| MZT1 | TUBGCP4 | 0.867 | 0.801 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBGCP4) |
| MZT2B | MZT1 | 0.83 | 0.777 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1) |
| TUBG1 | TUBGCP4 | 0.824 | 0.773 | hein_WMM bioplex_WMM boldt youn_WMM hein (TUBG1,TUBGCP4) boldt_WMM |
| NME7 | TUBGCP5 | 0.759 | 0.749 | hein_WMM bioplex (TUBGCP5) bioplex_WMM youn_WMM hein (TUBGCP5) |
| MZT2A | TUBGCP3 | 0.734 | 0.738 | hein_WMM bioplex_WMM hein (MZT2A) gupta_WMM |
| TUBGCP2 | TUBGCP4 | 0.706 | 0.727 | hein_WMM bioplex_WMM boldt youn_WMM hein (TUBGCP2,TUBGCP4) boldt_WMM |
| TUBGCP2 | MZT2A | 0.657 | 0.696 | hein_WMM bioplex_WMM hein (MZT2A,TUBGCP2) gupta_WMM |
| NME7 | MZT1 | 0.643 | 0.687 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1) |
| NME7 | MZT2A | 0.624 | 0.678 | hein_WMM bioplex_WMM hein (MZT2A) gupta_WMM |
| TUBGCP6 | TUBGCP4 | 0.578 | 0.66 | hein_WMM bioplex_WMM hein (TUBGCP4,TUBGCP6) |
| NME7 | MZT2B | 0.575 | 0.657 | hein_WMM bioplex (MZT2B) bioplex_WMM |
| MZT2A | TUBGCP6 | 0.548 | 0.642 | hein_WMM bioplex_WMM hein (MZT2A,TUBGCP6) |
| TUBG1 | MZT1 | 0.548 | 0.642 | hein_WMM bioplex (MZT1) bioplex_WMM hein (MZT1,TUBG1) |
| TUBGCP2 | TUBG1 | 0.5 | 0.621 | hein_WMM bioplex_WMM boldt youn_WMM hein (TUBG1,TUBGCP2) gupta_WMM boldt_WMM |
| NME7 | TUBGCP2 | 0.468 | 0.605 | hein_WMM bioplex_WMM boldt (NME7) youn_WMM hein (TUBGCP2) gupta_WMM boldt_WMM |
| TUBGCP6 | TUBGCP3 | 0.422 | 0.573 | hein_WMM bioplex_WMM hein (TUBGCP6) |
| MZT2B | MZT2A | 0.374 | 0.546 | hein_WMM bioplex_WMM hein (MZT2A) |
| NME7 | TUBGCP6 | 0.369 | 0.544 | hein_WMM bioplex_WMM hein (TUBGCP6) |
| TUBGCP3 | TUBGCP4 | 0.343 | 0.531 | hein_WMM bioplex_WMM hein (TUBGCP4) boldt_WMM |
| MZT2A | TUBGCP4 | 0.275 | 0.487 | hein_WMM bioplex_WMM hein (MZT2A,TUBGCP4) |
| TUBG1 | TUBGCP3 | 0.25 | 0.473 | hein_WMM bioplex_WMM youn_WMM hein (TUBG1) gupta_WMM boldt_WMM |
| TUBG1 | MZT2A | 0.209 | 0.456 | hein_WMM bioplex_WMM hein (MZT2A,TUBG1) |
| NME7 | TUBGCP4 | 0.187 | 0.44 | hein_WMM bioplex_WMM boldt (NME7) youn_WMM hein (TUBGCP4) boldt_WMM |
| NME7 | TUBG1 | 0.135 | 0.406 | hein_WMM bioplex_WMM boldt (NME7) youn_WMM hein (TUBG1) gupta_WMM boldt_WMM |
| NME7 | TUBGCP3 | 0.017 | 0.175 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
Images
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Complex HuMAP2_06448 has an average edge precision of 0.744 which is ranked 1187 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MZT2B | HuMAP2_02682 HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| MZT2A | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP6 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP5 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| MZT1 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP4 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBG1 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP2 | HuMAP2_02682 HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| TUBGCP3 | HuMAP2_04088 HuMAP2_05416 HuMAP2_06448 |
| NME7 | HuMAP2_02020 HuMAP2_03882 HuMAP2_04975 HuMAP2_05416 HuMAP2_06448 |