hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06449
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AASDHPPT | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.7) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) (LYS5 ortholog) | UniProt NCBI |
| ITPA | Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (Putative oncogene protein hlc14-06-p) | UniProt NCBI |
| PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32) | UniProt NCBI |
| GCK | Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP534 | 0.0015833920549 | 0.5 | PCK1 GCK | Glycolysis and Gluconeogenesis |
| REAC:R-HSA-9615017 | 0.00253927088831 | 0.5 | PCK1 GCK | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| HP:0002919 | 0.0038810174634 | 0.5 | PCK1 GCK | Ketonuria |
| KEGG:00010 | 0.00389180767222 | 0.5 | PCK1 GCK | Glycolysis / Gluconeogenesis |
| KEGG:04922 | 0.00905997214328 | 0.5 | PCK1 GCK | Glucagon signaling pathway |
| KEGG:04910 | 0.0153578793248 | 0.5 | PCK1 GCK | Insulin signaling pathway |
| REAC:R-HSA-9614085 | 0.0165385846138 | 0.5 | PCK1 GCK | FOXO-mediated transcription |
| HP:0030188 | 0.0224167415402 | 0.5 | ITPA GCK | Tremor by anatomical site |
| REAC:R-HSA-70326 | 0.0331557329305 | 0.5 | PCK1 GCK | Glucose metabolism |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | AASDHPPT ITPA PCK1 GCK | Metabolism |
| KEGG:00524 | 0.0497141369515 | 0.25 | GCK | Neomycin, kanamycin and gentamicin biosynthesis |
| REAC:R-HSA-5619073 | 0.0499190562503 | 0.25 | GCK | Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITPA | AASDHPPT | 0.359 | 0.542 | bioplex_WMM youn_WMM gupta_WMM fraction |
| ITPA | GCK | 0.186 | 0.44 | fraction |
| ITPA | PCK1 | 0.053 | 0.299 | fraction |
| GCK | AASDHPPT | 0.007 | 0.005 | fraction |
Images
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Complex HuMAP2_06449 has an average edge precision of 0.322 which is ranked 4324 out of all 6965 complexes.
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